Schizandrin C exerts anti-neuroinflammatory effects by upregulating phase II detoxifying/antioxidant enzymes in microglia

2013 ◽  
Vol 17 (2) ◽  
pp. 415-426 ◽  
Author(s):  
Sun Young Park ◽  
Se Jin Park ◽  
Tae Gyeong Park ◽  
Seetharaman Rajasekar ◽  
Sang-Joon Lee ◽  
...  
Keyword(s):  
Antioxidant Enzymes ◽  
Phase Ii

scholarly journals 4-Hydroxyphenylacetic Acid Prevents Acute APAP-Induced Liver Injury by Increasing Phase II and Antioxidant Enzymes in Mice

2018 ◽  
Vol 9 ◽  
Author(s):  
Hongqiong Zhao ◽  
Zhihui Jiang ◽  
Xuemei Chang ◽  
Huiting Xue ◽  
Wumaierjiang Yahefu ◽  
...  
Keyword(s):  
Antioxidant Enzymes ◽  
Liver Injury ◽  
Phase Ii ◽  
Hydroxyphenylacetic Acid

Increase of the Activity of Phase II Antioxidant Enzymes in Rats after a Single Dose of Coffee

2011 ◽  
Vol 59 (20) ◽  
pp. 10887-10892 ◽  
Author(s):  
Silvio José Valadão Vicente ◽  
Emília Yasuko Ishimoto ◽  
Robison José Cruz ◽  
Camilo Dias Seabra Pereira ◽  
Elizabeth Aparecida Ferraz Da Silva Torres
Keyword(s):  
Antioxidant Enzymes ◽  
Single Dose ◽  
Phase Ii

scholarly journals Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway

2009 ◽  
Vol 130 (3) ◽  
pp. 244-251 ◽  
Author(s):  
Marc A. Riedl ◽  
Andrew Saxon ◽  
David Diaz-Sanchez
Keyword(s):  
Antioxidant Enzymes ◽  
Phase Ii ◽  
Upper Airway

scholarly journals Modulatory effects of rutin on the expression of cytochrome P450s and antioxidant enzymes in human hepatoma cells

2016 ◽  
Vol 66 (4) ◽  
pp. 491-502 ◽  
Author(s):  
Sedar Karakurt
Keyword(s):  
Antioxidant Enzymes ◽  
Phase Ii ◽  
Hepg2 Cells ◽  
Cytochrome P450s ◽  
Dependent Manner ◽  
Protective Effects ◽  
Human Hepatoma Cells ◽  
Metabolizing Enzymes ◽  
Protein Expressions ◽  
Dose Dependent

Abstract Expression of a drug and xenobiotic metabolizing enzymes, cytochrome P450s (CYPs), and antioxidant enzymes can be modulated by various factors. The flavonoid rutin was investigated for its anti-carcinogen and protective effects as well as modulatory action on CYPs and phase II enzymes in human hepatocellular carcinoma cells. Rutin inhibited proliferation of HEPG2 cells in a dose-dependent manner with the IC50 value of 52.7 μmol L-1 and invasion of HEPG2 cells (21.6 %, p = 0.0018) and colony formation of those invaded cells (57.4 %, p < 0.0001). Rutin treatment also significantly increased early/late-stage apoptosis in HEPG2 cells (28.9 %, p < 0.001). Treatment by rutin significantly inhibited protein expressions of cytochrome P450-dependent CYP3A4 (75.3 %, p < 0.0001), elevated CYP1A1 enzymes (1.7-fold, p = 0.0084) and increased protein expressions of antioxidant and phase II reaction catalyzing enzymes, NQO1 (2.42-fold, p < 0.0001) and GSTP1 (2.03-fold, p < 0.0001). Besides, rutin treatment significantly inhibited mRNA expression of CYP3A4 (73.2 %, p=0.0014). Also, CYP1A1, NQO1 and GSTP1 mRNA expressions were significantly increased 2.77-fold (p = 0.029), 4.85- fold (p = 0.0051) and 9.84-fold (p < 0.0001), respectively.

scholarly journals Roots ofWithania somniferaInhibit Forestomach and Skin Carcinogenesis in Mice

2005 ◽  
Vol 2 (1) ◽  
pp. 99-105 ◽  
Author(s):  
Bandhuvula Padmavathi ◽  
Pramod C. Rath ◽  
Araga Ramesha Rao ◽  
Rana Pratap Singh
Keyword(s):  
Antioxidant Enzymes ◽  
Phase I ◽  
Phase Ii ◽  
Antitumor Agents ◽  
Body Weight Gain ◽  
Skin Carcinogenesis ◽  
The Body ◽  
Tumor Incidence ◽  
Swiss Albino Mouse ◽  
Anticancer Effects

We evaluated the cancer chemopreventive efficacy of theWithania somniferaroot, which has been used in the Indian traditional medicine system for many centuries for the treatment of various ailments. Since, studies showing its mechanism-based cancer chemopreventive efficacy are limited, this was investigated in the present study. We studied the effect of dietary administration ofWithaniaroot on hepatic phase I, phase II and antioxidant enzymes by estimation of its level/activity, as well as in attenuating carcinogen-induced forestomach and skin tumorigenesis in the Swiss albino mouse model. Our findings showed that roots ofW.somniferainhibit phase I, and activates phase II and antioxidant enzymes in the liver. Further, in a long-term tumorigenesis study,Withaniainhibited benzo(a)pyrene-induced forestomach papillomagenesis, showing up to 60 and 92% inhibition in tumor incidence and multiplicity, respectively. Similarly,Withaniainhibited 7,12-dimethylbenzanthracene-induced skin papillomagenesis, showing up to 45 and 71% inhibition in tumor incidence and multiplicity. In both studies,Withaniashowed no apparent toxic effects in mice as monitored by the body weight gain profile. Together, these findings suggest thatW.somniferaroot has chemopreventive efficacy against forestomach and skin carcinogenesis and warrants the identification and isolation of active compounds responsible for its anticancer effects, which may provide the lead for the development of antitumor agents.

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