In Vivo Imaging Reveals Significant Tumor Vascular Dysfunction and Increased Tumor Hypoxia-Inducible Factor-1α Expression Induced by High Single-Dose Irradiation in a Pancreatic Tumor Model

2017 ◽  
Vol 97 (1) ◽  
pp. 184-194 ◽  
Author(s):  
Azusa Maeda ◽  
Yonghong Chen ◽  
Jiachuan Bu ◽  
Hilda Mujcic ◽  
Bradly G. Wouters ◽  
...  
Keyword(s):  
Single Dose ◽  
In Vivo Imaging ◽  
Pancreatic Tumor ◽  
Vascular Dysfunction ◽  
Hypoxia Inducible Factor ◽  
Tumor Hypoxia ◽  
Tumor Model ◽  
Dose Irradiation ◽  
High Single Dose

scholarly journals Targeted In vivo Imaging of Integrin αvβ6 with an Improved Radiotracer and Its Relevance in a Pancreatic Tumor Model

2009 ◽  
Vol 69 (14) ◽  
pp. 5843-5850 ◽  
Author(s):  
Sven H. Hausner ◽  
Craig K. Abbey ◽  
Richard J. Bold ◽  
M. Karen Gagnon ◽  
Jan Marik ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Pancreatic Tumor ◽  
Tumor Model ◽  
Integrin Αvβ6

scholarly journals In Vivo Imaging of Hypoxia-Inducible Factor Regulation in a Subcutaneous and Orthotopic GL261 Glioma Tumor Model Using a Reporter Gene Assay

2014 ◽  
Vol 13 (9) ◽  
pp. 7290.2014.00029 ◽  
Author(s):  
Sandra Bürgi ◽  
Aline Seuwen ◽  
Ruth Keist ◽  
Johannes vom Berg ◽  
Joanes Grandjean ◽  
...  
Keyword(s):  
Reporter Gene ◽  
In Vivo Imaging ◽  
Hypoxia Inducible Factor ◽  
Tumor Model ◽  
Reporter Gene Assay ◽  
Gene Assay ◽  
Glioma Tumor ◽  
Gl261 Glioma

scholarly journals The antitumor efficiency of combined electrochemotherapy and single dose irradiation on a breast cancer tumor model

2012 ◽  
Vol 46 (3) ◽  
Author(s):  
Elham Raeisi ◽  
Seyed Aghamiri ◽  
Azin Bandi ◽  
Negar Rahmatpour ◽  
Seyed Firoozabadi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Single Dose ◽  
Tumor Model ◽  
Dose Irradiation ◽  
Cancer Tumor

Stereotactic, high single-dose irradiation of stage I non-small cell lung cancer (NSCLC) using four-dimensional CT scans for treatment planning

Lung Cancer ◽  
2008 ◽  
Vol 60 (2) ◽  
pp. 193-199 ◽  
Author(s):  
Peter Fritz ◽  
Hans-Jörg Kraus ◽  
Thomas Blaschke ◽  
Werner Mühlnickel ◽  
Konstantin Strauch ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Single Dose ◽  
Small Cell Lung Cancer ◽  
Treatment Planning ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Ct Scans ◽  
Small Cell Lung ◽  
Dose Irradiation ◽  
High Single Dose

scholarly journals Longitudinal and multimodal in vivo imaging of tumor hypoxia and its downstream molecular events

2009 ◽  
Vol 106 (33) ◽  
pp. 14004-14009 ◽  
Author(s):  
S. Lehmann ◽  
D. P. Stiehl ◽  
M. Honer ◽  
M. Dominietto ◽  
R. Keist ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Tumor Hypoxia ◽  
Molecular Events

scholarly journals Adaptive stimulation of macropinocytosis overcomes aspartate limitation in cancer cells under hypoxia

2021 ◽  
Author(s):  
Javier Garcia-Bermudez ◽  
Sheela Prasad ◽  
Lou Baudrier ◽  
Michael A. Badgley ◽  
Yuyang Liu ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Pancreatic Tumor ◽  
Hypoxia Inducible Factor ◽  
Culture Conditions ◽  
Tumor Formation ◽  
High Plasticity ◽  
Hypoxic Conditions ◽  
Adaptive Mechanisms ◽  
Signaling Axis

ABSTRACTStress-adaptive mechanisms enable tumor cells to overcome metabolic constraints in nutrient and oxygen poor tumors. Aspartate is an endogenous metabolic limitation under hypoxic conditions, but the nature of the adaptive mechanisms that contribute to aspartate availability and hypoxic tumor growth are poorly understood. Here, using a combination of metabolomics and CRISPR-based genetic screens, we identify GOT2-catalyzed mitochondrial aspartate synthesis as an essential metabolic dependency for the proliferation of pancreatic tumor cells under hypoxic culture conditions. In contrast, GOT2-catalyzed aspartate synthesis is dispensable for pancreatic tumor formation in vivo. The dependence of pancreatic tumor cells on aspartate synthesis is bypassed in part by a hypoxia-induced potentiation of extracellular protein scavenging via macropinocytosis. This effect is mutant KRas-dependent, and is mediated by hypoxia inducible factor 1 (HIF1A) and its canonical target carbonic anhydrase-9 (CA9) through the cooption of the bicarbonate-macropinocytosis signaling axis. Our findings reveal high plasticity of aspartate metabolism and define an adaptive regulatory role for macropinocytosis by which mutant KRas tumors can overcome nutrient deprivation under hypoxic conditions.

scholarly journals Enriched pharmacokinetic behavior and antitumor efficacy of thymoquinone by liposomal delivery

Nanomedicine ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. 641-656
Author(s):  
Hari Krishnareddy Rachamalla ◽  
Santanu Bhattacharya ◽  
Ajaz Ahmad ◽  
Kathyayani Sridharan ◽  
Vijay Sagar Madamsetty ◽  
...  
Keyword(s):  
Pancreatic Tumor ◽  
Tumor Model ◽  
Volume Of Distribution ◽  
Liposomal Formulation ◽  
Ethanol Injection ◽  
Anticancer Efficacy ◽  
Anticancer Effects ◽  
Systemic Bioavailability ◽  
Pharmacokinetic Behavior

Background: Thymoquinone (TQ) has potential anti-inflammatory, immunomodulatory and anticancer effects but its clinical use is limited by its low solubility, poor bioavailability and rapid clearance. Aim: To enhance systemic bioavailability and tumor-specific toxicity of TQ. Materials & methods: Cationic liposomal formulation of TQ (D1T) was prepared via ethanol injection method and their physicochemical properties, anticancer effects in orthotopic xenograft pancreatic tumor model and pharmacokinetic behavior of D1T relative to TQ were evaluated. Results: D1T showed prominent inhibition of pancreatic tumor progression, significantly greater in vivo absorption, approximately 1.5-fold higher plasma concentration, higher bioavailability, reduced volume of distribution and improved clearance relative to TQ. Conclusion: Encapsulation of TQ in cationic liposomal formulation enhanced its bioavailability and anticancer efficacy against xenograft pancreatic tumor.

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