Clinicopathologic Comparison of High-dose-rate Endorectal Brachytherapy and Conventional Chemoradiation Therapy Among Patients With Locally Advanced Low Rectal Cancer

2012 ◽  
Vol 84 (3) ◽  
pp. S343-S344
Author(s):  
J. Smith ◽  
A. Wild ◽  
A. Singhi ◽  
S. Raman ◽  
R. Kumar ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Dose Rate ◽  
Locally Advanced ◽  
High Dose Rate ◽  
Chemoradiation Therapy ◽  
Low Rectal Cancer ◽  
High Dose

Preoperative high dose rate endorectal brachytherapy (HDREBT) for locally advanced operable rectal cancer

2004 ◽  
Vol 60 ◽  
pp. S294-S294
Author(s):  
T VUONG ◽  
J PARENT ◽  
L PORTELANCE ◽  
G BOURDON ◽  
C EMOND ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Dose Rate ◽  
Locally Advanced ◽  
High Dose Rate ◽  
High Dose

Analysis of fiducials implanted during endoscopic ultrasound (EUS) for locally advanced rectal cancer patients receiving high-dose rate endorectal brachytherapy (Endo-HDR).

2014 ◽  
Vol 32 (3_suppl) ◽  
pp. 655-655
Author(s):  
Shalini Moningi ◽  
Ashkan Malayeri ◽  
Susan Gearhart ◽  
Jonathan Efron ◽  
Elizabeth C. Wick ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Radiation Therapy ◽  
Dose Rate ◽  
Cancer Patients ◽  
Locally Advanced ◽  
Advanced Rectal Cancer ◽  
Locally Advanced Rectal Cancer ◽  
High Dose Rate ◽  
High Dose ◽  
The Mean

655 Background: Rectal cancer affects over 40,000 patients in the US per year. The current standard of care for patients with localized rectal cancer is neoadjuvant radiation therapy with concurrent chemotherapy (NCRT) followed by surgery; however, it has shown no proven survival benefit for locally advanced rectal cancer patients. Preliminary results show that a short course of radiation therapy, using high-dose rate endorectal brachytherapy (Endo-HDR), may be as effective with less toxicity and delay to time of surgery. This requires the placement of fiducial markers, using an endoscopic ultrasound guided method (EUS), into the tumor for accurate source placement and treatment. Our aim is to compare three different types of fiducials in terms of visibility and migration. Methods: 12 patients with locally advanced rectal cancer that received Endo-HDR and EUS guided fiducial placement were retrospectively evaluated at JHH. Results: 12 patients underwent EUS guided placement of 42 fiducials. For 11 of our 12 patients, the mean number of fiducials placed per patient was 3.63 (SD 1.03) using a 19-gauge needle. One patient received 2 fiducials using a 22- gauge needle. Of the 12 patients that received fiducials, 3 received traditional fiducials (TF), 8 received segmented fiducials (SF) and 1 received foldable fiducials. All fiducials were clearly visible. The mean number of fiducials that detached from implanted site before surgery for patients with TFs was 0.667, and for patients with SFs was 0.875 (p=0.744). The median migration distance, as measured by interfiduciary distance, for segmented fiducials was significantly larger when compared to traditional fiducials (0.45 cm for SF compared to 0.1 cm for TF; p=0.049) Conclusions: SFs appear to be less stable, with regards to migration, in the rectum when compared to traditional fiducials in our patient population. These differences could be due to placement difficulty or operator dependent differences. Improvement in fiducial structure is required in order to help decrease migration and detachment and maximize visualization, which will lead to more accurate administration of Endo-HDR.

High-dose-rate intraoperative radiotherapy for close or positive margins in patients with locally advanced or recurrent rectal cancer

2004 ◽  
Vol 58 (1) ◽  
pp. 106-112 ◽  
Author(s):  
Joost J Nuyttens ◽  
Inger-Karine K Kolkman-Deurloo ◽  
Maarten Vermaas ◽  
Floris T Ferenschild ◽  
Wilfried J Graveland ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Dose Rate ◽  
Locally Advanced ◽  
Intraoperative Radiotherapy ◽  
High Dose Rate ◽  
Recurrent Rectal Cancer ◽  
High Dose ◽  
Positive Margins

Preoperative endorectal high-dose-rate brachytherapy: Pathologic downstaging in locally advanced rectal cancer

Brachytherapy ◽  
2009 ◽  
Vol 8 (2) ◽  
pp. 133
Author(s):  
Maged Ghaly ◽  
Jenny Li ◽  
Kenneth Satchwill ◽  
Donna Serviss ◽  
Carol Giorello ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Dose Rate ◽  
Locally Advanced ◽  
Advanced Rectal Cancer ◽  
Locally Advanced Rectal Cancer ◽  
High Dose Rate ◽  
High Dose ◽  
High Dose Rate Brachytherapy
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