Alantolactone suppresses inducible nitric oxide synthase and cyclooxygenase-2 expression by down-regulating NF-κB, MAPK and AP-1 via the MyD88 signaling pathway in LPS-activated RAW 264.7 cells

Jaemoo Chun; Ran Joo Choi; Salman Khan; Dong-Sung Lee; Youn-Chul Kim; Young-Joo Nam; Dong-Ung Lee; Yeong Shik Kim

doi:10.1016/j.intimp.2012.08.011

Alantolactone suppresses inducible nitric oxide synthase and cyclooxygenase-2 expression by down-regulating NF-κB, MAPK and AP-1 via the MyD88 signaling pathway in LPS-activated RAW 264.7 cells

International Immunopharmacology ◽

10.1016/j.intimp.2012.08.011 ◽

2012 ◽

Vol 14 (4) ◽

pp. 375-383 ◽

Cited By ~ 103

Author(s):

Jaemoo Chun ◽

Ran Joo Choi ◽

Salman Khan ◽

Dong-Sung Lee ◽

Youn-Chul Kim ◽

...

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Signaling Pathway ◽

Inducible Nitric Oxide Synthase ◽

Cyclooxygenase 2 ◽

Raw 264.7 Cells ◽

Raw 264.7 ◽

Myd88 Signaling ◽

Oxide Synthase ◽

Inducible Nitric Oxide

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Soybean glyceollins mitigate inducible nitric oxide synthase and cyclooxygenase-2 expression levels via suppression of the NF-κB signaling pathway in RAW 264.7 cells

International Journal of Molecular Medicine ◽

10.3892/ijmm.2012.887 ◽

2012 ◽

Vol 29 (4) ◽

pp. 711-717 ◽

Cited By ~ 18

Author(s):

EUN-KYUNG YOON ◽

HYUN-KYOUNG KIM ◽

SONG CUI ◽

YONG-HOON KIM ◽

SANG-HAN LEE

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Signaling Pathway ◽

Inducible Nitric Oxide Synthase ◽

Cyclooxygenase 2 ◽

Raw 264.7 Cells ◽

Raw 264.7 ◽

Expression Levels ◽

Oxide Synthase ◽

Inducible Nitric Oxide

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Effect of wogonin, a plant flavone from Scutellaria radix, on the suppression of cyclooxygenase-2 and the induction of inducible nitric oxide synthase in lipopolysaccharide-treated RAW 264.7 cells

Biochemical Pharmacology ◽

10.1016/s0006-2952(01)00597-4 ◽

2001 ◽

Vol 61 (10) ◽

pp. 1195-1203 ◽

Cited By ~ 135

Author(s):

Yeon Sook Chi ◽

Bong Sun Cheon ◽

Hyun Pyo Kim

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Inducible Nitric Oxide Synthase ◽

Cyclooxygenase 2 ◽

Raw 264.7 Cells ◽

Raw 264.7 ◽

Oxide Synthase ◽

Inducible Nitric Oxide

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Differential regulation of inducible nitric oxide synthase and cyclooxygenase-2 expression by superoxide dismutase in lipopolysaccharide stimulated RAW 264.7 cells

Experimental & Molecular Medicine ◽

10.3858/emm.2009.41.9.069 ◽

2009 ◽

Vol 41 (9) ◽

pp. 629 ◽

Cited By ~ 25

Author(s):

Ji Ae Lee ◽

Ha Yong Song ◽

Sung Mi Ju ◽

Su Jin Lee ◽

Hyung-Joo Kwon ◽

...

Keyword(s):

Nitric Oxide ◽

Superoxide Dismutase ◽

Nitric Oxide Synthase ◽

Inducible Nitric Oxide Synthase ◽

Differential Regulation ◽

Cyclooxygenase 2 ◽

Raw 264.7 Cells ◽

Raw 264.7 ◽

Oxide Synthase ◽

Inducible Nitric Oxide

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Suppression of lipopolysaccharide-induced of inducible nitric oxide synthase and cyclooxygenase-2 by Sanguis Draconis, a dragon's blood resin, in RAW 264.7 cells

Journal of Ethnopharmacology ◽

10.1016/j.jep.2007.10.012 ◽

2008 ◽

Vol 115 (3) ◽

pp. 455-462 ◽

Cited By ~ 45

Author(s):

Cheuk-Sing Choy ◽

Chien-Ming Hu ◽

Wen-Ta Chiu ◽

Carlos-Shu Kei Lam ◽

Yih Ting ◽

...

