Anti-inflammatory action of alpha-melanocyte stimulating hormone (α-MSH) in anti-CD3/CD28-mediated spleen and CD4+CD25− T cells and a partial participation of IL-10

2008 ◽  
Vol 118 (1) ◽  
pp. 44-48 ◽  
Author(s):  
Sung Ho Chang ◽  
Eun Jung Jung ◽  
Dong Gyun Lim ◽  
Youn Hee Park ◽  
Yu Mee Wee ◽  
...  
Keyword(s):  
T Cells ◽  
Melanocyte Stimulating Hormone ◽  
Anti Inflammatory ◽  
Inflammatory Action ◽  
Stimulating Hormone

Anti-Inflammatory Effects of α-Melanocyte-Stimulating Hormone in Celiac Intestinal Mucosa

2002 ◽  
Vol 10 (4) ◽  
pp. 208-216 ◽  
Author(s):  
Gualtiero Colombo ◽  
Roberto Buffa ◽  
Maria Teresa Bardella ◽  
Letizia Garofalo ◽  
Andrea Carlin ◽  
...  
Keyword(s):  
Intestinal Mucosa ◽  
Melanocyte Stimulating Hormone ◽  
Anti Inflammatory ◽  
Stimulating Hormone

scholarly journals The Alpha-Melanocyte Stimulating Hormone Induces Conversion of Effector T Cells into Treg Cells

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Andrew W. Taylor ◽  
Darren J. Lee
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cell Population ◽  
Treg Cells ◽  
Effector T Cells ◽  
Regulatory Activity ◽  
Effector T Cell ◽  
Melanocyte Stimulating Hormone ◽  
Specific Antigens ◽  
Stimulating Hormone

The neuropeptide alpha-melanocyte stimulating hormone (α-MSH) has an important role in modulating immunity and homeostasis. The production of IFN-γby effector T cells is suppressed byα-MSH, while TGF-βproduction is promoted in the same cells. Suchα-MSH-treated T cells have immune regulatory activity and suppress hypersensitivity, autoimmune diseases, and graft rejection. Previous characterizations of theα-MSH-induced Treg cells showed that the cells areCD4+T cells expressing the same levels of CD25 as effector T cells. Therefore, we further analyzed theα-MSH-induced Treg cells for expression of effector and regulatory T-cell markers. Also, we examined the potential forα-MSH-induced Treg cells to be from the effector T-cell population. We found that theα-MSH-induced Treg cells areCD25+  CD4+T cells that share similar surface markers as effector T cells, except that they express on their surface LAP. Also, theα-MSH treatment augments FoxP3 message in the effector T cells, andα-MSH induction of regulatory activity was limited to the effectorCD25+T-cell population. Therefore,α-MSH converts effector T cells into Treg cells, which suppress immunity targeting specific antigens and tissues.

[d-Trp8]-γ-Melanocyte-Stimulating Hormone Exhibits Anti-Inflammatory Efficacy in Mice Bearing a Nonfunctional MC1R (Recessive Yellow e/e Mouse)

2006 ◽  
Vol 70 (6) ◽  
pp. 1850-1855 ◽  
Author(s):  
Stephen J. Getting ◽  
Connie W. Lam ◽  
Giovanna Leoni ◽  
Felicity N. E. Gavins ◽  
Paolo Grieco ◽  
...  
Keyword(s):  
Melanocyte Stimulating Hormone ◽  
Anti Inflammatory ◽  
Stimulating Hormone

scholarly journals Alpha-Melanocyte Stimulating Hormone: An Emerging Anti-Inflammatory Antimicrobial Peptide

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Madhuri Singh ◽  
Kasturi Mukhopadhyay
Keyword(s):  
Antimicrobial Activity ◽  
Antimicrobial Peptides ◽  
Antimicrobial Peptide ◽  
Bacterial Pathogens ◽  
Melanocyte Stimulating Hormone ◽  
Antimicrobial Potential ◽  
Anti Inflammatory ◽  
Infective Agent ◽  
Stimulating Hormone

The alpha-melanocyte stimulating hormone (α-MSH) is a neuropeptide belonging to the melanocortin family. It is well known for its anti-inflammatory and antipyretic effects and shares several characteristics with antimicrobial peptides (AMPs). There have been some recent reports about the direct antimicrobial activity ofα-MSH against various microbes belonging to both fungal and bacterial pathogens. Similar toα-MSH’s anti-inflammatory properties, its C-terminal residues also exhibit antimicrobial activity parallel to that of the entire peptide. This review is focused on the current findings regarding the direct antimicrobial potential and immunomodulatory mechanism ofα-MSH and its C-terminal fragments, with particular emphasis on the prospects ofα-MSH based peptides as a strong anti-infective agent.

Sign in / Sign up

Export Citation Format

Share Document