Interactions of the humoral pattern recognition molecule PTX3 with the complement system

Immunobiology ◽  
2012 ◽  
Vol 217 (11) ◽  
pp. 1122-1128 ◽  
Author(s):  
Andrea Doni ◽  
Cecilia Garlanda ◽  
Barbara Bottazzi ◽  
Seppo Meri ◽  
Peter Garred ◽  
...  
Keyword(s):  
Pattern Recognition ◽  
Complement System ◽  
The Complement System ◽  
Pattern Recognition Molecule ◽  
Recognition Molecule

scholarly journals C1q/TNF-Related Protein 6 Is a Pattern Recognition Molecule That Recruits Collectin-11 from the Complement System to Ligands

2020 ◽  
Vol 204 (6) ◽  
pp. 1598-1606
Author(s):  
Nikolaj Kirketerp-Møller ◽  
Rafael Bayarri-Olmos ◽  
Karen Angeliki Krogfelt ◽  
Peter Garred
Keyword(s):  
Pattern Recognition ◽  
Complement System ◽  
Related Protein ◽  
The Complement System ◽  
Pattern Recognition Molecule ◽  
Recognition Molecule

scholarly journals THU0019 INTRON REGIONS OF PIK3AP1 (BCAP) AND SPON2 (SPONDIN-2) GENES ARE DIFFERENTIALLY METHYLATED IN PATIENTS WITH PERIODIC FEVER, APHTHOUS STOMATITIS, PHARYNGITIS AND ADENITIS (PFAPA) SYNDROME

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 223.3-223
Author(s):  
E. Lovšin ◽  
J. Kovac ◽  
T. Tesovnik ◽  
N. Toplak ◽  
D. Perko ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Pattern Recognition ◽  
Periodic Fever ◽  
Aphthous Stomatitis ◽  
Extracellular Matrix Protein ◽  
Inflammasome Activation ◽  
Cervical Adenitis ◽  
Pfapa Syndrome ◽  
Pattern Recognition Molecule ◽  
Recognition Molecule

Background:Periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome is the most common autoinflammatory disease in children, often grouped together with hereditary periodic fever syndromes, although its cause and hereditary nature remain unexplained.Objectives:We investigated whether a differential DNA methylation was present in DNA from peripheral blood mononuclear cells (PBMC) in patients with PFAPA versus a group of healthy young individuals.Methods:A whole epigenome analysis (MeDIP and MBD) was performed using pooled DNA libraries enriched for methylated genomic regions. Of identified candidate genes, two with most significantly different methylation leves were further evaluated with methylation specific restriction enzymes coupled with qPCR (MSRE-qPCR).Results:The analysis showed thatPIK3AP1andSPON2intronic gene regions are differentially methylated in patients with PFAPA. MSRE-qPCR proved as a quick, reliable and cost-effective method to confirm results from MeDIP and MBD.Conclusion:Our findings indicate that B cell adapter protein (BCAP) as PI3K binding inhibitor of inflammation and spondin-2 (SPON2) as a pattern recognition molecule and integrin ligand could play a role in etiology of PFAPA. Their role and impact of changed DNA methylation in PFAPA etiology and autoinflammation need further investigation.References:[1]Wekell P. Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome – PFAPA syndrome. Press Medicale [Internet]. 2019;48(1):e77–87. Available from:https://doi.org/10.1016/j.lpm.2018.08.016[2]K. Theodoropoulou, F. Vanoni, and M. Hofer, “Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome: a Review of the Pathogenesis,”Curr. Rheumatol. Rep., vol. 18:18, 2016.[3]Carpentier SJ, Ni M, Duggan JM, James RG, Cookson BT, Hamerman JA. The signaling adaptor BCAP inhibits NLRP3 and NLRC4 inflammasome activation in macrophages through interactions with Flightless-1. Sci Signal. 2019;12(581).[4]He YW, Li H, Zhang J, Hsu CL, Lin E, Zhang N, et al. The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens. Nat Immunol. 2004;5(1):88–97.Disclosure of Interests:None declared

scholarly journals Investigation of Complement-activating Pattern Recognition Molecules and Associated Enzymes as Possible Inflammatory Markers in Oligoarticular and Systemic Juvenile Idiopathic Arthritis

2015 ◽  
Vol 42 (7) ◽  
pp. 1252-1258 ◽  
Author(s):  
Christine Petri ◽  
Steffen Thiel ◽  
Jens Christian Jensenius ◽  
Troels Herlin
Keyword(s):  
Pattern Recognition ◽  
Juvenile Idiopathic Arthritis ◽  
Complement System ◽  
Serine Proteases ◽  
Inflammatory Markers ◽  
Systemic Juvenile Idiopathic Arthritis ◽  
Lectin Pathway ◽  
Paired Samples ◽  
Systemic Jia ◽  
The Complement System

