Endogenous lectins shape the function of dendritic cells and tailor adaptive immunity: Mechanisms and biomedical applications

2011 ◽  
Vol 11 (7) ◽  
pp. 833-841 ◽  
Author(s):  
Iván D. Mascanfroni ◽  
Juan P. Cerliani ◽  
Sebastián Dergan-Dylon ◽  
Diego O. Croci ◽  
Juan M. Ilarregui ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Adaptive Immunity ◽  
Biomedical Applications ◽  
Endogenous Lectins

Innate Vα14+natural killer T cells mature dendritic cells, leading to strong adaptive immunity

2007 ◽  
Vol 220 (1) ◽  
pp. 183-198 ◽  
Author(s):  
Shin-Ichiro Fujii ◽  
Kanako Shimizu ◽  
Hiroaki Hemmi ◽  
Ralph M. Steinman
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Natural Killer ◽  
Adaptive Immunity ◽  
Natural Killer T Cells ◽  
Killer T Cells ◽  
Natural Killer T

scholarly journals 5-Lipoxygenase Pathway, Dendritic Cells, and Adaptive Immunity

2004 ◽  
Vol 2004 (2) ◽  
pp. 99-105 ◽  
Author(s):  
Harizi Hedi ◽  
Gualde Norbert
Keyword(s):  
Dendritic Cells ◽  
Adaptive Immunity ◽  
Inflammatory Cells ◽  
Lipid Mediators ◽  
G Protein Coupled Receptors ◽  
Lipoxygenase Pathway ◽  
Innate And Adaptive Immunity ◽  
Paracrine Signalling ◽  
Signalling Molecules ◽  
G Protein Coupled

5-lipoxygenase (5-LO) pathway is the major source of potent proinflammatory leukotrienes (LTs) issued from the metabolism of arachidonic acid (AA), and best known for their roles in the pathogenesis of asthma. These lipid mediators are mainly released from myeloid cells and may act as physiological autocrine and paracrine signalling molecules, and play a central role in regulating the interaction between innate and adaptive immunity. The biological actions of LTs including their immunoregulatory and proinflammatory effects are mediated through extracellular specific G-protein-coupled receptors. Despite their role in inflammatory cells, such as neutrophils and macrophages, LTs may have important effects on dendritic cells (DC)-mediated adaptive immunity. Several lines of evidence show that DC not only are important source of LTs, but also become targets of their actions by producing other lipid mediators and proinflammatory molecules. This review focuses on advances in 5-LO pathway biology, the production of LTs from DC and their role on various cells of immune system and in adaptive immunity.

scholarly journals Staphylococcus aureusImpairs the Function of and Kills Human Dendritic Cells via the LukAB Toxin

mBio ◽  
2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Evelien T. M. Berends ◽  
Xuhui Zheng ◽  
Erin E. Zwack ◽  
Mickaël M. Ménager ◽  
Michael Cammer ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Dendritic Cells ◽  
Adaptive Immunity ◽  
T Cell Activation ◽  
Antigen Presenting Cells ◽  
Infection Model ◽  
High Morbidity ◽  
Content Type ◽  
Human Dendritic Cells ◽  
Antigen Presenting

ABSTRACTStaphylococcus aureusis a human pathogen responsible for high morbidity and mortality worldwide. Recurrent infections with this bacterium are common, suggesting thatS. aureusthwarts the development of sterilizing immunity.S. aureusstrains that cause disease in humans produce up to five different bicomponent toxins (leukocidins) that target and lyse neutrophils, innate immune cells that represent the first line of defense againstS. aureusinfections. However, little is known about the role of leukocidins in blunting adaptive immunity. Here, we explored the effects of leukocidins on human dendritic cells (DCs), antigen-presenting cells required for the development of adaptive immunity. Using anex vivoinfection model of primary human monocyte-derived dendritic cells, we found thatS. aureus, including strains from different clonal complexes and drug resistance profiles, effectively kills DCs despite efficient phagocytosis. Although all purified leukocidins could kill DCs, infections with live bacteria revealed thatS. aureustargets and kills DCs primarily via the activity of leukocidin LukAB. Moreover, using coculture experiments performed with DCs and autologous CD4+T lymphocytes, we found that LukAB inhibits DC-mediated activation and proliferation of primary human T cells. Taken together, the data determined in the study reveal a novel immunosuppressive strategy ofS. aureuswhereby the bacterium blunts the development of adaptive immunity via LukAB-mediated injury of DCs.IMPORTANCEAntigen-presenting cells such as dendritic cells (DCs) fulfill an indispensable role in the development of adaptive immunity by producing proinflammatory cytokines and presenting microbial antigens to lymphocytes to trigger a faster, specific, and long-lasting immune response. Here, we studied the effect ofStaphylococcus aureustoxins on human DCs. We discovered that the leukocidin LukAB hinders the development of adaptive immunity by targeting human DCs. The ability ofS. aureusto blunt the function of DCs could help explain the high frequency of recurrentS. aureusinfections. Taken together, the results from this study suggest that therapeutically targeting theS. aureusleukocidins may boost effective innate and adaptive immune responses by protecting innate leukocytes, enabling proper antigen presentation and T cell activation.

scholarly journals Amplifying IFN-γ Signaling in Dendritic Cells by CD11c-Specific Loss of SOCS1 Increases Innate Immunity to Infection while Decreasing Adaptive Immunity

2017 ◽  
Vol 200 (1) ◽  
pp. 177-185 ◽  
Author(s):  
Alejandro F. Alice ◽  
Gwen Kramer ◽  
Shelly Bambina ◽  
Jason R. Baird ◽  
Keith S. Bahjat ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Dendritic Cells ◽  
Adaptive Immunity ◽  
Specific Loss ◽  
Ifn Γ

AIRE expressing marginal zone dendritic cells balances adaptive immunity and T-follicular helper cell recruitment

2013 ◽  
Vol 42 ◽  
pp. 62-70 ◽  
Author(s):  
Evelina Lindmark ◽  
Yunying Chen ◽  
Anna-Maria Georgoudaki ◽  
Diana Dudziak ◽  
Emma Lindh ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Adaptive Immunity ◽  
Marginal Zone ◽  
Helper Cell ◽  
Cell Recruitment ◽  
Follicular Helper ◽  
T Follicular Helper Cell

scholarly journals NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells

Nature ◽  
2012 ◽  
Vol 484 (7395) ◽  
pp. 510-513 ◽  
Author(s):  
Stephanie C. Eisenbarth ◽  
Adam Williams ◽  
Oscar R. Colegio ◽  
Hailong Meng ◽  
Till Strowig ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Adaptive Immunity
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