Long-Term Quality of Life Outcome After Proton Beam Monotherapy for Localized Prostate Cancer

2012 ◽  
Vol 82 (2) ◽  
pp. e201-e209 ◽  
Author(s):  
John J. Coen ◽  
Jonathan J. Paly ◽  
Andrzej Niemierko ◽  
Elizabeth Weyman ◽  
Anita Rodrigues ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Proton Beam ◽  
Localized Prostate Cancer

scholarly journals Long-term Health-related Quality of Life After Primary Treatment for Localized Prostate Cancer: Results from the CaPSURE Registry

2015 ◽  
Vol 68 (4) ◽  
pp. 600-608 ◽  
Author(s):  
Sanoj Punnen ◽  
Janet E. Cowan ◽  
June M. Chan ◽  
Peter R. Carroll ◽  
Matthew R. Cooperberg
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Primary Treatment ◽  
Localized Prostate Cancer ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

Long-term health-related quality of life in patients treated for localized prostate cancer.

2013 ◽  
Vol 31 (6_suppl) ◽  
pp. 93-93
Author(s):  
Sanoj Punnen ◽  
Janet E. Cowan ◽  
Peter Carroll ◽  
Matthew R. Cooperberg
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Primary Treatment ◽  
Localized Prostate Cancer ◽  
Study Cohort ◽  
Urinary Function ◽  
Primary Treatment Modality ◽  
The Mean

93 Background: Few studies have reported long term quality of life after primary treatment for localized prostate cancer. The objective of this study was report 10 year sexual and urinary quality of life data for men undergoing various treatments in the Cancer of the Prostate Strategy and Research Endeavor database. Methods: Men who have been treated for localized prostate cancer and have baseline and follow up quality of life date made up the study cohort. Primary treatment modalities included radical prostatectomy (RP), external beam radiotherapy (EBRT), brachytherapy (BT), cryotherapy (CT), primary androgen deprivation therapy (ADT), and active surveillance/ watchful waiting (AS/WW). Sexual and urinary quality of life were assessed by the validated UCLA Prostate Cancer Index and measured on a scale from 0-100. Mixed model repeated measures analysis was used to assess the association between primary treatment modality and long term urinary and sexual quality of life. Results: 3, 772 men made up the study cohort. Among all men being treated for prostate cancer the mean urinary function score was 92 at baseline, 76 at 1 year, 81 at 5 years and 77 at 10 years. Urinary bother scores were 84 at baseline, 71 at 1 year, 82 at 5 years, and 78 at 10 years. With respect to sexual function the mean score was 49 at baseline, 23 at 1 year, 29 at 5 years, and 24 at 10 years. Finally, the mean sexual bother score was 59 at baseline, 37 at 1 year, 46 at 5 years, and 47 at 10 years. With respect to quality of life by primary treatment modality most treatments showed a similar pattern of decreased scores in the first year followed by an increased in the following two years and a plateau up to the 10 year mark. EBRT and BT showed a longer decline in sexual and urinary function post treatment while RP scores plateau after 3 years. Conclusions: Men undergoing primary treatment for localized prostate cancer experience declines in sexual and urinary function and bother in the first year which improves after 3 years and plateaus up to 10 years.

Long-term quality of life among localized prostate cancer survivors: Qalipro population-based study.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. 9594-9594
Author(s):  
Anne-Valérie Guizard ◽  
Clarisse Kerleau ◽  
Pascale Grosclaude ◽  
Mariette Mercier ◽  
Natacha Heutte ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Cancer Survivors ◽  
Population Based ◽  
Localized Prostate Cancer ◽  
Population Based Study ◽  
Prostate Cancer Survivors

scholarly journals Treatment Decision Regret Among Long-Term Survivors of Localized Prostate Cancer: Results From the Prostate Cancer Outcomes Study

2017 ◽  
Vol 35 (20) ◽  
pp. 2306-2314 ◽  
Author(s):  
Richard M. Hoffman ◽  
Mary Lo ◽  
Jack A. Clark ◽  
Peter C. Albertsen ◽  
Michael J. Barry ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Decision Making ◽  
Treatment Decision ◽  
Localized Prostate Cancer ◽  
Factors Associated ◽  
Decision Regret ◽  
Long Term Survivors

Purpose To determine the demographic, clinical, decision-making, and quality-of-life factors that are associated with treatment decision regret among long-term survivors of localized prostate cancer. Patients and Methods We evaluated men who were age ≤ 75 years when diagnosed with localized prostate cancer between October 1994 and October 1995 in one of six SEER tumor registries and who completed a 15-year follow-up survey. The survey obtained demographic, socioeconomic, and clinical data and measured treatment decision regret, informed decision making, general- and disease-specific quality of life, health worry, prostate-specific antigen (PSA) concern, and outlook on life. We used multivariable logistic regression analyses to identify factors associated with regret. Results We surveyed 934 participants, 69.3% of known survivors. Among the cohort, 59.1% had low-risk tumor characteristics (PSA < 10 ng/mL and Gleason score < 7), and 89.2% underwent active treatment. Overall, 14.6% expressed treatment decision regret: 8.2% of those whose disease was managed conservatively, 15.0% of those who received surgery, and 16.6% of those who underwent radiotherapy. Factors associated with regret on multivariable analysis included reporting moderate or big sexual function bother (reported by 39.0%; OR, 2.77; 95% CI, 1.51 to 5.0), moderate or big bowel function bother (reported by 7.7%; OR, 2.32; 95% CI, 1.04 to 5.15), and PSA concern (mean score 52.8; OR, 1.01 per point change; 95% CI, 1.00 to 1.02). Increasing age at diagnosis and report of having made an informed treatment decision were inversely associated with regret. Conclusion Regret was a relatively infrequently reported outcome among long-term survivors of localized prostate cancer; however, our results suggest that better informing men about treatment options, in particular, conservative treatment, might help mitigate long-term regret. These findings are timely for men with low-risk cancers who are being encouraged to consider active surveillance.

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