MicroPET/CT Imaging of an Orthotopic Model of Human Glioblastoma Multiforme and Evaluation of Pulsed Low-Dose Irradiation

2011 ◽  
Vol 80 (3) ◽  
pp. 885-892 ◽  
Author(s):  
Sean S. Park ◽  
John L. Chunta ◽  
John M. Robertson ◽  
Alvaro A. Martinez ◽  
Ching-Yee Oliver Wong ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
Low Dose ◽  
Ct Imaging ◽  
Orthotopic Model ◽  
Human Glioblastoma ◽  
Dose Irradiation ◽  
Human Glioblastoma Multiforme

Membranous stacks in human glioblastoma multiforme

1971 ◽  
Vol 18 (3) ◽  
pp. 248-256 ◽  
Author(s):  
Eiichi Tani ◽  
Toshio Ametani
Keyword(s):  
Glioblastoma Multiforme ◽  
Human Glioblastoma ◽  
Human Glioblastoma Multiforme

scholarly journals Lomeguatrib Increases the Radiosensitivity of MGMT Unmethylated Human Glioblastoma Multiforme Cell Lines

2021 ◽  
Vol 22 (13) ◽  
pp. 6781
Author(s):  
Anna Kirstein ◽  
Daniela Schilling ◽  
Stephanie E. Combs ◽  
Thomas E. Schmid
Keyword(s):  
Glioblastoma Multiforme ◽  
Cell Lines ◽  
Dna Methyltransferase ◽  
Treatment Options ◽  
Treatment Resistance ◽  
Cell Cycle Distribution ◽  
Human Glioblastoma ◽  
Human Glioblastoma Multiforme ◽  
Mgmt Protein

Background: Treatment resistance of glioblastoma multiforme to chemo- and radiotherapy remains a challenge yet to overcome. In particular, the O6-methylguanine-DNA-methyltransferase (MGMT) promoter unmethylated patients have only little benefit from chemotherapy treatment using temozolomide since MGMT counteracts its therapeutic efficacy. Therefore, new treatment options in radiotherapy need to be developed to inhibit MGMT and increase radiotherapy response. Methods: Lomeguatrib, a highly specific MGMT inhibitor, was used to inactivate MGMT protein in vitro. Radiosensitivity of established human glioblastoma multiforme cell lines in combination with lomeguatrib was investigated using the clonogenic survival assay. Inhibition of MGMT was analyzed using Western Blot. Cell cycle distribution and apoptosis were investigated to determine the effects of lomeguatrib alone as well as in combination with ionizing radiation. Results: Lomeguatrib significantly decreased MGMT protein and reduced radiation-induced G2/M arrest. A radiosensitizing effect of lomeguatrib was observed when administered at 1 µM and increased radioresistance at 20 µM. Conclusion: Low concentrations of lomeguatrib elicit radiosensitization, while high concentrations mediate a radioprotective effect.

scholarly journals NFATc1 activation promotes the invasion of U251 human glioblastoma multiforme cells through COX-2

2015 ◽  
Vol 35 (5) ◽  
pp. 1333-1340 ◽  
Author(s):  
LAIZANG WANG ◽  
ZHI WANG ◽  
JIANHUA LI ◽  
WEIGUANG ZHANG ◽  
FUBIN REN ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
Human Glioblastoma ◽  
Human Glioblastoma Multiforme ◽  
Cox 2

Heterogeneity, polyploidy, aneusomy, and 9p deletion in human glioblastoma multiforme

1995 ◽  
Vol 83 (2) ◽  
pp. 127-135 ◽  
Author(s):  
Se Hyuck Park ◽  
Tatsuhiro Maeda ◽  
Gayatry Mohapatra ◽  
Frederic M. Waldman ◽  
Richard L. Davis ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
Human Glioblastoma ◽  
Human Glioblastoma Multiforme
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