scholarly journals Circulating Cell-Free Human Papillomavirus DNA as a Marker of Treatment Outcome in Patients With HPV-Positive Squamous Cell Head and Neck Cancer After Radio(chemo) Therapy

2016 ◽  
Vol 96 (2) ◽  
pp. S41 ◽  
Author(s):  
T. Rutkowski ◽  
A. Mazurek ◽  
M. Snietura ◽  
A. Wygoda ◽  
U. Bojko ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Treatment Outcome ◽  
Human Papillomavirus ◽  
Head And Neck ◽  
Neck Cancer ◽  
Squamous Cell ◽  
Papillomavirus Dna

Head and Neck Cancer

2018 ◽  
Author(s):  
Everett E Vokes ◽  
Kevin C. Wood
Keyword(s):  
Squamous Cell Carcinoma ◽  
Clinical Trials ◽  
Head And Neck Cancer ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Neck Cancer ◽  
Squamous Cell ◽  
Early Stage Disease ◽  
Metastatic Setting

The most common histology of non-thyroid head and neck cancer is squamous cell carcinoma.  Common risk factors for head and neck malignancies include tobacco and alcohol abuse and viruses, including Epstein-Barr Virus (EBV) and Human Papillomavirus (HPV). Early stage disease is often treated with surgery or radiation therapy alone, while more advanced disease often requires a multi-modality approach including systemic chemotherapy, radiation, and surgical resection.  In the curative setting, current clinical trials are evaluating the de-escalation of therapy in HPV-releated head and neck cancer.  In the metastatic setting, clinical trials have focused on using immunotherapy agents to improve outcomes. This review chapter will discuss the etiology and common presentations of head and neck cancer, and also analyze recent advancements in the treatment of the disease.          Key words: chemoradiation, head and neck cancer, human papillomavirus, immunotherapy, oropharynx, squamous cell carcinoma, treatment deescalation

Head and Neck Cancer

2018 ◽  
Author(s):  
Everett E Vokes ◽  
Kevin C. Wood
Keyword(s):  
Squamous Cell Carcinoma ◽  
Clinical Trials ◽  
Head And Neck Cancer ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Neck Cancer ◽  
Squamous Cell ◽  
Early Stage Disease ◽  
Metastatic Setting

The most common histology of non-thyroid head and neck cancer is squamous cell carcinoma.  Common risk factors for head and neck malignancies include tobacco and alcohol abuse and viruses, including Epstein-Barr Virus (EBV) and Human Papillomavirus (HPV). Early stage disease is often treated with surgery or radiation therapy alone, while more advanced disease often requires a multi-modality approach including systemic chemotherapy, radiation, and surgical resection.  In the curative setting, current clinical trials are evaluating the de-escalation of therapy in HPV-releated head and neck cancer.  In the metastatic setting, clinical trials have focused on using immunotherapy agents to improve outcomes. This review chapter will discuss the etiology and common presentations of head and neck cancer, and also analyze recent advancements in the treatment of the disease.          Key words: chemoradiation, head and neck cancer, human papillomavirus, immunotherapy, oropharynx, squamous cell carcinoma, treatment deescalation

The Epidemiology and Risk Factors of Head and Neck Cancer: a Focus on Human Papillomavirus

2007 ◽  
Vol 86 (2) ◽  
pp. 104-114 ◽  
Author(s):  
C.C.R. Ragin ◽  
F. Modugno ◽  
S.M. Gollin
Keyword(s):  
Risk Factors ◽  
Head And Neck Cancer ◽  
Human Papillomavirus ◽  
Head And Neck ◽  
Neck Cancer ◽  
Squamous Cell ◽  
Strong Association ◽  
The United States ◽  
Hpv Infection ◽  
Future Research

Head and neck cancer was the eighth leading cause of cancer death worldwide in 2000. Although the incidence of head and neck squamous cell carcinoma (HNSCC) in the United States is relatively low, survival is poor and has not improved for several decades. While tobacco and alcohol are the primary risk factors for HNSCC development, epidemiological studies report a strong association with human papillomavirus (HPV) in a subset of HNSCC. More than 95% of cervical squamous cell carcinomas are linked to persistent HPV infection; evidence demonstrates that HPV is a necessary carcinogen. Not all HPV-positive HNSCC express the viral oncogenes ( E6 and E7), which suggests that HPV may function as a carcinogen in a smaller proportion of HNSCC. This review presents our current understanding of the relationship between HPV and HNSCC, and describes future research directions that may lead to a better understanding of the involvement of HPV in head and neck cancer.

scholarly journals Molecular mechanisms of human papillomavirus-related carcinogenesis in head and neck cancer

2017 ◽  
Author(s):  
Farhoud Faraji ◽  
Munfarid Zaidi ◽  
Carole Fakhry ◽  
Daria A. Gaykalova
Keyword(s):  
Squamous Cell Carcinoma ◽  
Head And Neck Cancer ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Neck Cancer ◽  
Squamous Cell ◽  
Molecular Mechanisms ◽  
Specific Data ◽  
Genome Wide

ABSTRACTThis review examines the general cellular and molecular underpinnings of human papillomavirus (HPV)-related carcinogenesis in the context of head and neck squamous cell carcinoma (HNSCC) and focuses on HPV-positive oropharyngeal squamous cell carcinoma in areas for which specific data is available. It covers the major pathways dysregulated in HPV- positive HNSCC and the genome-wide changes associated with this disease.

scholarly journals CXCL14 suppresses human papillomavirus-associated head and neck cancer through antigen-specific CD8+ T-cell responses by upregulating MHC-I expression

Oncogene ◽  
2019 ◽  
Vol 38 (46) ◽  
pp. 7166-7180 ◽  
Author(s):  
Joseph A. Westrich ◽  
Daniel W. Vermeer ◽  
Alexa Silva ◽  
Stephanie Bonney ◽  
Jennifer N. Berger ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Human Papillomavirus ◽  
T Cell ◽  
Head And Neck ◽  
Neck Cancer ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Mhc I ◽  
Cell Responses

Polymorphism in glutathione S-transferases: Susceptibility and treatment outcome for head and neck cancer

Xenobiotica ◽  
2011 ◽  
Vol 41 (12) ◽  
pp. 1122-1130 ◽  
Author(s):  
Munindra Ruwali ◽  
Madhu Singh ◽  
Mohan C. Pant ◽  
Devendra Parmar
Keyword(s):  
Head And Neck Cancer ◽  
Treatment Outcome ◽  
Head And Neck ◽  
Neck Cancer ◽  
Glutathione S Transferases
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