Activation of dendritic cells by low molecular weight oyster polysaccharides

2017 ◽  
Vol 44 ◽  
pp. 183-190 ◽  
Author(s):  
Ming Zhong ◽  
Cheng Zhong ◽  
Tingting Wang ◽  
Pei Hu ◽  
Guanghui Wang ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Dendritic Cells ◽  
Low Molecular Weight

Low molecular weight hyaluronan preconditioning of tumor-pulsed dendritic cells increases their migratory ability and induces immunity against murine colorectal carcinoma

2011 ◽  
Vol 60 (10) ◽  
pp. 1383-1395 ◽  
Author(s):  
Laura Alaniz ◽  
Manglio Rizzo ◽  
Mariana G. Garcia ◽  
Flavia Piccioni ◽  
Jorge B. Aquino ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Dendritic Cells ◽  
Colorectal Carcinoma ◽  
Low Molecular Weight

A Novel Low Molecular Weight Inhibitor of Dendritic Cells and B Cells Blocks Allergic Inflammation

2006 ◽  
Vol 173 (6) ◽  
pp. 599-606 ◽  
Author(s):  
Peter Ettmayer ◽  
Peter Mayer ◽  
Frank Kalthoff ◽  
Wolfgang Neruda ◽  
Nathalie Harrer ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Dendritic Cells ◽  
B Cells ◽  
Allergic Inflammation ◽  
Low Molecular Weight

scholarly journals SARS-CoV-2 Infection and Transmission Depends on Heparan Sulfates and Is Blocked by Low Molecular Weight Heparins

2020 ◽  
Author(s):  
Marta Bermejo-Jambrina ◽  
Julia Eder ◽  
Tanja M. Kaptein ◽  
Leanne C. Helgers ◽  
Philip J.M. Brouwer ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Dendritic Cells ◽  
Epithelial Cells ◽  
Heparan Sulfate ◽  
Alveolar Macrophages ◽  
Neutralizing Antibodies ◽  
Heparan Sulfate Proteoglycans ◽  
Low Molecular Weight ◽  
Low Molecular Weight Heparins ◽  
Heparan Sulfates

AbstractThe current pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and new outbreaks worldwide highlight the need for preventive treatments. Although angiotensin converting enzyme 2 (ACE2) is the primary receptor for SARS-CoV-2, we identified heparan sulfate proteoglycans expressed by epithelial cells, alveolar macrophages and dendritic cells as co-receptors for SARS-CoV-2. Low molecular weight heparins (LMWH) blocked SARS-CoV-2 infection of epithelial cells and alveolar macrophages, and virus dissemination by dendritic cells. Notably, potent neutralizing antibodies from COVID-19 patients interfered with SARS-CoV-2 binding to heparan sulfate proteoglycans, underscoring the importance of heparan sulfate proteoglycans as receptors and uncover that SARS-CoV-2 binding to heparan sulfates is an important mechanism for neutralization. These results have imperative implications for our understanding of SARS-CoV-2 host cell entry and reveal an important target for novel prophylactic intervention.

LOW MOLECULAR WEIGHT OLIGOSACCHARIDES OF HYALURONAN POTENTLY ACTIVATE DENDRITIC CELLS

Hyaluronan ◽  
2002 ◽  
pp. 457-468
Author(s):  
Christian C. Termeer ◽  
Peter Prehm ◽  
Jan C. Simon
Keyword(s):  
Molecular Weight ◽  
Dendritic Cells ◽  
Low Molecular Weight

scholarly journals Low Molecular Weight Hyaluronan-Pulsed Human Dendritic Cells Showed Increased Migration Capacity and Induced Resistance to Tumor Chemoattraction

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e107944 ◽  
Author(s):  
Manglio Rizzo ◽  
Juan Bayo ◽  
Flavia Piccioni ◽  
Mariana Malvicini ◽  
Esteban Fiore ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Dendritic Cells ◽  
Induced Resistance ◽  
Low Molecular Weight ◽  
Migration Capacity ◽  
Human Dendritic Cells

Hydrophobic chain modified low molecular weight polyethylenimine for efficient antigen delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (17) ◽  
pp. 13636-13643 ◽  
Author(s):  
Hui Wang ◽  
Jian Chen ◽  
Jiajun Ying ◽  
Yuhong Xu ◽  
Ruilong Sheng
Keyword(s):  
Molecular Weight ◽  
Dendritic Cells ◽  
Tumor Cells ◽  
Low Molecular Weight ◽  
Antigen Delivery ◽  
Therapeutic Vaccines ◽  
Cross Presentation ◽  
Cell Responses ◽  
Hydrophobic Chain ◽  
Antigen Presenting

Developing new therapeutic vaccines to promote antigen cross-presentation in antigen-presenting cells, especially dendritic cells, is regarded as a promising approach to prime antigen-specific T cell responses against tumor cells.

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