Phase III Study of Preoperative Concurrent Chemoradiotherapy Compared with Preoperative Radiotherapy Alone in the Treatment of Locally Advanced Head and Neck Squamous Cell Carcinoma

2011 ◽  
Vol 81 (2) ◽  
pp. S78-S79
Author(s):  
J. Yi ◽  
G. Li ◽  
X. Huang
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Concurrent Chemoradiotherapy ◽  
Preoperative Radiotherapy ◽  
Locally Advanced ◽  
Phase Iii ◽  
Advanced Head ◽  
Phase Iii Study ◽  
Radiotherapy Alone

scholarly journals Pembrolizumab given concomitantly with chemoradiation and as maintenance therapy for locally advanced head and neck squamous cell carcinoma: KEYNOTE-412

2020 ◽  
Vol 16 (18) ◽  
pp. 1235-1243 ◽  
Author(s):  
Jean-Pascal Machiels ◽  
Yungan Tao ◽  
Barbara Burtness ◽  
Makoto Tahara ◽  
Lisa Licitra ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Treatment Guidelines ◽  
Locally Advanced ◽  
Neck Squamous Cell Carcinoma ◽  
Phase Iii ◽  
Advanced Head ◽  
Double Blind

Current treatment guidelines for patients with locally advanced head and neck squamous cell carcinoma (HNSCC) recommend multimodal treatment, including chemoradiation therapy (CRT) or surgery followed by radiation, with or without chemotherapy. The immune checkpoint inhibitor pembrolizumab has previously demonstrated antitumor activity in recurrent and/or metastatic HNSCC in large Phase III trials. For patients with locally advanced disease, Phase Ib data on the use of pembrolizumab in combination with chemoradiation have shown the approach to be safe and feasible. We describe here the design and rationale for KEYNOTE-412, a randomized, double-blind, Phase III trial investigating pembrolizumab or placebo administered concurrently with CRT and as maintenance treatment in patients with locally advanced HNSCC. Clinical Trial Registration: NCT03040999 ( ClinicalTrials.gov ).

scholarly journals Induction Chemotherapy Followed by Radiotherapy Versus Induction Chemotherapy Followed by Chemoradiotherapy in Locally Advanced Squamous Cell Carcinoma of Head and Neck

KYAMC Journal ◽  
2019 ◽  
Vol 10 (3) ◽  
pp. 128-132
Author(s):  
Md Nazmul Alam ◽  
Md Abdul Bari ◽  
Sarwar Alam ◽  
Md Shahidul Islam ◽  
Tanvir Ahmed
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Induction Chemotherapy ◽  
Squamous Cell ◽  
Concurrent Chemoradiotherapy ◽  
Locally Advanced ◽  
Advanced Squamous Cell Carcinoma ◽  
Radiotherapy Alone ◽  
Grade 3

Background: Radiotherapy and chemotherapy are practiced widely for the treatment of locally advanced squamous cell carcinoma of head and neck Objectives: To compares the effectiveness and toxicities between induction chemotherapy followed by radiotherapy alone and concurrent chemoradiotherapy Materials and Methods: A quasi experimental study was carried out from January 2014 to December 2014. Total sixty patients with locally advanced squamous cell carcinoma of head and neck origin were included and allocated into the arm A and B alternatively. Induction chemotherapy by Cisplatin and 5-Fluorouracil was given to the patient of both arms. Injection Cisplatin was given concurrently during the whole length of radiotherapy period in Arm A while patient in Arm B received radiotherapy alone. The patients were evaluated up to 30 weeks following the completion of the treatment. Results: In this study, male to female ratio was 4:1 and mean age at diagnosis was 60 ± 5 years. Overall complete response was 90% (27/30) and 53.3% (16/30) for the Arm A and Arm B respectively at 30 weeks after completion of treatment. During induction chemotherapy only 5% (3/60) of patients suffered from Grade 3 diarrhoea in both arms. In Arm A Grade 3 and 4 mucositis was observed in 36.66% (11/30) and 3.33% (1/30) of patients respectively whereas in Arm B it was 33.33% (10/30) and 3.33% (1/30) respectively. Conclusion: Induction chemotherapy followed by concurrent chemoradiotherapy is more effective than induction chemotherapy followed by radiotherapy alone in loco-regional control of locally advanced squamous cell carcinoma ofhead and neck origin KYAMC Journal Vol. 10, No.-3, October 2019, Page 128-132

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