Anti-allergic activity of a Kampo (Japanese herbal) medicine “Sho-seiryu-to (Xiao-Qing-Long-Tang)” on airway inflammation in a mouse model

2004 ◽  
Vol 4 (10-11) ◽  
pp. 1353-1365 ◽  
Author(s):  
Takayuki Nagai ◽  
Yumiko Arai ◽  
Michiko Emori ◽  
Shin-yu Nunome ◽  
Takeshi Yabe ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Mouse Model ◽  
Airway Inflammation ◽  
Japanese Herbal Medicine

scholarly journals Proteomic Analysis of Anti-inflammatory Effects of a Kampo (Japanese Herbal) Medicine “Shoseiryuto (Xiao-Qing-Long-Tang)” on Airway Inflammation in a Mouse Model

2011 ◽  
Vol 2011 ◽  
pp. 1-13 ◽  
Author(s):  
Takayuki Nagai ◽  
Marino Nakao ◽  
Yuliko Shimizu ◽  
Yoshio Kodera ◽  
Masamichi Oh-Ishi ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Mouse Model ◽  
Airway Inflammation ◽  
Bronchial Asthma ◽  
Antibody Titer ◽  
Lung Tissue ◽  
Proteomic Analysis ◽  
Allergic Airway Inflammation ◽  
Airway Hyperreactivity ◽  
Japanese Herbal Medicine

Effects of a Kampo (Japanese herbal) medicine “shoseiryuto (SST, xiao-qing-long-tang in Chinese)”, which has been used for the treatment of allergic bronchial asthma clinically, were examined on ovalbumin (OVA)-sensitized allergic airway inflammation model (i.e., bronchial asthma) in a mouse. When SST was orally administered at 0.5 g kg−1 day−1from day 1 to 6 after OVA inhalation, SST reduced the inflammation in lung tissue, the number of eosinophils and the OVA-specific immunoglobulin E (IgE) antibody titer in bronchoalveolar lavage (BAL) fluids at 7 days after the OVA inhalation. SST also reduced the airway hyperreactivity at 6 days after the OVA inhalation. Proteomic analysis with the agarose two-dimensional electrophoresis showed that the expression of spectrin α2 was reduced in the lung tissue of OVA-sensitized mice and SST recovered the expression. Western blot and immunohistochemical analyses of lung tissue also confirmed this result. When prednisolone was orally administered at 3 mg kg−1 day−1from day 1 to 6 after OVA inhalation, the inflammation in lung tissue, the number of eosinophils in BAL fluids and airway hyperreactivity were reduced in the OVA-sensitized mice. However, prednisolone did not reduce the OVA-specific IgE antibody titer in BAL fluids and did not recover the expression of spectrin α2 in lung tissue. These results suggest that at least a part of action mechanism of SST against OVA-sensitized allergic airway inflammation in a mouse model is different from that of prednisolone.

A Japanese herbal medicine, Sho-saiko-to, prevents gut ischemia/reperfusion-induced hepatic microvascular dysfunction in rats

2001 ◽  
Vol 16 (11) ◽  
pp. 1260-1266 ◽  
Author(s):  
Yoshinori Horie ◽  
Mikio Kajihara ◽  
Yoshiyuki Yamagishi ◽  
Hiroyuki Kimura ◽  
Hironao Tamai ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Ischemia Reperfusion ◽  
Microvascular Dysfunction ◽  
Japanese Herbal Medicine

scholarly journals Proliferative effect of Hachimijiogan, a Japanese herbal medicine, in C2C12 skeletal muscle cells

Maturitas ◽  
2015 ◽  
Vol 81 (1) ◽  
pp. 231
Author(s):  
Takashi Takeda ◽  
Kenji Tsuiji ◽  
Bin Li ◽  
Mari Tadakawa ◽  
Masami Shiina ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Herbal Medicine ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Proliferative Effect ◽  
Japanese Herbal Medicine ◽  
C2c12 Skeletal Muscle Cells

scholarly journals Sinomenine attenuates airway inflammation and remodeling in a mouse model of asthma

2016 ◽  
Vol 13 (3) ◽  
pp. 2415-2422 ◽  
Author(s):  
HAI-RONG BAO ◽  
XIAO-JU LIU ◽  
YUN-LIN LI ◽  
XIANG MEN ◽  
XIAO-LI ZENG
Keyword(s):  
Mouse Model ◽  
Airway Inflammation
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