scholarly journals Skin-Resident Murine Dendritic Cell Subsets Promote Distinct and Opposing Antigen-Specific T Helper Cell Responses

Immunity ◽  
2011 ◽  
Vol 35 (2) ◽  
pp. 260-272 ◽  
Author(s):  
Botond Z. Igyártó ◽  
Krystal Haley ◽  
Daniela Ortner ◽  
Aleh Bobr ◽  
Maryam Gerami-Nejad ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
T Helper Cell ◽  
Helper Cell ◽  
T Helper ◽  
Cell Responses ◽  
Dendritic Cell Subsets

scholarly journals Candida albicans Morphology and Dendritic Cell Subsets Determine T Helper Cell Differentiation

Immunity ◽  
2015 ◽  
Vol 42 (2) ◽  
pp. 356-366 ◽  
Author(s):  
Sakeen W. Kashem ◽  
Botond Z. Igyártó ◽  
Maryam Gerami-Nejad ◽  
Yosuke Kumamoto ◽  
Javed Mohammed ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Cell Differentiation ◽  
Dendritic Cell ◽  
T Helper Cell ◽  
Helper Cell ◽  
T Helper ◽  
Dendritic Cell Subsets

scholarly journals The ability of murine dendritic cell subsets to direct T helper cell differentiation is dependent on microbial signals

2003 ◽  
Vol 33 (1) ◽  
pp. 101-107 ◽  
Author(s):  
Shivanthi P. Manickasingham ◽  
Alexander D. Edwards ◽  
Oliver Schulz ◽  
Caetano Reis e Sousa
Keyword(s):  
Cell Differentiation ◽  
Dendritic Cell ◽  
T Helper Cell ◽  
Helper Cell ◽  
T Helper ◽  
Dendritic Cell Subsets

Augmentation of HIV-1-specific T helper cell responses in chronic HIV-1 infection by therapeutic immunization

AIDS ◽  
2003 ◽  
Vol 17 (8) ◽  
pp. 1121-1126 ◽  
Author(s):  
Gregory K Robbins ◽  
Marylyn M Addo ◽  
Hien Troung ◽  
Almas Rathod ◽  
Kathy Habeeb ◽  
...  
Keyword(s):  
T Helper Cell ◽  
Helper Cell ◽  
T Helper ◽  
Cell Responses ◽  
Hiv 1

scholarly journals Tetanus Toxoid carrier protein induced T-helper cell responses upon vaccination of middle-aged adults

Vaccine ◽  
2017 ◽  
Vol 35 (42) ◽  
pp. 5581-5588 ◽  
Author(s):  
Marieke van der Heiden ◽  
Aafke Duizendstra ◽  
Guy A.M. Berbers ◽  
Annemieke M.H. Boots ◽  
Anne-Marie Buisman
Keyword(s):  
Tetanus Toxoid ◽  
T Helper Cell ◽  
Helper Cell ◽  
Carrier Protein ◽  
T Helper ◽  
Middle Aged ◽  
Cell Responses ◽  
Middle Aged Adults

scholarly journals Regulation of T Cell Responses by Ionic Salt Signals

Cells ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 2365
Author(s):  
Christina E. Zielinski
Keyword(s):  
T Cells ◽  
T Cell ◽  
Sodium Chloride ◽  
T Cell Responses ◽  
T Helper Cell ◽  
Helper Cell ◽  
T Helper ◽  
Tissue Microenvironment ◽  
Cell Responses ◽  
The Impact

T helper cell responses are tailored to their respective antigens and adapted to their specific tissue microenvironment. While a great proportion of T cells acquire a resident identity, a significant proportion of T cells continue circulating, thus encountering changing microenvironmental signals during immune surveillance. One signal, which has previously been largely overlooked, is sodium chloride. It has been proposed to have potent effects on T cell responses in the context of autoimmune, allergic and infectious tissue inflammation in mouse models and humans. Sodium chloride is stringently regulated in the blood by the kidneys but displays differential deposition patterns in peripheral tissues. Sodium chloride accumulation might furthermore be regulated by dietary intake and thus by intentional behavior. Together, these results make sodium chloride an interesting but still controversial signal for immune modulation. Its downstream cellular activities represent a potential therapeutic target given its effects on T cell cytokine production. In this review article, we provide an overview and critical evaluation of the impact of this ionic signal on T helper cell polarization and T helper cell effector functions. In addition, the impact of sodium chloride from the tissue microenvironment is assessed for human health and disease and for its therapeutic potential.

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