Berberine alleviates postoperative cognitive dysfunction by suppressing neuroinflammation in aged mice

2016 ◽  
Vol 38 ◽  
pp. 426-433 ◽  
Author(s):  
Zhijie Zhang ◽  
Xiuhua Li ◽  
Fayin Li ◽  
Lijun An
Keyword(s):  
Cognitive Dysfunction ◽  
Postoperative Cognitive Dysfunction ◽  
Aged Mice

scholarly journals High-Pressure Pneumoperitoneum Aggravates Surgery-Induced Neuroinflammation and Cognitive Dysfunction in Aged Mice

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Bo Lu ◽  
Hui Yuan ◽  
Xiaojie Zhai ◽  
Xiaoyu Li ◽  
Jinling Qin ◽  
...  
Keyword(s):  
High Pressure ◽  
Cognitive Dysfunction ◽  
Microglial Activation ◽  
Postoperative Cognitive Dysfunction ◽  
Abdominal Pressure ◽  
Common Complication ◽  
Operative Field ◽  
Aged Patients ◽  
Aged Mice ◽  
Postoperative Cognitive Impairment

Postoperative cognitive dysfunction (POCD) is a common complication after surgery, especially in aged patients. Neuroinflammation has been closely associated with the development of POCD. While the contribution of pneumoperitoneum to the systemic inflammation has been well documented, the effect of pneumoperitoneal pressure on neuroinflammation and postoperative cognitive function remains unclear. In this study, we showed that high-pressure pneumoperitoneum promoted the postoperative neuroinflammation and microglial activation in the hippocampus and aggravated the postoperative cognitive impairment in aged mice. These results support the requirement to implement interventions with lower intra-abdominal pressure, which allows for adequate exposure of the operative field rather than a routine pressure.

scholarly journals Protective Effect of RNase on Unilateral Nephrectomy-Induced Postoperative Cognitive Dysfunction in Aged Mice

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0134307 ◽  
Author(s):  
Chan Chen ◽  
Jingjing Cai ◽  
Shu Zhang ◽  
Lu Gan ◽  
Yuanlin Dong ◽  
...  
Keyword(s):  
Protective Effect ◽  
Cognitive Dysfunction ◽  
Postoperative Cognitive Dysfunction ◽  
Unilateral Nephrectomy ◽  
Aged Mice

scholarly journals High-fat diet aggravates postoperative cognitive dysfunction in aged mice

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Lan Wei ◽  
Minmin Yao ◽  
Zhimeng Zhao ◽  
Hui Jiang ◽  
Shengjin Ge
Keyword(s):  
Cognitive Dysfunction ◽  
High Fat Diet ◽  
Postoperative Cognitive Dysfunction ◽  
High Fat ◽  
Aged Mice

Dexmedetomidine Ameliorates Postoperative Cognitive Dysfunction in Aged Mice

2021 ◽  
Author(s):  
Xiaolan Xie ◽  
Zhiwen Shen ◽  
Chuwen Hu ◽  
Kun Zhang ◽  
Mingyan Guo ◽  
...  
Keyword(s):  
Cognitive Dysfunction ◽  
Postoperative Cognitive Dysfunction ◽  
Aged Mice

scholarly journals Microarray Analysis Identifies Key Differentially Expressed Circular RNAs in Aged Mice With Postoperative Cognitive Dysfunction

2021 ◽  
Vol 13 ◽  
Author(s):  
Yu-Qing Wu ◽  
Qiang Liu ◽  
Hai-Bi Wang ◽  
Chen Chen ◽  
Hui Huang ◽  
...  
Keyword(s):  
Cognitive Dysfunction ◽  
Protein Interactions ◽  
Expression Profiles ◽  
Postoperative Cognitive Dysfunction ◽  
Enrichment Analysis ◽  
Differentially Expressed ◽  
Circular Rnas ◽  
Protein Protein Interactions ◽  
Hub Genes ◽  
Aged Mice

Postoperative cognitive dysfunction (POCD) is a common complication in elderly patients. Circular RNAs (circRNAs) may contribute to neurodegenerative diseases. However, the role of circRNAs in POCD in aged mice has not yet been reported. This study aimed to explore the potential circRNAs in a POCD model. First, a circRNA microarray was used to analyze the expression profiles. Differentially expressed circRNAs were validated using quantitative real-time polymerase chain reaction. A bioinformatics analysis was then used to construct a competing endogenous RNA (ceRNA) network. The database for annotation, visualization, and integrated discovery was used to perform Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis of circRNA-related genes. Moreover, protein-protein interactions were analyzed to predict the circRNA-regulated hub genes using the STRING and molecular complex detection plug-in of Cytoscape. Microarray screen 124 predicted circRNAs in the POCD of aged mice. We found that the up/downregulated circRNAs were involved in multiple signaling pathways. Hub genes, including Egfr and Prkacb, were identified and may be regulated by ceRNA networks. These results suggest that circRNAs are dysexpressed in the hippocampus and may contribute to POCD in aged mice.

