Dopamine D1 receptor agonist A-68930 ameliorates Aβ1-42-induced cognitive impairment and neuroinflammation in mice

2020 ◽  
Vol 88 ◽  
pp. 106963
Author(s):  
Zhao-Yan Cheng ◽  
Qing-Peng Xia ◽  
Yu-Hui Hu ◽  
Chen Wang ◽  
Ling He
Keyword(s):  
Cognitive Impairment ◽  
Receptor Agonist ◽  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
A 68930

A-68930, a novel potent dopamine D1 receptor agonist

1994 ◽  
Vol 5 (2) ◽  
pp. 210-218 ◽  
Author(s):  
H. A. Al-Naser ◽  
S. J. Cooper
Keyword(s):  
Receptor Agonist ◽  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
A 68930

A dopamine D1 receptor agonist improved learning and memory in morphine-treated rats

2018 ◽  
Vol 40 (12) ◽  
pp. 1080-1087 ◽  
Author(s):  
Qiaofeng Liu ◽  
Yanxia Li ◽  
Yang Liu ◽  
Yanshuang Zhao ◽  
Xuemei Li ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Receptor Agonist ◽  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Improved Learning

The dopamine D1 receptor agonist SKF 38393 improves temporal order memory performance in maternally deprived rats

2013 ◽  
Vol 106 ◽  
pp. 268-273 ◽  
Author(s):  
Stéphanie Lejeune ◽  
Nathalie Dourmap ◽  
Marie-Pascale Martres ◽  
Bruno Giros ◽  
Valérie Daugé ◽  
...  
Keyword(s):  
Receptor Agonist ◽  
Temporal Order ◽  
Memory Performance ◽  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Skf 38393 ◽  
Temporal Order Memory

D1 and D2 dopaminergic systems in the rat basolateral amygdala are involved in anxiogenic-like effects induced by histamine

2011 ◽  
Vol 26 (4) ◽  
pp. 564-574 ◽  
Author(s):  
Maryam Bananej ◽  
Ahmad Karimi-Sori ◽  
Mohammad Reza Zarrindast ◽  
Shamseddin Ahmadi
Keyword(s):  
Receptor Antagonist ◽  
Receptor Agonist ◽  
Basolateral Amygdala ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Dopamine D2 ◽  
D1 And D2 Receptors ◽  
Male Wistar Rats

Involvement of the dopamine receptors in the basolateral amygdala (BLA) in the effects of histamine on anxiety-like behaviors of the elevated plus maze in male Wistar rats was investigated. The results showed that bilateral intra-BLA injections of histamine (2.5, 5 and 7.5 µg/rat) induced an anxiogenic-like effect, revealed by decreases in percentage of open arm time (%OAT) and open arm entries (%OAE). Intra-BLA administration of dopamine D1 receptor agonist, SKF38393 (0.25 µg/rat), and dopamine D2 receptor agonist, quinpirole (0.03 and 0.05 µg/rat), decreased %OAT but not %OAE. Conversely, intra-BLA administration of dopamine D1 receptor antagonist, SCH23390 (0.5 and 1 µg/rat), and dopamine D2 receptor antagonist, sulpiride (0.3 and 0.5 µg/rat), increased %OAT and %OAE, suggesting an anxiolytic-like effect for both drugs. Interestingly, co-administration of a silent dose of SCH23390 or sulpiride prevented anxiogenic-like effects of SKF38393 and quinpirole, respectively. Conjoint administration of a sub-effective dose of SKF38393 (0.125 µg/rat) or quinpirole (0.01 µg/rat) along with lower doses of histamine (1 and 2.5 µg/rat) induced anxiolytic-like effects. On the other hand, intra-BLA pretreatment with a silent dose of SCH23390 (0.25 µg/rat) or sulpiride (0.1 µg/rat) prevented the anxiogenic-like effect of higher doses of histamine (5 and 7.5 µg/rat). No significant change was observed in total closed arm entries, as an index for motor activity of the animals. It can be concluded that the dopamine D1 and D2 receptors in the BLA may be involved in the anxiogenic-like effects induced by histamine.

A-86929: A selective dopamine D1 receptor agonist with anti-Parkinsonian efficacy in MPTP-lesioned primate models

1995 ◽  
Vol 31 ◽  
pp. 108
Author(s):  
K. Shiosaki ◽  
P. Jenner ◽  
P. Bedard ◽  
C.W. Lin ◽  
D. Britton ◽  
...  
Keyword(s):  
Receptor Agonist ◽  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Selective Dopamine

Renal effect of YM435, a new dopamine D1 receptor agonist, in anesthetized dogs

1997 ◽  
Vol 322 (1) ◽  
pp. 45-53 ◽  
Author(s):  
Takeyuki Yatsu ◽  
Yukinori Arai ◽  
Kenji Takizawa ◽  
Chieko Kasai-Nakagawa ◽  
Masahiro Takanashi ◽  
...  
Keyword(s):  
Receptor Agonist ◽  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Renal Effect ◽  
Anesthetized Dogs
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