(5R)-5-hydroxytriptolide inhibits the immune response of human peripheral blood mononuclear cells

2009 ◽  
Vol 9 (1) ◽  
pp. 63-69 ◽  
Author(s):  
Ru Zhou ◽  
Wei Tang ◽  
Pei-Lan He ◽  
Yi-Fu Yang ◽  
Yuan-Chao Li ◽  
...  
Keyword(s):  
Immune Response ◽  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Human Peripheral Blood ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells

scholarly journals Bisphenol A suppresses Th1-type immune response in human peripheral blood mononuclear cells in vitro

2015 ◽  
Vol 168 (2) ◽  
pp. 285-292 ◽  
Author(s):  
Johanna M. Gostner ◽  
Emanuel Raggl ◽  
Kathrin Becker ◽  
Florian Überall ◽  
Harald Schennach ◽  
...  
Keyword(s):  
Immune Response ◽  
Bisphenol A ◽  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Human Peripheral Blood ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells

scholarly journals Colonic Bacteria-Transformed Catechin Metabolite Response to Cytokine Production by Human Peripheral Blood Mononuclear Cells

Biomolecules ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 830 ◽  
Author(s):  
Rajapandiyan Krishnamoorthy ◽  
Abdulraheem R. Adisa ◽  
Vaiyapuri Subbarayan Periasamy ◽  
Jegan Athinarayanan ◽  
Subash-Babu Pandurangan ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Immune Response ◽  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Human Peripheral Blood ◽  
Peripheral Blood Mononuclear ◽  
Chromatography Mass Spectrometry ◽  
Blood Mononuclear Cells ◽  
Anti Inflammatory

Human gut microbes are a profitable tool for the modification of food compounds into biologically active metabolites. The biological properties of catechins have been extensively investigated. However, the bioavailability of catechin in human blood plasma is very low. This study aimed to determine the biotransformed catechin metabolites and their bioactive potentials for modulating the immune response of human peripheral blood mononuclear cells (PBMCs). Biotransformation of catechin was carried out using in-vitro gut microbial biotransformation method, the transformed metabolites were identified and confirmed by gas chromatography-mass spectrometry (GC–MS) and high-performance liquid chromatography-mass spectrometry (HPLC–MS). Present observations confirmed that the catechin was biotransformed into 11 metabolites upon microbial dehydroxylation and C ring cleavage. Further, immunomodulatory potential of catechin metabolites was analyzed in peripheral blood mononuclear cells (PBMCs). We found up-regulation of anti-inflammatory cytokine (IL-4, IL-10) and down-regulation of pro-inflammatory (IL-16, IL-12B) cytokine may be due to Th2 immune response. In conclusion, biotransformed catechin metabolites enhance anti-inflammatory cytokines which is beneficial for overcoming inflammatory disorders.

scholarly journals LL-37 treatment on human peripheral blood mononuclear cells modulates immune response and promotes regulatory T-cells generation

2018 ◽  
Vol 108 ◽  
pp. 1584-1590 ◽  
Author(s):  
Dominique Sternadt Alexandre-Ramos ◽  
Amandda Évelin Silva-Carvalho ◽  
Mariella Guimarães Lacerda ◽  
Teresa Raquel Tavares Serejo ◽  
Octávio Luiz Franco ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cells ◽  
Regulatory T Cells ◽  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Human Peripheral Blood ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells
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