Aggravated hepatotoxicity occurs in aged mice but not in young mice after oral exposure to zinc oxide nanoparticles

NanoImpact ◽  
2016 ◽  
Vol 3-4 ◽  
pp. 1-11 ◽  
Author(s):  
Yongyi Wei ◽  
Yang Li ◽  
Jianbo Jia ◽  
Yiguo Jiang ◽  
Bin Zhao ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Oral Exposure ◽  
Oxide Nanoparticles ◽  
Aged Mice ◽  
Young Mice

scholarly journals Optical imaging to trace near infrared fluorescent zinc oxide nanoparticles following oral exposure

2012 ◽  
pp. 3203 ◽  
Author(s):  
Seok Tae Lim ◽  
Hwan jeong Jeong ◽  
Dong Wook Kim ◽  
Seok Tae Lim ◽  
Myung Hee Sohn ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Optical Imaging ◽  
Zinc Oxide Nanoparticles ◽  
Near Infrared ◽  
Oral Exposure ◽  
Oxide Nanoparticles

Broiler welfare is preserved by long-term low-dose oral exposure to zinc oxide nanoparticles: preliminary study

2021 ◽  
pp. 1-16
Author(s):  
Manal A. M. Mahmoud ◽  
Doha Yahia ◽  
Doaa S. Abdel-Magiud ◽  
Madeha H. A. Darwish ◽  
Mahmoud Abd-Elkareem ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Low Dose ◽  
Oral Exposure ◽  
Oxide Nanoparticles ◽  
Dose Oral ◽  
Preliminary Study

scholarly journals Cellular Uptake and Toxicological Effects of Differently Sized Zinc Oxide Nanoparticles in Intestinal Cells

Toxics ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 96
Author(s):  
Anna Mittag ◽  
Christian Hoera ◽  
Alexander Kämpfe ◽  
Martin Westermann ◽  
Jochen Kuckelkorn ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Cell Lines ◽  
Cellular Uptake ◽  
Zinc Oxide Nanoparticles ◽  
Food Packaging ◽  
Food Additives ◽  
Intestinal Cell ◽  
Oral Exposure ◽  
Oxide Nanoparticles ◽  
Toxicological Effects

Due to their beneficial properties, the use of zinc oxide nanoparticles (ZnO NP) is constantly increasing, especially in consumer-related areas, such as food packaging and food additives, which is leading to an increased oral uptake of ZnO NP. Consequently, the aim of our study was to investigate the cellular uptake of two differently sized ZnO NP (<50 nm and <100 nm; 12–1229 µmol/L) using two human intestinal cell lines (Caco-2 and LT97) and to examine the possible resulting toxic effects. ZnO NP (<50 nm and <100 nm) were internalized by both cell lines and led to intracellular changes. Both ZnO NP caused time- and dose-dependent cytotoxic effects, especially at concentrations of 614 µmol/L and 1229 µmol/L, which was associated with an increased rate of apoptotic and dead cells. ZnO NP < 100 nm altered the cell cycle of LT97 cells but not that of Caco-2 cells. ZnO NP < 50 nm led to the formation of micronuclei in LT97 cells. The Ames test revealed no mutagenicity for both ZnO NP. Our results indicate the potential toxicity of ZnO NP after oral exposure, which should be considered before application.

scholarly journals Crosstalk of gut microbiota and serum/hippocampus metabolites in neurobehavioral impairments induced by oral zinc oxide nanoparticles exposure

2020 ◽  
Author(s):  
jianjun Chen ◽  
Shanshan Zhang ◽  
Chang Chen ◽  
Xuejun Jiang ◽  
Jingfu Qiu ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Gut Microbiota ◽  
Gut Microbiome ◽  
Zinc Oxide Nanoparticles ◽  
Oral Exposure ◽  
Oxide Nanoparticles ◽  
Rrna Gene ◽  
Environmental Toxicants ◽  
Microbial Composition ◽  
Α Diversity

Abstract Background Gut microbiome can be readily influenced by external factors, such as diet, antibiotic, bacterial/viral infection and environmental toxicants. Gut microbiota-mediated effects of engineered nanomaterials as such become the new frontiers in nanotoxicology. Methods An integrated approach combining 16S rRNA gene sequencing and liquid chromatography-mass spectrometry (LC-MS) metabolomics was used to determine the potential mechanistic pathway by which disturbed gut microbiota induced by ZnONPs might modulate host physiology and neurobehavior. Results Herein, we showed oral exposure to zinc oxide nanoparticles (ZnONPs), one typical kinds of nanomaterials used widely in the food industry, could cause the neurobehavioral dysfunctions in mice, manifested by spatial learning and memory deficits and locomotor activity inhibition. Our mechanistic results elucidated that ZnONPs exposure led to a marked disturbance of gut microbial composition but did not alter the microbiome α-diversity indexes. We also provided new evidence that neurobehavioral impairments induced by ZnONPs was closely associated with perturbation in the gut microbiota composition that were both specific to changes of neurobehavior-related genes (such as Bdnf and Dlg4 ) and correlated with serum and hippocampal metabolic disorders. Our data further identified a unique metabolite [DG(15:0/0:0/22:4n6)] that linked the relationships among gut microbiota, metabolites and neurobehavior-related genes. Conclusions ZnONPs exposure not only alters the gut microbiome community but also substantially disturbs its metabolic profiles, and therefore leading to neurobehavioral impairments vi gut-brain axis. These findings will provide a novel view for understanding the ZnONPs neurotoxicity through gut-brain axis and may lead to new potential prevention and treatment strategies.

Gut-brain communication in hyperfunction of 5-hydroxytryptamine induced by oral zinc oxide nanoparticles exposure in young mice

2020 ◽  
Vol 135 ◽  
pp. 110906 ◽  
Author(s):  
Shanshan Zhang ◽  
Shuqun Cheng ◽  
Xuejun Jiang ◽  
Jun Zhang ◽  
Lulu Bai ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Young Mice

Optical Characteristics of Zinc Oxide Nanoparticles with Surface Modification Using Polyethylene Glycol

2014 ◽  
Vol 29 (10) ◽  
pp. 1039
Author(s):  
TAN Man-Lin ◽  
WANG Yan-Tao ◽  
ZHANG Wei-Li ◽  
FU Dong-Ju ◽  
LI Dong-Shuang ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Surface Modification ◽  
Polyethylene Glycol ◽  
Zinc Oxide Nanoparticles ◽  
Optical Characteristics ◽  
Oxide Nanoparticles
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