scholarly journals Dendritic Cells Rapidly Recruited into Epithelial Tissues via CCR6/CCL20 Are Responsible for CD8+ T Cell Crosspriming In Vivo

Immunity ◽  
2006 ◽  
Vol 24 (2) ◽  
pp. 191-201 ◽  
Author(s):  
Marie Le Borgne ◽  
Nathalie Etchart ◽  
Anne Goubier ◽  
Sergio A. Lira ◽  
Jean Claude Sirard ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Cd8 T Cell ◽  
Epithelial Tissues

scholarly journals Plasmacytoid Dendritic Cells Take Up Opsonized Antigen Leading to CD4+and CD8+T Cell Activation In Vivo

2008 ◽  
Vol 181 (6) ◽  
pp. 3811-3817 ◽  
Author(s):  
Pia Björck ◽  
Andreas Beilhack ◽  
Edward I. Herman ◽  
Robert S. Negrin ◽  
Edgar G. Engleman
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Cd8 T Cell ◽  
Plasmacytoid Dendritic Cells

scholarly journals Plasmacytoid dendritic cells efficiently cross-prime naive T cells in vivo after TLR activation

Blood ◽  
2008 ◽  
Vol 112 (9) ◽  
pp. 3713-3722 ◽  
Author(s):  
Juliette Mouriès ◽  
Gabriel Moron ◽  
Géraldine Schlecht ◽  
Nicolas Escriou ◽  
Gilles Dadaglio ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Antigen Processing ◽  
Cytotoxic T Lymphocyte ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Cross Presentation ◽  
Cell Responses

Abstract Cross-presentation is a crucial mechanism in tumoral and microbial immunity because it allows internalized cell associated or exogenous antigens (Ags) to be delivered into the major histocompatibility complex I pathway. This pathway is important for the development of CD8+ T-cell responses and for the induction of tolerance. In mice, cross-presentation is considered to be a unique property of CD8α+ conventional dendritic cells (DCs). Here we show that splenic plasmacytoid DCs (pDCs) efficiently capture exogenous Ags in vivo but are not able to cross-present these Ags at steady state. However, in vitro and in vivo stimulation by Toll-like receptor-7, or -9 or viruses licenses pDCs to cross-present soluble or particulate Ags by a transporter associated with antigen processing-dependent mechanism. Induction of cross-presentation confers to pDCs the ability to generate efficient effector CD8+ T-cell responses against exogenous Ags in vivo, showing that pDCs may play a crucial role in induction of adaptive immune responses against pathogens that do not infect tissues of hemopoietic origin. This study provides the first evidence for an in vivo role of splenic pDCs in Ag cross-presentation and T-cell cross-priming and suggests that pDCs may constitute an attractive target to boost the efficacy of vaccines based on cytotoxic T lymphocyte induction.

scholarly journals Dendritic Cells Prime In Vivo Alloreactive CD4 T Lymphocytes Toward Type 2 Cytokine- and TGF-β-Producing Cells in the Absence of CD8 T Cell Activation

2000 ◽  
Vol 165 (9) ◽  
pp. 4994-5003 ◽  
Author(s):  
Gilles Foucras ◽  
Jérôme D. Coudert ◽  
Christiane Coureau ◽  
Jean-Charles Guéry
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
T Lymphocytes ◽  
T Cell Activation ◽  
Cell Activation ◽  
Cd8 T Cell

scholarly journals XCR1+ dendritic cells promote memory CD8+ T cell recall upon secondary infections with Listeria monocytogenes or certain viruses

2015 ◽  
Vol 213 (1) ◽  
pp. 75-92 ◽  
Author(s):  
Yannick O. Alexandre ◽  
Sonia Ghilas ◽  
Cindy Sanchez ◽  
Agnès Le Bon ◽  
Karine Crozat ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Listeria Monocytogenes ◽  
T Cell ◽  
Nk Cells ◽  
Nk Cell ◽  
Infectious Agent ◽  
Cd8 T Cell ◽  
Dependent Manner ◽  
Secondary Infections

Naive CD8+ T cell priming during tumor development or many primary infections requires cross-presentation by XCR1+ dendritic cells (DCs). Memory CD8+ T lymphocytes (mCTLs) harbor a lower activation threshold as compared with naive cells. However, whether their recall responses depend on XCR1+ DCs is unknown. By using a new mouse model allowing fluorescent tracking and conditional depletion of XCR1+ DCs, we demonstrate a differential requirement of these cells for mCTL recall during secondary infections by different pathogens. XCR1+ DCs were instrumental to promote this function upon secondary challenges with Listeria monocytogenes, vesicular stomatitis virus, or Vaccinia virus, but dispensable in the case of mouse cytomegalovirus. We deciphered how XCR1+ DCs promote mCTL recall upon secondary infections with Listeria. By visualizing for the first time the in vivo choreography of XCR1+ DCs, NK cells and mCTLs during secondary immune responses, and by neutralizing in vivo candidate molecules, we demonstrate that, very early after infection, mCTLs are activated, and attracted in a CXCR3-dependent manner, by NK cell–boosted, IL-12–, and CXCL9-producing XCR1+ DCs. Hence, depending on the infectious agent, strong recall of mCTLs during secondary challenges can require cytokine- and chemokine-dependent cross-talk with XCR1+ DCs and NK cells.

Bordetella pertussis adenylate cyclase delivers chemically coupled CD8+ T-cell epitopes to dendritic cells and elicits CTL in vivo

Vaccine ◽  
2004 ◽  
Vol 23 (5) ◽  
pp. 604-614 ◽  
Author(s):  
Catherine Fayolle ◽  
Cécile Bauche ◽  
Daniel Ladant ◽  
Claude Leclerc
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Adenylate Cyclase ◽  
Bordetella Pertussis ◽  
Cd8 T Cell ◽  
T Cell Epitopes

scholarly journals Induction of Potent CD8 T Cell Cytotoxicity by Specific Targeting of Antigen to Cross-Presenting Dendritic Cells In Vivo via Murine or Human XCR1

2014 ◽  
Vol 194 (3) ◽  
pp. 1069-1079 ◽  
Author(s):  
Evelyn Hartung ◽  
Martina Becker ◽  
Annabell Bachem ◽  
Nele Reeg ◽  
Anika Jäkel ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Cd8 T Cell ◽  
Cell Cytotoxicity ◽  
Specific Targeting ◽  
T Cell Cytotoxicity
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