Diabetes mellitus in adults: association of HLA DRB1 and DQB1 diabetes risk alleles with GADab presence and C-peptide secretion

2004 ◽  
Vol 95 (2) ◽  
pp. 229-232 ◽  
Author(s):  
Peter Novota ◽  
Marie Cerna ◽  
Katarina Kolostova ◽  
Pavlina Cejkova ◽  
Emanuel Zdarsky ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetes Risk ◽  
C Peptide ◽  
Risk Alleles ◽  
Peptide Secretion

scholarly journals Comparison of proinsulin and C-peptide secretion in healthy versus long-standing type 1 diabetes mellitus cohorts: A pilot study

PLoS ONE ◽  
2018 ◽  
Vol 13 (11) ◽  
pp. e0207065 ◽  
Author(s):  
Catherine A. Sullivan ◽  
Jose M. Cacicedo ◽  
Iniya Rajendran ◽  
Devin W. Steenkamp
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Pilot Study ◽  
Type 1 Diabetes Mellitus ◽  
C Peptide ◽  
Peptide Secretion

Lymphocyte transfusion in recent onset type I diabetes mellitus—A one-year follow-up of cell-mediated anti-islet cytotoxicity and C-peptide secretion

1990 ◽  
Vol 3 (5) ◽  
pp. 601-609 ◽  
Author(s):  
Jürgen Krug ◽  
Hans-Joachim Verlohren ◽  
Bernd Bierwolf ◽  
Eberhard Lampeter ◽  
Michael Borte ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type I Diabetes ◽  
Type I Diabetes Mellitus ◽  
Type I ◽  
C Peptide ◽  
Recent Onset ◽  
Onset Type ◽  
One Year ◽  
Peptide Secretion

Recovery from Decompensated Non-insulin-dependent Diabetes Mellitus: Studies of C-Peptide Secretion

Diabetes Care ◽  
1981 ◽  
Vol 4 (3) ◽  
pp. 354-359 ◽  
Author(s):  
M. Rendell ◽  
J. Zarriello ◽  
H. M. Drew ◽  
B. Dranbauer ◽  
G. Wilson ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
C Peptide ◽  
Insulin Dependent ◽  
Peptide Secretion

scholarly journals Clinical polymorphism of type 2 diabetes in children — the first study in Russia

2015 ◽  
Vol 61 (6) ◽  
pp. 10-16
Author(s):  
Irina Aleksandrovna Eremina ◽  
Tamara Leonidovna Kuraeva ◽  
Lubov Iosifovna Zilberman ◽  
Alexander Yur'evich Mayorov ◽  
Ekaterina Olegovna Koksharova
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
C Peptide ◽  
History Of ◽  
Peptide Secretion

Objective.To elucidate the specific features of diagnostics, clinical course and manifestations of type 2 diabetes mellitus (DM2) in the children of the Russian population.Material and methods.A total of 80 children presenting with DM2 were enrolled in the study including 70 available for the dynamic examination, with the follow-up period of 2.6 years (1.5; 4.5). The general clinical examination of the patients was supplemented by measuring insulin secretion, studying HLA-polymorphism of the DQ and DR-genes, and determination of type 1 diabetes (DM1) — related specific antibodies (At).Results.The median age at diagnosis of DM2 was 13 years (11.5; 15.5). 58.8% of the children had a family history of DM2 but only 26.3% of them had classical complaints of diabetes mellitus. In 65% of the children, DM2 was diagnosed when they were passing medical examination in connection with obesity (in 51.9% with the use the oral glucose tolerance test (OGTP); 48.1% of these children had the fasting blood glucose level above 7.0 mmol/l. Ketonuria at the onset of the disease was documented in 21.3% of the patients while 85% were either obese or overweight. Antibodies (ICA and IAA) were detected in 15.2% of the children at a low titer. The HLA-genotype associated with a high risk of development of DM1 was identified in 5.5% of the cases. The glycosylated hemoglobin test revealed its mean level of 7.1% (6.3; 8.5%) at the onset of diabetes; in the majority of the children, it fell down below 6.5% within the first 3 years of the disease. During this period, insulin and C-peptide secretion remained elevated. Insulin resistance was initially documented in 81.3% of the children; the dynamic observation failed to show its appreciable decrease. Insulin therapy initiated at the onset of the disease was prescribed to 30% of the patients. After 3 years, only 8% of the children retaining endogenous insulin secretion continued to use insulin.Conclusion.The asymptomatic onset of type 2 diabetes mellitus in the children and adolescents emphasizes the importance of its active diagnostics during the pubertal period in the high risk groups comprising the patients with obesity and the family history of DM2. In one third of the children, the diagnosis of DM2 was possible only with the use the oral glucose tolerance test. DM2 in the children and adolescents is characterized by clinical polymorphism in the form of acute manifestations in 21% of the cases and the absence of obesity and insulin resistance in 15 and 18% respectively. This finding suggests the necessity of differential diagnostics of such cases from DM1 and MODY. Rather high insulin and C-peptide secretion persists for 3 years after the onset of DM2 in the children. Therefore, they do not need insulin therapy during this period. The presence of ICA and IAA antibodies at low titers does not compromise diagnosis of DM2.