Objective.The complement system plays a crucial role in the pathogenesis of inflammatory processes. The lectin pathway of the complement system is activated through the recognition of pathogens by soluble pattern recognition molecules (PRM), i.e., mannan-binding lectin (MBL), collectin-LK, and the ficolins. PRM are reportedly correlated to disease activity in rheumatoid arthritis (RA). The aim was to evaluate the pathogenic role of PRM in juvenile idiopathic arthritis (JIA).Methods.We measured MBL, M-ficolin, H-ficolin, MBL-associated serine proteases (MASP) 1, MASP-2, MASP-3, and 2 alternative splice products, MBL-associated protein (MAp) 44 and MAp19, in plasma and synovial fluid (SF) of children with persistent oligoarticular (n = 109 in plasma, n = 38 in SF) and systemic JIA (n = 19 in plasma, n = 11 in SF). The concentrations of the proteins were measured by in-house time-resolved immunofluorometric assays.Results.We observed significantly higher levels of M-ficolin, MASP-1, MASP-2, and MASP-3 in plasma and SF from patients with systemic JIA compared with persistent oligoarticular JIA (p < 0.001). In paired samples of plasma and SF from 47 patients with oligoarticular and systemic JIA, we observed higher concentrations in plasma for both subtypes for 7 of the measured proteins while the reverse relationship was observed for MASP-3. M-ficolin and MASP-2 correlated to erythrocyte sedimentation rate, C-reactive protein, white blood cell count, and platelet count (p < 0.001). M-ficolin was in addition related to the number of active joints and inversely related to hemoglobin levels.Conclusion.Our results point to plasma M-ficolin and MASP-2 as inflammatory markers in JIA. The levels of all proteins are higher in plasma than in SF, except for MASP-3, indicating that MASP-3 may be produced locally in joints.

scholarly journals Studies of the Pattern Recognition Molecule H-ficolin

2012 ◽  
Vol 287 (11) ◽  
pp. 8071-8081 ◽  
Author(s):  
Rikke M. Zacho ◽  
Lisbeth Jensen ◽  
Randi Terp ◽  
Jens C. Jensenius ◽  
Steffen Thiel
Keyword(s):  
Pattern Recognition ◽  
Pattern Recognition Molecule ◽  
Recognition Molecule

scholarly journals Structure of the F-spondin domain of mindin, an integrin ligand and pattern recognition molecule

2009 ◽  
Vol 28 (3) ◽  
pp. 286-297 ◽  
Author(s):  
Yili Li ◽  
Chunzhang Cao ◽  
Wei Jia ◽  
Lily Yu ◽  
Min Mo ◽  
...  
Keyword(s):  
Pattern Recognition ◽  
Integrin Ligand ◽  
Pattern Recognition Molecule ◽  
Recognition Molecule

scholarly journals PTX3, a humoral pattern recognition molecule at the interface between microbe and matrix recognition

2016 ◽  
Vol 38 ◽  
pp. 39-44 ◽  
Author(s):  
Cecilia Garlanda ◽  
Sebastien Jaillon ◽  
Andrea Doni ◽  
Barbara Bottazzi ◽  
Alberto Mantovani
Keyword(s):  
Pattern Recognition ◽  
Pattern Recognition Molecule ◽  
Recognition Molecule

scholarly journals The Therapeutic Potential of the Humoral Pattern Recognition Molecule PTX3 in Chronic Lung Infection Caused by Pseudomonas aeruginosa

2011 ◽  
Vol 186 (9) ◽  
pp. 5425-5434 ◽  
Author(s):  
Federica Moalli ◽  
Moira Paroni ◽  
Tania Véliz Rodriguez ◽  
Federica Riva ◽  
Nadia Polentarutti ◽  
...  
Keyword(s):  
Pattern Recognition ◽  
Pseudomonas Aeruginosa ◽  
Therapeutic Potential ◽  
Lung Infection ◽  
Chronic Lung Infection ◽  
Pattern Recognition Molecule ◽  
Recognition Molecule

Properdin: Emerging Roles of a Pattern-Recognition Molecule

2010 ◽  
Vol 28 (1) ◽  
pp. 131-155 ◽  
Author(s):  
Claudia Kemper ◽  
John P. Atkinson ◽  
Dennis E. Hourcade
Keyword(s):  
Pattern Recognition ◽  
Pattern Recognition Molecule ◽  
Recognition Molecule

scholarly journals L-ficolin Is a Pattern Recognition Molecule Specific for Acetyl Groups

2004 ◽  
Vol 279 (46) ◽  
pp. 47513-47519 ◽  
Author(s):  
Anders Krarup ◽  
Steffen Thiel ◽  
Annette Hansen ◽  
Teizo Fujita ◽  
Jens C. Jensenius
Keyword(s):  
Pattern Recognition ◽  
Pattern Recognition Molecule ◽  
Recognition Molecule
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