Clinical Outcomes of Biological Effective Dose-Based Fractionated Stereotactic Radiation Therapy for Metastatic Brain Tumors From Non-Small Cell Lung Cancer

2013 ◽  
Vol 85 (4) ◽  
pp. 984-990 ◽  
Author(s):  
Tomohiko Matsuyama ◽  
Kasei Kogo ◽  
Natsuo Oya
Keyword(s):  
Lung Cancer ◽  
Radiation Therapy ◽  
Brain Tumors ◽  
Small Cell Lung Cancer ◽  
Small Cell ◽  
Stereotactic Radiation Therapy ◽  
Biological Effective Dose ◽  
Metastatic Brain Tumors ◽  
Small Cell Lung ◽  
Stereotactic Radiation

Extra-cranial Stereotactic Radiation Therapy (ESRT) in the treatment of inoperable stage 1 & 2 non-small-cell lung cancer patients with highly mobile tumours: a literature review

2010 ◽  
Vol 9 (4) ◽  
pp. 247-259 ◽  
Author(s):  
Emily W. Tooke ◽  
Benjamin Roe
Keyword(s):  
Computed Tomography ◽  
Lung Cancer ◽  
Radiation Therapy ◽  
Small Cell Lung Cancer ◽  
Respiratory Gating ◽  
Small Cell ◽  
Stereotactic Radiation Therapy ◽  
Small Cell Lung ◽  
Stereotactic Radiation ◽  
Stage 1

AbstractObjective: Extra-cranial Stereotactic Radiation Therapy (ESRT) techniques and equipment utilised in the treatment of Stage 1 or 2 inoperable non-small-cell lung cancer (NSCLC); accounting for Respiratory Induced Tumour Motion (RITM).Methods: A narrative review of current world literature.Results: Four main strategies are employed to address RITM: (1) tumour movement minimisation/immobilisation; (2) integration of respiratory movements into planning; (3) respiratory-gating techniques; and (iv) tumour-tracking techniques.Discussion: Analysis of data gathered suggests that due to inherent difficulties with respiratory function, combined with co-morbidities and the level of dose escalation facilitated by ESRT: techniques that do not require patient ability to comply are more likely to be effective with a wider range of patients. Similarly, treatment planning must incorporate accurate four-dimensional (4D) data to ensure target coverage, although setup and verification should be controlled to smaller margins for error.Conclusion: The disparate nature of reporting methods restricts statistical comparison. However, this paper suggests that the ESRT technique using abdominal compression (AC), free-breathing respiratory-gating (FBRG), 4D computed tomography (4DCT) planning, combined with daily on board kV cone beam computed tomography (CBCT) imaging for setup and target verification, is a possible candidate for further treatment regime assessments in large multi-centre trials.

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