scholarly journals Long-term β-cells autoimmune destruction markers persistence and residual C-peptide secretion in type 1 diabetes mellitus

2021 ◽  
Vol 24 (5) ◽  
pp. 433-439
Author(s):  
M. R. Ragimov ◽  
O. S. Derevyanko ◽  
N. M. Malysheva ◽  
Z. T. Zuraeva ◽  
L. V. Nikankina ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Control Group ◽  
Acid Decarboxylase ◽  
Autoimmune Process ◽  
Β Cells ◽  
C Peptide ◽  
Group A ◽  
Peptide Secretion

Backgraund: It believed that autoimmune process maintained only during the first 5 years of diabetes mellitus type 1 (T1D). Recently scientists discovered the high levels of islet autoantibodies (Ab) in long-standing T1D and some of these patients had residual insulin secretion, determined by the level of C-peptide. According to various sources, the prevalence of such observations ranges from 12 to 48%.Aims: The aim of our study was to assess the duration of autoimmune β-cells destruction markers persistence and residual fasting C-peptide secretion in the long-standing T1D, as well as to determine the possible causes and patterns of these processes.Materials and methods: In the study included 237 patients (91 men, 146 women) with T1D. Patients divided in 4 groups, according to disease duration: а — up to 1 year, n=69 (29%); b — 1–5 years, 52 (22%); c — 5–10 years, 57 (24%); d — more than 10 years, 59 (25%). Ab to glutamic acid decarboxylase (GADA), tyrosine phosphatase-like IA-2 (IA2) and zinc T8 (ZnT8A) were detected by Enzyme Immunoassay. Also detected C-peptide levels and retrospectively HbA1с.Results: Antibodies to antigens of β-cell components were detected in 26 (37%) patients in group A, in 17 patients (33%) in group B, in 15 (29%) in group C and in 14 (23%) — G.In the control group (n = 19), an increased level of antibodies was not revealed. Fasting C-peptide levels were as follows: in group «A» — 0.86 ng / ml [0.53; 1.4], «B» — 0.65 ng / ml [0.27; 0.98], « B «- 0.19 ng / ml [0.17; 0.33],» D «- 0.01 ng / ml [0.01; 0.01]. However, in 13 (22%) patients in group D, fasting C-peptide levels were more than 0.09 ng / ml.Conclusion: The data obtained indicate a long-term persistence of markers of the autoimmune process in patients with T1DM. In groups with a long (more than 5 years) course of T1DM, levels of fasting C-peptide more than 30 pmol/L (0.09 ng / ml or 0.03 nmol / L) were noted in 39 (33.6%) cases.

Preservation of C-peptide secretion in subjects at high risk of developing type 1 diabetes mellitus - a new surrogate measure of non-progression?

2004 ◽  
Vol 5 (2) ◽  
pp. 72-79 ◽  
Author(s):  
Desmond Schatz ◽  
David Cuthbertson ◽  
Mark Atkinson ◽  
Michael Clare Salzler ◽  
William Winter ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
High Risk ◽  
Type 1 Diabetes Mellitus ◽  
C Peptide ◽  
Surrogate Measure ◽  
Peptide Secretion
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