The Expression of Interleukin-1β is Regulated by DNA Methylation in Microglia to Mediate Postoperative Cognitive Dysfunction in Aged Mice

2021 ◽  
Author(s):  
Yin Gao ◽  
Li Yang ◽  
Xiu Yang ◽  
Jing-Ru Hao ◽  
Xiao-Ran Shen ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Cognitive Dysfunction ◽  
Dna Methyltransferase ◽  
Dorsal Hippocampus ◽  
Postoperative Cognitive Dysfunction ◽  
Exploratory Laparotomy ◽  
Interleukin 1Β ◽  
Aged Mice ◽  
Specific Pcr ◽  
Adult Mice

Abstract Postoperative cognitive dysfunction (POCD) is a common postoperative complication in elderly individuals. Neuroinflammation is closely related to its occurrence. However, the exact molecular mechanism underlying this link is undetermined. This study aimed to establish a mouse model of POCD to explore the role of DNA methylation in regulating the expression of interleukin-1β (IL-1β), which mediates the occurrence of POCD in aged mice. The POCD model was established by exploratory laparotomy and evaluated by novel object and Y-maze tests. We also assessed IL-1β production in the dorsal hippocampus and the expression of the DNA methylation-related proteins DNA methyltransferase 3a (DNMT3a), DNA methyltransferase 3b (DNMT3b), and methyl CpG binding protein 2 (MeCP2). Methylation specific PCR (MSP), methylated DNA immunoprecipitation (MeDIP) and DNA methylation sequencing in IL-1β promoter were used to explore the regulation of IL-1β by DNA methylation in this model. Finally, Golgi-Cox staining and Western blotting were used to further explore the role and potential mechanisms of IL-1β in POCD. Cognitive impairment was observed in aged but not adult mice. In aged mice, the microglia cells in the dorsal hippocampus were activated, while the DNA methylation in the IL-1β promoter was decreased. Interestingly, the global DNA methylation in the dorsal hippocampus was unchanged. IL-1β inhibition prevented surgery-induced cognitive decline and dysfunction of synaptic plasticity. Overall, these results indicated that DNA methylation regulation of IL-1β expression may be an important mechanism increasing the susceptibility to POCD.

Dexmedetomidine improves early postoperative cognitive dysfunction in aged mice

2015 ◽  
Vol 746 ◽  
pp. 206-212 ◽  
Author(s):  
Xiao-Lan Qian ◽  
Wei Zhang ◽  
Ming-Zheng Liu ◽  
Yu-Bing Zhou ◽  
Jing-Min Zhang ◽  
...  
Keyword(s):  
Cognitive Dysfunction ◽  
Postoperative Cognitive Dysfunction ◽  
Aged Mice

scholarly journals Intervention of NF-Κb Signaling Pathway and Preventing Post-Operative Cognitive Dysfunction as Well as Neuronal Apoptosis

2022 ◽  
Author(s):  
Na Yuan ◽  
Xiuzhen Wang ◽  
Yu Zhang ◽  
Lingsi Kong ◽  
Liyong Yuan ◽  
...  
Keyword(s):  
Cognitive Dysfunction ◽  
Neuronal Apoptosis ◽  
Inflammatory Responses ◽  
Postoperative Cognitive Dysfunction ◽  
Saline Control ◽  
Control Group ◽  
Sham Operation ◽  
Secondary Brain Injury ◽  
Aged Mice ◽  
Operation Group

Background: The Postoperative cognitive dysfunction (POCD) model was constructed by resection of the left hepatic lobe in aged mice to determine the behavioral effects of the POCD model in aged mice and the relationship between NF-κB and POCD in apoptosis and autophagy. Provide a theoretical basis for POCD prevention and treatment. Methods: This study was carried out in Ningbo No. 6 Hospital, Zhejiang, China, from Jun 2019 to Dec 2020. The POCD model was constructed after resection of the left extrahepatic lobe in aged mice and randomly divided into 6 groups: sham operation group, operation group (normal saline control group, solvent group, YC-1 group, PDTC group and 3-MA group). Related indicators of behavioral changes, neuronal inflammatory responses, apoptosis, and autophagy were examined. Results: The escape latency of the aged mice in the surgical group was significantly prolonged at three time points compared with the control group, and the number of insertions decreased significantly. Microglia are activated and the inflammatory response is increased, whereas PDTC has an inhibitory effect. It was demonstrated that apoptosis and necrosis of neurons can be induced by the NF-κb pathway, and autophagy can be promoted, whereas autophagy occurs before apoptosis. Conclusion: Activation of NF-κb pathway in neurons after POCD causes neuronal apoptosis and autophagy, and cognitive impairment occurs. PDTC, a NF-κb pathway inhibitor, can effectively reduce neuronal apoptosis induced by secondary brain injury after POCD. Necrosis, to protect the brain tissue.  

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