The activation of M2 muscarinic receptor inhibits cell growth and survival in human glioblastoma cancer stem cells

2015 ◽  
Vol 29 (1) ◽  
pp. 105-109 ◽  
Author(s):  
Francesco Alessandrini ◽  
Ilaria Cristofaro ◽  
Maria Di Bari ◽  
Jacopo Zasso ◽  
Luciano Conti ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cell Growth ◽  
Cancer Stem Cells ◽  
Muscarinic Receptor ◽  
Human Glioblastoma ◽  
Growth And Survival ◽  
M2 Muscarinic Receptor ◽  
Cell Growth And Survival

Non-overlapping Promoter and Super-enhancer Driven Processes Support Myeloma Cell Growth and Survival via Distinct Regulatory Axes

2017 ◽  
Vol 17 (1) ◽  
pp. e1
Author(s):  
Mariateresa Fulciniti ◽  
Charles Lin ◽  
Mehmet Samur ◽  
Rick Young ◽  
Kenneth C. Anderson ◽  
...  
Keyword(s):  
Cell Growth ◽  
Myeloma Cell ◽  
Growth And Survival ◽  
Super Enhancer ◽  
Cell Growth And Survival

scholarly journals HNRNPH1 is required for rhabdomyosarcoma cell growth and survival

Oncogenesis ◽  
2018 ◽  
Vol 7 (1) ◽  
Author(s):  
Yanfeng Li ◽  
Jesse Bakke ◽  
David Finkelstein ◽  
Hu Zeng ◽  
Jing Wu ◽  
...  
Keyword(s):  
Cell Growth ◽  
Growth And Survival ◽  
Rhabdomyosarcoma Cell ◽  
Cell Growth And Survival

scholarly journals Functional involvement of Daxx in gp130-mediated cell growth and survival in BaF3 cells

2010 ◽  
Vol 40 (12) ◽  
pp. 3570-3580 ◽  
Author(s):  
Ryuta Muromoto ◽  
Makoto Kuroda ◽  
Sumihito Togi ◽  
Yuichi Sekine ◽  
Asuka Nanbo ◽  
...  
Keyword(s):  
Cell Growth ◽  
Growth And Survival ◽  
Functional Involvement ◽  
Cell Growth And Survival

scholarly journals KDM6B modulates MAPK pathway mediating multiple myeloma cell growth and survival

Leukemia ◽  
2017 ◽  
Vol 31 (12) ◽  
pp. 2661-2669 ◽  
Author(s):  
H Ohguchi ◽  
T Harada ◽  
M Sagawa ◽  
S Kikuchi ◽  
Y-T Tai ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Cell Growth ◽  
Mapk Pathway ◽  
Myeloma Cell ◽  
Growth And Survival ◽  
Multiple Myeloma Cell ◽  
Cell Growth And Survival

scholarly journals Docosahexaenoic Acid has stem cell-specific effects in the SVZ and restores olfactory neurogenesis and function in the aging brain

2020 ◽  
Author(s):  
JE Le Belle ◽  
J Sperry ◽  
K Ludwig ◽  
NG Harris ◽  
MA Caldwell ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Stem Cells ◽  
Stem Cell ◽  
Cell Growth ◽  
Olfactory Bulb ◽  
Neural Stem Cells ◽  
Egf Receptor ◽  
Brain Repair ◽  
Multipotent Stem Cells ◽  
Growth And Survival

AbstractFatty acids are well known as important constituents for the synthesis of membrane lipids and as sources of cellular energy in the CNS. However, fatty acids can also act as vital second messenger molecules in the nervous system and regulate the activity of many proteins affecting cell growth and survival. Here, we show that an essential dietary fatty acid, Decosahexaenoic acid, (DHA), can enhance stem cell function in vitro and in vivo. We found that this effect is not due to an increase in the overall proliferation rate of all neural progenitors, but is due to an increase in the number of multipotent stem cells that leads to greater levels of subventricular zone (SVZ) neurogenesis with restoration of olfactory function in aged mice. These effects were likely mediated through increased EGF-receptor sensitivity, a conversion of EGRFR+ progenitors back into an EGRFR+/GFAP+ stem cell state, and the activation of the PI3K/AKT signaling pathway, which is a critical pathway in many NSC cell functions including cell growth and survival. Together these data demonstrate that neural stem cells in the aged and quiescent neurogenic niche of the mouse SVZ retain their ability to self-renew and contribute to neurogenesis when apparently rejuvenated by DHA and PI3K/AKT pathway activation. DHA stimulation of this signaling enhances the number of multipotent stem cells and neurogenesis in young and aged rodent and human stem cells and hence may have implications for the manipulation of neural stem cells for brain repair.Significance StatementWe have identified potentially important effects of DHA on the stem cell population which may be unique to the SVZ stem cell niche. Our studies demonstrate that DHA can promote the production of neural stem cells, possibly via a non-proliferative mechanism stimulated by EGF receptor activation, and prolongs their viability. Aging animals undergo an apparent loss in SVZ stem cells and an associated decline in olfactory bulb function. We find that dietary DHA supplementation at least partially restores stem cell numbers, olfactory bulb neurogenesis and olfactory discrimination and memory in aged mice, demonstrating a capacity for rejuvenation is retained despite age-related changes to the niche, which has significant implications for ameliorating cognitive decline in aging and for endogenous brain repair.

scholarly journals p38-mediated cell growth and survival drive rapid embryonic wound repair

Cell Reports ◽  
2021 ◽  
Vol 37 (3) ◽  
pp. 109874
Author(s):  
Gordana Scepanovic ◽  
Miranda Victoria Hunter ◽  
Ran Kafri ◽  
Rodrigo Fernandez-Gonzalez
Keyword(s):  
Cell Growth ◽  
Wound Repair ◽  
Growth And Survival ◽  
Cell Growth And Survival
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