scholarly journals Poor Repair of Skeletal Muscle in Aging Mice Reflects a Defect in Local, Interleukin-33-Dependent Accumulation of Regulatory T Cells

Immunity ◽  
2016 ◽  
Vol 44 (2) ◽  
pp. 355-367 ◽  
Author(s):  
Wilson Kuswanto ◽  
Dalia Burzyn ◽  
Marisella Panduro ◽  
Kathy K. Wang ◽  
Young Charles Jang ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
T Cells ◽  
Regulatory T Cells ◽  
Interleukin 33

scholarly journals Regulatory T cells and skeletal muscle regeneration

FEBS Journal ◽  
2016 ◽  
Vol 284 (4) ◽  
pp. 517-524 ◽  
Author(s):  
Stefano Schiaffino ◽  
Marcelo G. Pereira ◽  
Stefano Ciciliot ◽  
Patrizia Rovere-Querini
Keyword(s):  
Skeletal Muscle ◽  
T Cells ◽  
Regulatory T Cells ◽  
Muscle Regeneration ◽  
Skeletal Muscle Regeneration

scholarly journals Interleukin-33 activates regulatory T cells to suppress innate γδ T cell responses in the lung

2020 ◽  
Vol 21 (11) ◽  
pp. 1371-1383
Author(s):  
Lucas D. Faustino ◽  
Jason W. Griffith ◽  
Rod A. Rahimi ◽  
Keshav Nepal ◽  
Daniel L. Hamilos ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Regulatory T Cells ◽  
T Cell Responses ◽  
Γδ T Cell ◽  
Interleukin 33 ◽  
Cell Responses

Interleukin-33 pretreatment promotes metastatic growth of murine melanoma by reducing the cytotoxic capacity of CD8+ T cells and enhancing regulatory T cells

2020 ◽  
Vol 69 (8) ◽  
pp. 1461-1475 ◽  
Author(s):  
Andra Jevtovic ◽  
Jelena Pantic ◽  
Ivan Jovanovic ◽  
Marija Milovanovic ◽  
Ivan Stanojevic ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Cd8 T Cells ◽  
Interleukin 33 ◽  
Murine Melanoma ◽  
Metastatic Growth

1.64 Interleukin-33 suppresses experimental arthritis through promoting Foxp3+regulatory T-cells and type-2 immune responses in mice

2014 ◽  
Vol 73 (Suppl 1) ◽  
pp. A28.1-A28 ◽  
Author(s):  
Jérôme Biton ◽  
Allan Thiolat ◽  
Sara Khaleghparast Athari ◽  
Delphine Lemeiter ◽  
Roxane Hervé ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Immune Responses ◽  
Experimental Arthritis ◽  
Interleukin 33

scholarly journals Regulatory T Cells Exhibit Interleukin-33-Dependent Migratory Behavior during Skin Barrier Disruption

2021 ◽  
Vol 22 (14) ◽  
pp. 7443
Author(s):  
Sumika Toyama ◽  
Catharina Sagita Moniaga ◽  
Susumu Nakae ◽  
Masaru Kurosawa ◽  
Hideoki Ogawa ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Transforming Growth Factor ◽  
Sodium Dodecyl ◽  
Skin Barrier ◽  
Neutralizing Antibody ◽  
Interleukin 33 ◽  
Barrier Disruption ◽  
Inflammatory Conditions ◽  
Skin Infiltration

Regulatory T cells (Tregs) suppress immune responses and maintain immunological self-tolerance and homeostasis. We currently investigated relationships between skin barrier condition and Treg behavior using skin barrier-disrupted mice. Skin barrier disruption was induced by repeated topical application of 4% sodium dodecyl sulfate (SDS) on mice. The number of CD4+ forkhead box protein P3 (Foxp3)+ Tregs was higher in 4% SDS-treated skins than in controls. This increasing was correlated with the degree of acanthosis. The numbers of interleukin (IL)-10+ and transforming growth factor (TGF)-β+ Tregs also increased in 4% SDS-treated skins. Localization of IL-33 in keratinocytes shifted from nucleus to cytoplasm after skin barrier disruption. Notably, IL-33 promoted the migration of Tregs in chemotaxis assay. The skin infiltration of Tregs was cancelled in IL-33 neutralizing antibody-treated mice and IL-33 knockout mice. Thus, keratinocyte-derived IL-33 may induce Treg migration into barrier-disrupted skin to control the phase transition between healthy and inflammatory conditions.

Interleukin 33 ameliorates disturbance of regulatory T cells in pulmonary sarcoidosis

2018 ◽  
Vol 64 ◽  
pp. 208-216 ◽  
Author(s):  
Bin Zhang ◽  
Fan Zhao ◽  
Huimin Mao ◽  
Wenyan Ma ◽  
Yang Zhang ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Pulmonary Sarcoidosis ◽  
Interleukin 33

Abstract A50: Interleukin-33 increases ST2+ regulatory T cells and promotes metastatic tumor growth in the lungs in an amphiregulin-dependent manner

2020 ◽  
Author(s):  
Elizabeth C. Halvorsen ◽  
S. Elizabeth Franks ◽  
Brennan J. Wadsworth ◽  
Bryant T. Harbourne ◽  
Rachel A. Cederberg ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Tumor Growth ◽  
Metastatic Tumor ◽  
Dependent Manner ◽  
Interleukin 33

scholarly journals Longitudinal single cell profiling of regulatory T cells identifies IL-33 as a driver of tumor immunosuppression

2019 ◽  
Author(s):  
Amy Li ◽  
Rebecca H. Herbst ◽  
David Canner ◽  
Jason M. Schenkel ◽  
Olivia C. Smith ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Single Cell ◽  
Critical Role ◽  
Tumor Development ◽  
Tumor Burden ◽  
Multiple Cancer ◽  
Interleukin 33 ◽  
Genetic Mouse Model ◽  
Enhanced Expression

ABSTRACTRegulatory T cells (Tregs) can impair anti-tumor immune responses and are associated with poor prognosis in multiple cancer types. Tregs in human tumors span diverse transcriptional states distinct from those of peripheral Tregs, but their contribution to tumor development remains unknown. Here, we used single cell RNA-Seq to longitudinally profile conventional CD4+ T cells (Tconv) and Tregs in a genetic mouse model of lung adenocarcinoma. Tissue-infiltrating and peripheral CD4+ T cells differed, highlighting divergent pathways of activation during tumorigenesis. Longitudinal shifts in Treg heterogeneity suggested increased terminal differentiation and stabilization of an effector phenotype over time. In particular, effector Tregs had enhanced expression of the interleukin 33 receptor ST2. Treg-specific deletion of ST2 reduced effector Tregs, increased infiltration of CD8+ T cells into tumors, and decreased tumor burden. Our study shows that ST2 plays a critical role in Treg-mediated immunosuppression in cancer, highlighting new potential paths for therapeutic intervention.

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