Expression of let-7i is associated with Toll-like receptor 4 signal in coronary artery disease: Effect of statins on let-7i and Toll-like receptor 4 signal

Immunobiology ◽  
2012 ◽  
Vol 217 (5) ◽  
pp. 533-539 ◽  
Author(s):  
Mamoru Satoh ◽  
Tsuyoshi Tabuchi ◽  
Yoshitaka Minami ◽  
Yuji Takahashi ◽  
Tomonori Itoh ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Artery Disease ◽  
Disease Effect

Expression of miR-146a/b is associated with the Toll-like receptor 4 signal in coronary artery disease: effect of renin–angiotensin system blockade and statins on miRNA-146a/b and Toll-like receptor 4 levels

2010 ◽  
Vol 119 (9) ◽  
pp. 395-405 ◽  
Author(s):  
Yuji Takahashi ◽  
Mamoru Satoh ◽  
Yoshitaka Minami ◽  
Tsuyoshi Tabuchi ◽  
Tomonori Itoh ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Peripheral Blood ◽  
Combined Treatment ◽  
Renin Angiotensin System ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Angiotensin System ◽  
Tlr4 Mrna ◽  
Artery Disease

The TLR4 (Toll-like receptor 4) signal plays an important role in immunity in CAD (coronary artery disease). miR-146a/b (where miR is microRNA) regulates the TLR4 downstream molecules IRAK1 (interleukin-1-receptor-associated kinase 1) and TRAF6 (tumour-necrosis-factor-receptor-associated factor 6). It has also been reported that statins and RAS (renin–angiotensin system) inhibition and have anti-atherosclerotic properties. In the present study, we have investigated whether miR-146a/b was expressed with the TLR4 signal in CAD patients, and whether combined treatment with a statin and RAS inhibition might affect these levels. A total of 66 patients with CAD and 33 subjects without CAD (non-CAD) were enrolled. Patients with CAD were randomized to 12 months of combined treatment with atorvastatin and telmisartan [an ARB (angiotensin II receptor blocker)] or atorvastatin and enalapril [an ACEI (angiotensin-converting enzyme inhibitor)]. PBMCs (peripheral blood mononuclear cells) were obtained from peripheral blood at baseline and after 12 months. Levels of miR-146a/b, IRAK1 mRNA, TRAF6 mRNA and TLR4 mRNA/TLR4 protein were significantly higher in the CAD group than in the non-CAD group (all P<0.01). Levels of miR-146a/b were positively correlated with IRAK1 mRNA and TRAF6 mRNA levels. After 12 months of treatment, these levels were markedly decreased in the ARB and ACEI groups, with the decrease in the ARB group being greater than that in the ACEI group (all P<0.05). In our 12-month follow-up study, high levels of miR-146a and TLR4 mRNA/TLR4 protein at baseline were independent predictors of cardiac events. The present study demonstrates that combined treatment with an ARB and a statin decreases miR-146a/b and the TLR4 signal in CAD patients, possibly contributing to the anti-atherogenic effects of ARBs and statins in this disorder.

Toll–like receptor 4 gene Asp299Gly polymorphism is associated with reductions in vascular inflammation, angiographic coronary artery disease, and clinical diabetes

2004 ◽  
Vol 148 (6) ◽  
pp. 1034-1040 ◽  
Author(s):  
Matthew J. Kolek ◽  
John F. Carlquist ◽  
Joseph B. Muhlestein ◽  
Bryant M. Whiting ◽  
Benjamin D. Horne ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Vascular Inflammation ◽  
Clinical Diabetes ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Artery Disease

Circulating Toll-like receptor 4-responsive microRNA panel in patients with coronary artery disease: results from prospective and randomized study of treatment with renin–angiotensin system blockade

2014 ◽  
Vol 128 (8) ◽  
pp. 483-491 ◽  
Author(s):  
Mamoru Satoh ◽  
Yuji Takahashi ◽  
Tsuyoshi Tabuchi ◽  
Makiko Tamada ◽  
Kan Takahashi ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Randomized Study ◽  
Renin Angiotensin System ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Artery Disease

The present study shows a novel finding that circulating TLR4-responsive miRNAs are associated with activation of TLR4 signal in patients with coronary artery disease (CAD). In conclusion, circulating TLR4-responsive miRNAs may be involved in the pathogenesis of CAD.

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