scholarly journals Neutrophil cell surface receptors and their intracellular signal transduction pathways

2013 ◽  
Vol 17 (3) ◽  
pp. 638-650 ◽  
Author(s):  
Krisztina Futosi ◽  
Szabina Fodor ◽  
Attila Mócsai
Keyword(s):  
Signal Transduction ◽  
Cell Surface ◽  
Signal Transduction Pathways ◽  
Cell Surface Receptors ◽  
Intracellular Signal Transduction ◽  
Surface Receptors ◽  
Intracellular Signal ◽  
Neutrophil Cell

Efficient, Retro Viral-Mediated Expression Of GFP Fusion Proteins as Inhibitors of Intracellular Signal Transduction Pathways: A Case Study

1998 ◽  
Vol 4 (S2) ◽  
pp. 1012-1013
Author(s):  
T.J. Murphy ◽  
Xiaofei Wang
Keyword(s):  
Gene Expression ◽  
Signal Transduction ◽  
Cell Surface ◽  
Model Systems ◽  
Signal Transduction Pathways ◽  
Cell Surface Receptors ◽  
Intracellular Signal Transduction ◽  
Surface Receptors ◽  
Extracellular Stimuli ◽  
Intracellular Signal

A variety of extracellular signals, including hormones, neurotransmitters, growth factors and cytokines, are capable of activating vascular smooth muscle cells (VSMC). These can modulate the VSMC phenotype, which underlies the progression of vascular diseases. We study gene expression control responses in VSMC that are regulated by different classes of cell surface receptors. Taken as simpler model systems for the pleiotropic sensitivity of VSMC to extracellular stimuli, we focus on understanding the elements of intracellular signal transduction pathways involved in controlling gene expression. In particular, we are interested in identifying signaling elements that can be activated by multiple classes of cell surface receptors.Previous studies had supported both a role of protein kinase A (PKA) activity and transcriptional induction of an unknown factor in control of ATI angiotensin receptor gene expression in VSMC (1). The mRNA from this gene is down-regulated by a variety of extracellular stimuli, and we hypothesized that stimulation of PKA by several classes of receptors might explain the apparently pleiotropic nature of ATI-receptor down regulation.

scholarly journals Phosphorylation of Cell Surface Receptors: A Mechanism for Regulating Signal Transduction Pathways

1988 ◽  
Vol 9 (1) ◽  
pp. 38-56 ◽  
Author(s):  
DAVID R. SIBLEY ◽  
JEFFREY L. BENOVIC ◽  
MARC G. CARON ◽  
ROBERT J. LEFKOWITZ
Keyword(s):  
Signal Transduction ◽  
Cell Surface ◽  
Signal Transduction Pathways ◽  
Cell Surface Receptors ◽  
Surface Receptors

Intracellular signalling

2010 ◽  
pp. 169-176
Author(s):  
R. Andres Floto
Keyword(s):  
Signal Transduction ◽  
Plasma Membrane ◽  
Cell Surface ◽  
Intracellular Signalling ◽  
Cell Surface Receptors ◽  
Surface Receptors ◽  
Transmission Of Information ◽  
Effective Transmission

This section outlines the general principles of intracellular signalling. Focusing on cell surface receptors, the requirements for effective transmission of information across the plasma membrane are outlined. The principal mechanisms utilized in mammalian signal transduction are described. For each, the pathological consequences of aberrant signalling and means by which pathways can be pharmacologically targeted are described in molecular terms....

Intracellular signal transduction pathways in sponges

1990 ◽  
Vol 3 (1) ◽  
pp. 97-114 ◽  
Author(s):  
Werner E.G. Müller ◽  
Durdica Ugarković ◽  
Vera Gamulin ◽  
Barbara E. Weiler ◽  
Heinz C. Schröder
Keyword(s):  
Signal Transduction ◽  
Signal Transduction Pathways ◽  
Intracellular Signal Transduction ◽  
Intracellular Signal

scholarly journals Visual Cortex Plasticity: A Complex Interplay of Genetic and Environmental Influences

2012 ◽  
Vol 2012 ◽  
pp. 1-14 ◽  
Author(s):  
José Fernando Maya-Vetencourt ◽  
Nicola Origlia
Keyword(s):  
Gene Expression ◽  
Signal Transduction ◽  
Nervous System ◽  
Sensory Deprivation ◽  
Environmental Influences ◽  
Signal Transduction Pathways ◽  
Gene Promoters ◽  
Complex Interplay ◽  
Intracellular Signal Transduction ◽  
Intracellular Signal

The central nervous system architecture is highly dynamic and continuously modified by sensory experience through processes of neuronal plasticity. Plasticity is achieved by a complex interplay of environmental influences and physiological mechanisms that ultimately activate intracellular signal transduction pathways regulating gene expression. In addition to the remarkable variety of transcription factors and their combinatorial interaction at specific gene promoters, epigenetic mechanisms that regulate transcription have emerged as conserved processes by which the nervous system accomplishes the induction of plasticity. Experience-dependent changes of DNA methylation patterns and histone posttranslational modifications are, in fact, recruited as targets of plasticity-associated signal transduction mechanisms. Here, we shall concentrate on structural and functional consequences of early sensory deprivation in the visual system and discuss how intracellular signal transduction pathways associated with experience regulate changes of chromatin structure and gene expression patterns that underlie these plastic phenomena. Recent experimental evidence for mechanisms of cross-modal plasticity following congenital or acquired sensory deprivation both in human and animal models will be considered as well. We shall also review different experimental strategies that can be used to achieve the recovery of sensory functions after long-term deprivation in humans.

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