Effects on gene expression and viral load of a medicinal extract from Agaricus blazei in patients with chronic hepatitis C infection

2006 ◽  
Vol 6 (8) ◽  
pp. 1311-1314 ◽  
Author(s):  
B. Grinde ◽  
G. Hetland ◽  
E. Johnson
Keyword(s):  
Gene Expression ◽  
Chronic Hepatitis ◽  
Viral Load ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Agaricus Blazei ◽  
Hepatitis C Infection

Cell surface expression of LDL receptor in chronic hepatitis C: correlation with viral load

2007 ◽  
Vol 293 (1) ◽  
pp. E416-E420 ◽  
Author(s):  
Jean-Michel Petit ◽  
Anne Minello ◽  
Laurence Duvillard ◽  
Valérie Jooste ◽  
Serge Monier ◽  
...  
Keyword(s):  
Gene Expression ◽  
Chronic Hepatitis ◽  
Viral Load ◽  
Hepatitis C ◽  
Cell Surface ◽  
Chronic Hepatitis C ◽  
Mononuclear Cells ◽  
Ldl Receptor ◽  
Surface Expression ◽  
Cell Surface Expression

The LDL receptor (LDL-R) has been proposed as the viral receptor for Hepatitis C virus (HCV). This hypothesis has been based exclusively on in vitro studies. In human mononuclear cells, LDL-R gene expression has been demonstrated to be parallel and be coordinately regulated to gene expression in the human liver. The purpose of the current study was to determine the mononuclear cell surface expression of the LDL receptor in patients with HCV chronic infection according to viral load. Sixty-eight consecutive untreated chronic hepatitis C patients were studied to determine the mononuclear cell surface expression of the LDL-R. LDL-Rs were quantified at the surface of mononuclear cells in fresh blood samples taken after fasting using flow cytometry. LDL-R expression was significantly associated with LDL-cholesterol ( r = −0.25; P = 0.03) and HCV-viral load ( r = 0.37, P = 0.002). In multivariate analysis, the LDL-R expression was significantly associated with HCV viral load, whereas genotype, age, body mass index, and fibrosis were not. In conclusion, our data provided by a human study, suggest that the LDL-R may be one of the receptors implicated in HCV replication.

The impact of antihyperlipidemic drugs on the viral load of patients with chronic hepatitis C infection: a meta-analysis

2014 ◽  
Vol 21 (8) ◽  
pp. 533-541 ◽  
Author(s):  
G. Grammatikos ◽  
H. Farnik ◽  
D. Bon ◽  
A. Böhlig ◽  
T. Bader ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Viral Load ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Meta Analysis ◽  
Hepatitis C Infection ◽  
The Impact

Chronic hepatitis C infection: Influence of the viral load, genotypes, and GBV-C/HGV coinfection on the severity of the disease in a Brazilian population

2002 ◽  
Vol 67 (1) ◽  
pp. 27-32 ◽  
Author(s):  
Leila M.M.B. Pereira ◽  
Victorino Spinelli ◽  
Ricardo A. Ximenes ◽  
Maria S. Cavalcanti ◽  
Raul Melo ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Viral Load ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Brazilian Population ◽  
Hepatitis C Infection ◽  
Severity Of The Disease

scholarly journals A Case of Severe Acute Respiratory Syndrome Coronavirus 2 Treatment With Remdesivir in a Hepatitis C-Coinfected Patient Resulting in Temporary Viral Control and Posttreatment Flare

2021 ◽  
Vol 8 (4) ◽  
Author(s):  
Maria Ribeiro da Cunha ◽  
Inês Coelho Rodrigues ◽  
Frederico Trigueiros ◽  
Luís Carlos Freitas ◽  
Sandra Braz ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Viral Load ◽  
Hepatitis C ◽  
Severe Acute Respiratory Syndrome ◽  
Chronic Hepatitis C ◽  
Concomitant Treatment ◽  
Hepatitis C Infection ◽  
Viral Control ◽  
Coinfected Patient

Abstract We report a case of a man with chronic hepatitis C infection treated with remdesivir for COVID-19, resulting in lowered HCV viral load, followed by a rebound after its discontinuation. Concomitant treatment with tocilizumab possibly caused loss of anti-HBs.

scholarly journals Hepatitis C Genotypes in Patients with Chronic Hepatitis C Infection: A Three-Year Evaluation

2020 ◽  
Vol 25 (3) ◽  
pp. 347-353
Author(s):  
Yasemin Derya Gülseren ◽  
Fatma Esenkaya Taşbent ◽  
Mehmet Özdemir ◽  
Bahadır Feyzioğlu
Keyword(s):  
Chronic Hepatitis ◽  
Viral Load ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Hcv Rna ◽  
Genotype Distribution ◽  
Hepatitis C Infection ◽  
Genotype 1B ◽  
Geographical Regions ◽  
Genotype 3A

Introduction: In case of chronic hepatitis C infection, cirrhosis and hepatocellular carcinoma may progress. HCV genotypes and subtypes have been found to vary according to geographical regions. In addition to its epidemiological importance, HCV genotype is an important factor in determining the response and duration of treatment. In this study, it was aimed to determine the genotype distribution in our region. Materials and Methods: The results of 241 patients with HCV RNA positivity detected in our laboratory Molecular unit between 2016 and 2018 were retrospectively screened. HCV-RNA extraction for genotyping was performed by automated system (EZ1 Virus Mini Kit v.2.0, Germany), and ‘’line probe assay’’ (LIPA) based on reverse hybridization method was applied. HCV-RNA levels were determined by real-time PCR method (Artus HCV QS-RGQ kit, Qiagen, Germany). Results: Two hundred and forty-one patients were included in the study, and 116 (48%) were females and 125 (52%) were males. Mean age was 56.1 ± 19.4 (range: 16-90) years. Mean logarithmic viral load value was 5.7 ± 0.9 IU/ml (range; 2.71 x 102-17 x 106), mean value of AST was 50.5 ± 43.7 IU/ml and mean ALT value was 63.4 ± 63.5 IU/ml. Genotype 1b was detected in 58.9% of the patients, genotype 3a in 14.1%, genotype 1a in 13.27%, genotype 2b in 4.1%, genotype 4a in 1.2%. The subtypes could not be determined for 4.9%, 1.2%, 1.6% and 0.4% of infected patient in genotype 1,2,4 and 5 respectively. Conclusion: In our study, genotype 1b (58.9%) was found as the dominant genotype. This was followed by genotype 3a (14.1%). In patients infected with genotype 1, viral load value was found to be significantly higher than other genotypes. Monitoring genotype change is important for determining treatment protocols and duration.

Sofosbuvir plus daclatasvir with or without ribavirin for chronic hepatitis C infection: Impact of drug concentration on viral load decay

2016 ◽  
Vol 48 (11) ◽  
pp. 1351-1356 ◽  
Author(s):  
Victor Virlogeux ◽  
Laure Choupeaux ◽  
Pierre Pradat ◽  
Marianne Maynard ◽  
François Bailly ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Viral Load ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Drug Concentration ◽  
Hepatitis C Infection

scholarly journals Evaluation of viral load in saliva from patients with chronic hepatitis C infection

2015 ◽  
Vol 8 (5) ◽  
pp. 474-480 ◽  
Author(s):  
Renata L. Xavier Santos ◽  
Dayse M.V. de Deus ◽  
Edmundo P. de Almeida Lopes ◽  
Maria R.C. Duarte Coêlho ◽  
Jurema F.L. de Castro
Keyword(s):  
Chronic Hepatitis ◽  
Viral Load ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Hepatitis C Infection
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