Association of TCR/CD3, PTPN22, CD28 and ZAP70 gene polymorphisms with type 1 diabetes risk in Tunisian population: Family based association study

2015 ◽  
Vol 163 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Zouidi Ferjeni ◽  
D. Bouzid ◽  
H. Fourati ◽  
M. Stayoussef ◽  
O. Abida ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Association Study ◽  
Gene Polymorphisms ◽  
Diabetes Risk ◽  
Tunisian Population ◽  
Family Based

Association between the IL2RA polymorphism and type 1 diabetes risk: Family based association study

Meta Gene ◽  
2016 ◽  
Vol 10 ◽  
pp. 118-122 ◽  
Author(s):  
Zouidi Ferjani ◽  
D. Bouzid ◽  
H. Fourati ◽  
R. Fakhfakh ◽  
T. Kammoun ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Association Study ◽  
Diabetes Risk ◽  
Family Based

Family-based association study of HLA class II with type 1 diabetes in Moroccans

2015 ◽  
Vol 63 (2) ◽  
pp. 80-84 ◽  
Author(s):  
A. Drissi Bourhanbour ◽  
N. Benseffaj ◽  
S. Ouadghiri ◽  
R. Razine ◽  
A. Touzani ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Association Study ◽  
Class Ii ◽  
Hla Class Ii ◽  
Family Based

scholarly journals Family-based analysis of vitamin D receptor gene polymorphisms and type 1 diabetes in the population of South Croatia

2007 ◽  
Vol 53 (3) ◽  
pp. 210-214 ◽  
Author(s):  
Vesna Boraska ◽  
Veselin Škrabić ◽  
Eleftheria Zeggini ◽  
Christopher James Groves ◽  
Maja Buljubašić ◽  
...  
Keyword(s):  
Vitamin D ◽  
Type 1 Diabetes ◽  
Vitamin D Receptor ◽  
Gene Polymorphisms ◽  
Receptor Gene ◽  
Vitamin D Receptor Gene ◽  
Receptor Gene Polymorphisms ◽  
Family Based

scholarly journals Cesarean Section and Interferon-Induced Helicase Gene Polymorphisms Combine to Increase Childhood Type 1 Diabetes Risk

Diabetes ◽  
2011 ◽  
Vol 60 (12) ◽  
pp. 3300-3306 ◽  
Author(s):  
E. Bonifacio ◽  
K. Warncke ◽  
C. Winkler ◽  
M. Wallner ◽  
A.-G. Ziegler
Keyword(s):  
Type 1 Diabetes ◽  
Cesarean Section ◽  
Gene Polymorphisms ◽  
Diabetes Risk ◽  
Helicase Gene ◽  
Childhood Type 1 Diabetes ◽  
Childhood Type

scholarly journals Association Study of Human MTH1 Gene Polymorphisms with Type 1 Diabetes Mellitus

2004 ◽  
Vol 51 (5) ◽  
pp. 493-498 ◽  
Author(s):  
Kenichi MIYAKO ◽  
Hitoshi KOHNO ◽  
Kenji IHARA ◽  
Ryuichi KUROMARU ◽  
Nobuo MATSUURA ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Association Study ◽  
Gene Polymorphisms

scholarly journals Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci

2008 ◽  
Vol 40 (12) ◽  
pp. 1399-1401 ◽  
Author(s):  
Jason D Cooper ◽  
Deborah J Smyth ◽  
Adam M Smiles ◽  
Vincent Plagnol ◽  
Neil M Walker ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Meta Analysis ◽  
Study Data ◽  
Diabetes Risk ◽  
Genome Wide Association ◽  
Genome Wide

scholarly journals Estimation of Diabetes Risk in Brazilian Population by Typing for Polymorphisms in HLA-DR-DQ, INS and CTLA-4 Genes

2005 ◽  
Vol 21 (3) ◽  
pp. 139-145 ◽  
Author(s):  
Omar M. Hauache ◽  
André F. Reis ◽  
Carolina S.V. Oliveira ◽  
José Gilberto H. Vieira ◽  
Minna Sjüroos ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 1 Diabetes ◽  
Gene Polymorphisms ◽  
Diabetes Risk ◽  
Brazilian Population ◽  
Healthy Controls ◽  
Typing Method ◽  
Hla Dr ◽  
Screening Sensitivity

The study aimed to further characterise HLA encoded risk factors of type 1 diabetes (T1D) in Brazilian population and test the capability of a low resolution full-house DR-DQ typing method to find subjects at diabetes risk. Insulin and CTLA-4 gene polymorphisms were also analysed. The method is based on an initial DQB1 typing supplemented by DQA1 and DR4 subtyping when informative. Increased frequencies of both (DR3)-DQA1*05-DQB1*02 and DRB1*04-DQA1*03-DQB1*0302 haplotypes were detected among patients. DRB1*0401, *0402, *0404 and *0405 alleles were all common in DQB1*0302 haplotypes and associated with T1D. (DRB1*11/12/1303)-DQA1*05-DQB1*0301, (DRB1*01/10)-DQB1*0501, (DRB1*15)-DQB1*0602 and (DRB1*1301)-*0603 haplotypes were significantly decreased among patients. Genotypes with two risk haplotypes or a combination of a susceptibility associated and a neutral haplotype were found in 78 of 126 (61.9%) T1D patients compared to 8 of 75 (10.7%) control subjects (P< 0.0001). Insulin gene −2221 C/T polymorphism was also associated with diabetes risk: CC genotype was found among 83.1% of patients compared to 69.3% of healthy controls (P= 0.0369, OR 1.98) but CTLA-4 gene +49 A/G polymorphism did not significantly differ between patients and controls. Despite the diversity of the Brazilian population the screening sensitivity and specificity of the used method for T1D risk was similar to that obtained in Europe.

Immunization profiles and progression of islet autoimmunity in children at type 1 diabetes risk

2012 ◽  
Vol 7 (S 01) ◽  
Author(s):  
R Chmiel ◽  
S Krause ◽  
A Knopff ◽  
C Matzke ◽  
D Höfelmann ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Diabetes Risk ◽  
Islet Autoimmunity
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