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Inducible Nitric Oxide Synthase ◽

Cyclooxygenase 2 ◽

Raw 264.7 Cells ◽

Raw 264.7 ◽

Dragon’S Blood ◽

Oxide Synthase ◽

Inducible Nitric Oxide

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Suppression of cyclooxygenase-2 and inducible nitric oxide synthase expression by epimuqubilin A via IKK/IκB/NF-κB pathways in lipopolysaccharide-stimulated RAW 264.7 cells

Phytochemistry Letters ◽

10.1016/j.phytol.2011.07.009 ◽

2011 ◽

Vol 4 (4) ◽

pp. 426-431 ◽

Cited By ~ 15

Author(s):

Eun-Jung Park ◽

Sarot Cheenpracha ◽

Leng Chee Chang ◽

John M. Pezzuto

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Inducible Nitric Oxide Synthase ◽

Cyclooxygenase 2 ◽

Raw 264.7 Cells ◽

Raw 264.7 ◽

Oxide Synthase ◽

Inducible Nitric Oxide

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Catalase induces the expression of inducible nitric oxide synthase through activation of NF-κB and PI3K signaling pathway in Raw 264.7 cells

Biochemical Pharmacology ◽

10.1016/j.bcp.2004.08.008 ◽

2004 ◽

Vol 68 (11) ◽

pp. 2167-2176 ◽

Cited By ~ 17

Author(s):

Byeong-Churl Jang ◽

Ji-Hye Paik ◽

Sang-Pyo Kim ◽

Jae-Hoon Bae ◽

Kyo-Chul Mun ◽

...

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Signaling Pathway ◽

Inducible Nitric Oxide Synthase ◽

Raw 264.7 Cells ◽

Raw 264.7 ◽

Pi3k Signaling ◽

Pi3k Signaling Pathway ◽

Oxide Synthase ◽

Inducible Nitric Oxide

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Anti-inflammatory Activity of the Synthetic Chalcone Derivatives: Inhibition of Inducible Nitric Oxide Synthase-Catalyzed Nitric Oxide Production from Lipopolysaccharide-Treated RAW 264.7 Cells

Biological and Pharmaceutical Bulletin ◽

10.1248/bpb.30.1450 ◽

2007 ◽

Vol 30 (8) ◽

pp. 1450-1455 ◽

Cited By ~ 43

Author(s):

Young Hoon Kim ◽

Jeongsoo Kim ◽

Haeil Park ◽

Hyun Pyo Kim

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Inducible Nitric Oxide Synthase ◽

Inflammatory Activity ◽

Raw 264.7 Cells ◽

Raw 264.7 ◽

Nitric Oxide Production ◽

Oxide Production ◽

Oxide Synthase ◽

Inducible Nitric Oxide

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Mechanisms of suppression of inducible nitric oxide synthase (iNOS) expression in RAW 264.7 cells by andrographolide

British Journal of Pharmacology ◽

10.1038/sj.bjp.0703191 ◽

2000 ◽

Vol 129 (8) ◽

pp. 1553-1560 ◽

Cited By ~ 111

Author(s):

Wen-Fei Chiou ◽

Chieh-Fu Chen ◽

Jin-Jung Lin

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Inducible Nitric Oxide Synthase ◽

Inos Expression ◽

Raw 264.7 Cells ◽

Raw 264.7 ◽

Oxide Synthase ◽

Inducible Nitric Oxide

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Tanshinone IIA fromSalvia miltiorrhizaInhibits Inducible Nitric Oxide Synthase Expression and Production of TNF-α, IL-1β and IL-6 in Activated RAW 264.7 Cells

Planta Medica ◽

10.1055/s-2003-45157 ◽

2003 ◽

Vol 69 (11) ◽

pp. 1057-1059 ◽

Cited By ~ 139

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Inducible Nitric Oxide Synthase ◽

Tanshinone Iia ◽

Raw 264.7 Cells ◽

Raw 264.7 ◽

Tnf Α ◽

Oxide Synthase ◽

Inducible Nitric Oxide

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Anti-inflammatory effects of flavonoids in Korean Chrysanthemum species via suppression of inducible nitric oxide synthase and cyclooxygenase-2 in LPS-induced RAW 264.7 macrophages

Food Science and Biotechnology ◽

10.1007/s10068-015-0125-9 ◽

2015 ◽

Vol 24 (3) ◽

pp. 975-985 ◽

Cited By ~ 7

Author(s):

Su Jeong Kim ◽

Kyung-Tae Lee ◽

Hye-Eun Choi ◽

Tae Joung Ha ◽

Jung Hwan Nam ◽

...

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Inducible Nitric Oxide Synthase ◽

Cyclooxygenase 2 ◽

Raw 264.7 ◽

Raw 264.7 Macrophages ◽

Anti Inflammatory ◽

Oxide Synthase ◽

Inducible Nitric Oxide

Download Full-text