scholarly journals Protective effect of Artin M from extract of Artocarpus integrifolia seeds by Th1 and Th17 immune response on the course of infection by Candida albicans

2011 ◽  
Vol 11 (10) ◽  
pp. 1510-1515 ◽  
Author(s):  
Luiz Antonio Custodio ◽  
Wagner Loyola ◽  
Ivete Conchon-Costa ◽  
Gustavo Fernando da Silva Quirino ◽  
Ionice Felipe
Keyword(s):  
Immune Response ◽  
Candida Albicans ◽  
Protective Effect ◽  
Artocarpus Integrifolia

Double positive CD4+CD8+ T cells are part of the adaptive immune response against Candida albicans

2019 ◽  
Vol 80 (12) ◽  
pp. 999-1005 ◽  
Author(s):  
Barbara Misme-Aucouturier ◽  
Adel Touahri ◽  
Marjorie Albassier ◽  
Francine Jotereau ◽  
Patrice Le Pape ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cells ◽  
Candida Albicans ◽  
Cd8 T Cells ◽  
Adaptive Immune Response ◽  
Double Positive ◽  
Adaptive Immune

scholarly journals Phagocytes from Mice Lacking the Sts Phosphatases Have an Enhanced Antifungal Response to Candida albicans

mBio ◽  
2018 ◽  
Vol 9 (4) ◽  
Author(s):  
David Frank ◽  
Shamoon Naseem ◽  
Gian Luigi Russo ◽  
Cindy Li ◽  
Kaustubh Parashar ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Immune Response ◽  
Candida Albicans ◽  
Tyrosine Kinase ◽  
Critical Role ◽  
Inflammasome Activation ◽  
Wild Type ◽  
Content Type ◽  
Enhanced Production ◽  
Immunological Mechanisms

ABSTRACT Mice lacking expression of the homologous phosphatases Sts-1 and Sts-2 (Sts−/− mice) are resistant to disseminated candidiasis caused by the fungal pathogen Candida albicans. To better understand the immunological mechanisms underlying the enhanced resistance of Sts−/− mice, we examined the kinetics of fungal clearance at early time points. In contrast to the rapid C. albicans growth seen in normal kidneys during the first 24 h postinfection, we observed a reduction in kidney fungal CFU within Sts−/− mice beginning at 12 to 18 h postinfection. This corresponds to the time period when large numbers of innate leukocytes enter the renal environment to counter the infection. Because phagocytes of the innate immune system are important for host protection against pathogenic fungi, we evaluated responses of bone marrow leukocytes. Relative to wild-type cells, Sts−/− marrow monocytes and bone marrow-derived dendritic cells (BMDCs) displayed a heightened ability to inhibit C. albicans growth ex vivo. This correlated with significantly enhanced production of reactive oxygen species (ROS) by Sts−/− BMDCs downstream of Dectin-1, a C-type lectin receptor that plays a critical role in stimulating host responses to fungi. We observed no visible differences in the responses of other antifungal effector pathways, including cytokine production and inflammasome activation, despite enhanced activation of the Syk tyrosine kinase downstream of Dectin-1 in Sts−/− cells. Our results highlight a novel mechanism regulating the immune response to fungal infections. Further understanding of this regulatory pathway could aid the development of therapeutic approaches to enhance protection against invasive candidiasis. IMPORTANCE Systemic candidiasis caused by fungal Candida species is becoming an increasingly serious medical problem for which current treatment is inadequate. Recently, the Sts phosphatases were established as key regulators of the host antifungal immune response. In particular, genetic inactivation of Sts significantly enhanced survival of mice infected intravenously with Candida albicans. The Sts−/− in vivo resistance phenotype is associated with reduced fungal burden and an absence of inflammatory lesions. To understand the underlying mechanisms, we studied phagocyte responses. Here, we demonstrate that Sts−/− phagocytes have heightened responsiveness to C. albicans challenge relative to wild-type cells. Our data indicate the Sts proteins negatively regulate phagocyte activation via regulating selective elements of the Dectin-1–Syk tyrosine kinase signaling axis. These results suggest that phagocytes lacking Sts respond to fungal challenge more effectively and that this enhanced responsiveness partially underlies the profound resistance of Sts−/− mice to systemic fungal challenge.

