Identification of HLA-A*0201-restricted CD8+ T-cell epitope C64–72 from hepatitis B virus core protein

2012 ◽  
Vol 13 (2) ◽  
pp. 141-147 ◽  
Author(s):  
Qiuyan Liu ◽  
Yuanyuan Zheng ◽  
Yizhi Yu ◽  
Qinchun Tan ◽  
Xinping Huang
Keyword(s):  
Hepatitis B Virus ◽  
T Cell ◽  
Hepatitis B ◽  
Core Protein ◽  
Cell Epitope ◽  
Cd8 T Cell ◽  
T Cell Epitope ◽  
Virus Core ◽  
B Virus

scholarly journals Adaptation of the hepatitis B virus core protein to CD8+T-cell selection pressure

Hepatology ◽  
2015 ◽  
Vol 62 (1) ◽  
pp. 47-56 ◽  
Author(s):  
Helenie Kefalakes ◽  
Bettina Budeus ◽  
Andreas Walker ◽  
Christoph Jochum ◽  
Gudrun Hilgard ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
T Cell ◽  
Hepatitis B ◽  
Selection Pressure ◽  
Core Protein ◽  
Cd8 T Cell ◽  
Cell Selection ◽  
Virus Core ◽  
B Virus ◽  
T Cell Selection

Molecular features of the hepatitis B virus nucleocapsid T-cell epitope 18-27: Interaction with HLA and T-cell receptor

Hepatology ◽  
1997 ◽  
Vol 26 (4) ◽  
pp. 1027-1034 ◽  
Author(s):  
A Bertoletti ◽  
S Southwood ◽  
R Chesnut ◽  
A Sette ◽  
M Falco ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
T Cell ◽  
Hepatitis B ◽  
T Cell Receptor ◽  
Cell Epitope ◽  
Cell Receptor ◽  
T Cell Epitope ◽  
Molecular Features ◽  
B Virus

scholarly journals Naturally Occurring Hepatitis B Virus B-Cell and T-Cell Epitope Mutants in Hepatitis B Vaccinated Children

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Yu-Min Lin ◽  
Guey-Mei Jow ◽  
Shu-Chi Mu ◽  
Bing-Fang Chen
Keyword(s):  
Hepatitis B Virus ◽  
T Cell ◽  
Hepatitis B ◽  
B Cell ◽  
Cell Epitope ◽  
Hbv Infection ◽  
Core Antigen ◽  
T Cell Epitope ◽  
Naturally Occurring ◽  
B Virus

To control hepatitis B virus (HBV) infection, a universal HBV vaccination program for infants was launched in Taiwan in 1984. The aim of this study was to investigate the role of B-cell and T-cell epitope variations of HBsAg and polymerase in HBV infection in vaccinated children. One hundred sixty-three sera from vaccinated children were enrolled randomly. HBV serum markers, including hepatitis B surface antigen (HBsAg) and antibodies to HBsAg (anti-HBs) and core antigen (anti-HBc), were detected by ELISA. Nucleotide sequences encoding the S and the pre-S regions of HBsAg were analyzed in all HBsAg positive sera. Five children were HBsAg positive. Sequence analysis of S, pre-S, and overlapped polymerase (P) genes showed that HBV isolates of HBsAg-positive vaccinees were variants; no G145R but G145A and other substitutions were found in the “a” determinant. Fifteen, six, and eight amino acid substitutions within B-cell and T-cell epitopes of S, pre-S, and P regions were detected, respectively. Several immune-epitope mutants, such as S45T/A, N131T, I194V, and S207N in S, were detected in all isolates. In conclusion, our results suggested that these naturally occurring immunoepitope mutants, which changed their immunogenicity leading to escape from immune response, might cause HBV infection.

scholarly journals Definition of a minimal optimal cytotoxic T-cell epitope within the hepatitis B virus nucleocapsid protein.

1993 ◽  
Vol 67 (4) ◽  
pp. 2376-2380 ◽  
Author(s):  
A Bertoletti ◽  
F V Chisari ◽  
A Penna ◽  
S Guilhot ◽  
L Galati ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
T Cell ◽  
Hepatitis B ◽  
Nucleocapsid Protein ◽  
Cell Epitope ◽  
Cytotoxic T Cell ◽  
T Cell Epitope ◽  
B Virus ◽  
Definition Of

Immunomodulation and RNA interference alter Hepatitis B Virus‐specific CD8 T cell recognition of infected HepG2‐NTCP

Hepatology ◽  
2021 ◽  
Author(s):  
Adrian Kuipery ◽  
Juan Diego Sanchez Vasquez ◽  
Aman Mehrotra ◽  
Jordan J. Feld ◽  
Harry L. A. Janssen ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Rna Interference ◽  
T Cell ◽  
Hepatitis B ◽  
Cd8 T Cell ◽  
Cell Recognition ◽  
T Cell Recognition ◽  
B Virus
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