scholarly journals Testosterone reactivity to infant crying and caregiving in women: The role of oral contraceptives and basal cortisol

2019 ◽  
Vol 56 ◽  
pp. 101191 ◽  
Author(s):  
A. Voorthuis ◽  
M.J. Bakermans-Kranenburg ◽  
M.H. van IJzendoorn
1991 ◽  
Vol 20 (2) ◽  
pp. 121-135 ◽  
Author(s):  
John Bancroft ◽  
Barbara B. Sherwin ◽  
Gerianne M. Alexander ◽  
David W. Davidson ◽  
Anne Walker

1998 ◽  
Vol 275 (2) ◽  
pp. R357-R362 ◽  
Author(s):  
Kirsten R. Poore ◽  
I. Ross Young ◽  
Benedict J. Canny ◽  
Geoffrey D. Thorburn

Maturation of the fetal adrenal gland is critical for the onset of ovine parturition. It has long been proposed that the fetal adrenal gland may be under inhibitory influences during late gestation. In vitro evidence has suggested that angiotensin II may be such an inhibitory factor and may help to prevent a premature increase in cortisol concentrations. The aim of this study was to test the effect of angiotensin II infusion in vivo on basal cortisol concentrations and fetal adrenal responsiveness to an ACTH-(1—24) challenge. Fetuses received a continuous infusion of either angiotensin II (100 ng ⋅ min−1 ⋅ kg−1; n = 7) or saline (2 ml/h; n = 4), which commenced at 140 days of gestation (GA) and continued for a total of 50 h. Adrenal responsiveness to the administration of ACTH-(1—24) (5 μg/kg) was determined during angiotensin II or saline infusions at both 2 and 48 h after infusion onset. Angiotensin II had no significant effect on adrenal responsiveness after acute (2 h) or chronic (48 h) infusion. There was no effect of saline or angiotensin II infusion on basal immunoreactive ACTH or cortisol concentrations after 2 h, but there was a significant increase in basal cortisol concentrations in both treatment groups by 48 h, probably reflecting the normal rise in cortisol concentrations at this GA. Mean arterial blood pressure was significantly increased in angiotensin II-infused fetuses only. This study has therefore found no evidence to suggest that angiotensin II infusion in vivo modulates fetal basal cortisol concentrations or adrenal responsiveness in the last week of gestation, in contrast with previous in vitro studies. These results throw into question the proposed role of angiotensin II as a negative modulator of adrenal function in the ovine fetus.


1980 ◽  
Vol 111 (6) ◽  
pp. 655-674 ◽  
Author(s):  
DEAN E. KRUEGER ◽  
SUSAN S. ELLENBERG ◽  
SHERMAN BLOOM ◽  
BEVERLY M. CALKINS ◽  
CAROL MALIZA ◽  
...  

Cancers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1766 ◽  
Author(s):  
Atanas Ignatov ◽  
Olaf Ortmann

Endometrial cancer is the most common gynecologic cancer and is predominantly endocrine-related. The role of unopposed estrogen in the development of endometrial cancer has been investigated in numerous studies. Different reproductive factors such as younger age at menarche, late age at menopause, infertility, nulliparity, age of birth of the first child, and long-term use of unopposed estrogens during hormone replacement therapy have been associated with an increased risk of endometrial cancer. In contrast, there is a growing body of evidence for a protective role of oral contraceptives. Most of the published data on the association between infertility and polycystic ovary syndrome are inconclusive, whereas the effect of tamoxifen on the risk of endometrial cancer has been well established. With this review, we aim to summarize the evidence on the association between infertility, polycystic ovary syndrome, oral contraceptives, and tamoxifen and the development of endometrial cancer.


2015 ◽  
Vol 56 (5) ◽  
pp. 489-495 ◽  
Author(s):  
Anna Roos E. Zandstra ◽  
Johan Ormel ◽  
Esther Nederhof ◽  
Pieter J. Hoekstra ◽  
Catharina A. Hartman

2014 ◽  
Vol 21 (1) ◽  
pp. 10-19 ◽  
Author(s):  
Eduardo Fernández-Martínez ◽  
Elvia Pérez-Soto ◽  
Carlos González-Hernández ◽  
Mario I. Ortiz ◽  
Víctor Pérez-Álvarez ◽  
...  

2008 ◽  
Vol 29 (S1) ◽  
pp. 12-14 ◽  
Author(s):  
Gianni Allais ◽  
Ilaria Castagnoli Gabellari ◽  
Ornella Mana ◽  
Paola Schiapparelli ◽  
Maria Grazia Terzi ◽  
...  
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