scholarly journals Immunomodulatory action of jacalin from Artocarpus integrifolia and mannoprotein from Saccharomyces uvarum on the humoral immunity of laying hens

2020 ◽  
Vol 50 (4) ◽  
Author(s):  
Marco Aurélio Chiara Silva ◽  
Miriele Caroline da Silva ◽  
João Waine Pinheiro ◽  
Raul Jorge Hernan Castro-Goméz ◽  
Alice Eiko Murakami ◽  
...  
Keyword(s):  
Immune Response ◽  
Protein Interactions ◽  
Antibody Production ◽  
Laying Hens ◽  
Lectin Binding ◽  
Primary Immune Response ◽  
Immunomodulatory Effects ◽  
Saccharomyces Uvarum ◽  
Immunomodulatory Properties ◽  
Artocarpus Integrifolia

ABSTRACT: Advances in the fields of glycobiology and immunology have provided many insights into the role of carbohydrate-protein interactions in the immune system. Jacalin of Artocarpus integrifolia (JCA) and structural mannoprotein of Saccharomyces uvarum (MPS) are molecules with immunomodulatory properties. JCA is an IgA human lectin binding molecule that causes the mitogenic stimulation of immune cells, production of cytokines, chemotaxis, and activation of leukocytes. Studies on the immunomodulatory properties of JCA and MPS in mammals and fish suggest that they have an action on antibody production. The aim of this study was to investigate the possible action of JCA and MPS on the production of specific antibodies in laying hens. For this, laying hens were inoculated with an intra abdominal injection of sheep red blood cells (SRBC) with either JCA (0.075 µg, 0.75 µg, and 7.5 µg) or MPS (20 µg and 100 µg). Levels of anti-SRBC antibodies of the IgY, IgM, and IgA classes were evaluated by ELISA. Results showed that JCA and MPS have immunomodulatory effects on levels of anti-SRBC IgM, IgA, and IgY. An immunostimulatory effect of JCA was observed in primary immune response on anti-SRBC IgY, while an inhibitory effect of JCA and MPS was observed in secondary immune response on the production of IgM and IgA anti-SRBC. These results suggested that MPS and JCA have immunomodulatory effects on antibody production and could be used in future studies on humoral immune response in poultry.

scholarly journals Modulatory role of vitamin A on the Candida albicans-induced immune response in human monocytes

2014 ◽  
Vol 203 (6) ◽  
pp. 415-424 ◽  
Author(s):  
Tilman E. Klassert ◽  
Anja Hanisch ◽  
Julia Bräuer ◽  
Esther Klaile ◽  
Kerstin A. Heyl ◽  
...  
Keyword(s):  
Immune Response ◽  
Candida Albicans ◽  
Vitamin A ◽  
Human Monocytes

scholarly journals Reduced PICD in Monocytes Mounts Altered Neonate Immune Response to Candida albicans

PLoS ONE ◽  
2016 ◽  
Vol 11 (11) ◽  
pp. e0166648 ◽  
Author(s):  
Stephan Dreschers ◽  
Peter Saupp ◽  
Mathias Hornef ◽  
Andrea Prehn ◽  
Christopher Platen ◽  
...  
Keyword(s):  
Immune Response ◽  
Candida Albicans

scholarly journals CpG Oligodeoxynucleotides Increase the Susceptibility of Normal Mice to Infection by Candida albicans

2005 ◽  
Vol 73 (9) ◽  
pp. 6154-6156 ◽  
Author(s):  
Shuichi Ito ◽  
Joao Pedras-Vasconcelos ◽  
Dennis M. Klinman
Keyword(s):  
Immune Response ◽  
Candida Albicans ◽  
Innate Immune Response ◽  
Host Resistance ◽  
Cytokine Production ◽  
Innate Immune ◽  
Interleukin 12 ◽  
Cpg Oligodeoxynucleotides ◽  
Cpg Motifs ◽  
Resistance To Infection

ABSTRACT Synthetic oligodeoxynucleotides containing CpG motifs trigger an innate immune response that typically increases host resistance to infection. Yet CpG treatment reduces the resistance of normal mice to Candida albicans infection. This effect is mediated by CpG-induced interleukin-12, indicating that CpG-dependent cytokine production may have adverse consequences for the host.

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