Astragalus polysaccharides enhance immune responses of HBV DNA vaccination via promoting the dendritic cell maturation and suppressing Treg frequency in mice

2012 ◽  
Vol 14 (4) ◽  
pp. 463-470 ◽  
Author(s):  
Xiaogang Du ◽  
Bing Zhao ◽  
Jinyao Li ◽  
Xiaohan Cao ◽  
Mingkun Diao ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Immune Responses ◽  
Dna Vaccination ◽  
Dendritic Cell Maturation ◽  
Hbv Dna ◽  
Cell Maturation ◽  
Astragalus Polysaccharides ◽  
Treg Frequency

Induction of dendritic cell maturation and modulation of dendritic cell-induced immune responses by prostaglandins

2000 ◽  
Vol 292 (9) ◽  
pp. 437-445 ◽  
Author(s):  
K. Steinbrink ◽  
L. Paragnik ◽  
H. Jonuleit ◽  
T. Tüting ◽  
J. Knop ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Immune Responses ◽  
Dendritic Cell Maturation ◽  
Cell Maturation

scholarly journals [Gd@C82(OH)22]n Nanoparticles Induce Dendritic Cell Maturation and Activate Th1 Immune Responses

ACS Nano ◽  
2010 ◽  
Vol 4 (2) ◽  
pp. 1178-1186 ◽  
Author(s):  
De Yang ◽  
Yuliang Zhao ◽  
Hua Guo ◽  
Yana Li ◽  
Poonam Tewary ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Immune Responses ◽  
Dendritic Cell Maturation ◽  
Cell Maturation ◽  
Th1 Immune Responses

scholarly journals Enhanced Dendritic Cell Maturation by TNF-α or Cytidine-Phosphate-Guanosine DNA Drives T Cell Activation In Vitro and Therapeutic Anti-Tumor Immune Responses In Vivo

2000 ◽  
Vol 165 (11) ◽  
pp. 6278-6286 ◽  
Author(s):  
Christoph Brunner ◽  
Julia Seiderer ◽  
Angelika Schlamp ◽  
Martin Bidlingmaier ◽  
Andreas Eigler ◽  
...  
Keyword(s):  
T Cell ◽  
Dendritic Cell ◽  
Immune Responses ◽  
T Cell Activation ◽  
Cell Activation ◽  
Dendritic Cell Maturation ◽  
Cell Maturation ◽  
Tnf Α

scholarly journals Ascophyllan Purified from Ascophyllum nodosum Induces Th1 and Tc1 Immune Responses by Promoting Dendritic Cell Maturation

Marine Drugs ◽  
2014 ◽  
Vol 12 (7) ◽  
pp. 4148-4164 ◽  
Author(s):  
Wei Zhang ◽  
Jiang-Yuan Du ◽  
Zedong Jiang ◽  
Takasi Okimura ◽  
Tatsuya Oda ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Immune Responses ◽  
Ascophyllum Nodosum ◽  
Dendritic Cell Maturation ◽  
Cell Maturation

SulfatedRadix Cyathulae officinalisPolysaccharides Act as Adjuvant via Promoting the Dendritic Cell Maturation and Suppressing Treg Frequency

2015 ◽  
Vol 44 (3) ◽  
pp. 288-308 ◽  
Author(s):  
Haibo Feng ◽  
Jing Fan ◽  
Xiaogang Du ◽  
Zhenhui Song ◽  
Zhenhua Wang ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Dendritic Cell Maturation ◽  
Cell Maturation ◽  
Treg Frequency

scholarly journals DC-SIGN ligation on dendritic cells results in ERK and PI3K activation and modulates cytokine production

Blood ◽  
2006 ◽  
Vol 107 (10) ◽  
pp. 3950-3958 ◽  
Author(s):  
Esther Caparrós ◽  
Pilar Munoz ◽  
Elena Sierra-Filardi ◽  
Diego Serrano-Gómez ◽  
Amaya Puig-Kröger ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Dendritic Cell ◽  
Immune Responses ◽  
Tyrosine Kinases ◽  
Intracellular Signaling ◽  
Fungal Pathogens ◽  
Dendritic Cell Maturation ◽  
Cell Maturation ◽  
Myeloid Dendritic Cells ◽  
Akt Phosphorylation

The generation of pathogen-specific immune responses is dependent on the signaling capabilities of pathogen-recognition receptors. DC-SIGN is a C-type lectin that mediates capture and internalization of viral, bacterial, and fungal pathogens by myeloid dendritic cells. DC-SIGN–interacting pathogens are thought to modulate dendritic cell maturation by interfering with intracellular signaling from Toll-like receptor molecules. We report that engagement of DC-SIGN by specific antibodies does not promote dendritic cell maturation but induces ERK1/2 and Akt phosphorylation without concomitant p38MAPK activation. DC-SIGN ligation also triggers PLCγ phosphorylation and transient increases in intracellular calcium in dendritic cells. In agreement with its signaling capabilities, a fraction of DC-SIGN molecules partitions within lipid raft–enriched membrane fractions both in DC-SIGN–transfected and dendritic cells. Moreover, DC-SIGN in dendritic cells coprecipitates with the tyrosine kinases Lyn and Syk. The relevance of the DC-SIGN–initiated signals was demonstrated in monocyte-derived dendritic cells, as DC-SIGN cross-linking synergizes with TNF-α for IL-10 release and enhances the production of LPS-induced IL-10. These results demonstrate that DC-SIGN–triggered intracellular signals modulate dendritic cell maturation. Since pathogens stimulate Th2 responses via preferential activation of ERK1/2, these results provide a molecular explanation for the ability of DC-SIGN–interacting pathogens to preferentially evoke Th2-type immune responses.

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