Conditional haploinsufficiency of NCF1 (encoding p47phox), a signaling gene with a heterozygous phenotype potentially subject to natural selection

2005 ◽  
Vol 97 (1) ◽  
pp. 63-67 ◽  
Author(s):  
N.A. Mitchison ◽  
M. Harbord ◽  
A. Hankin ◽  
J. Roes
Keyword(s):  
Natural Selection ◽  
Heterozygous Phenotype

Natural selection and "sudden death."

1979 ◽  
Vol 34 (3) ◽  
pp. 274-275
Author(s):  
David Chiszar ◽  
Karlana Carpen
Keyword(s):  
Natural Selection ◽  
Sudden Death

The Natural Selection of Minds

1998 ◽  
Vol 43 (4) ◽  
pp. 263-264
Author(s):  
Joseph F. Rychlak
Keyword(s):  
Natural Selection ◽  
Selection Of

The Evolution of Lead Extraction

2009 ◽  
Vol 5 (1) ◽  
pp. 32
Author(s):  
Melanie Maytin ◽  
Laurence M Epstein ◽  
◽  
Keyword(s):  
Natural Selection ◽  
Lead Extraction ◽  
Significant Morbidity ◽  
Extraction Techniques ◽  
Extraction Technology ◽  
Device Management ◽  
Future Developments ◽  
The Past ◽  
New Methods ◽  
Life Threatening

Prior to the introduction of successful intravascular countertraction techniques, options for lead extraction were limited and dedicated tools were non-existent. The significant morbidity and mortality associated with these early extraction techniques limited their application to life-threatening situations such as infection and sepsis. The past 30 years have witnessed significant advances in lead extraction technology, resulting in safer and more efficacious techniques and tools. This evolution occurred out of necessity, similar to the pressure of natural selection weeding out the ineffective and highly morbid techniques while fostering the development of safe, successful and more simple methods. Future developments in lead extraction are likely to focus on new tools that will allow us to provide comprehensive device management and the design of new leads conceived to facilitate future extraction. With the development of these new methods and novel tools, the technique of lead extraction will continue to require operators that are well versed in several methods of extraction. Garnering new skills while remembering the lessons of the past will enable extraction technologies to advance without repeating previous mistakes.

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