A Systematic Assessment of Radiation Dose Enhancement by 5-Aza-2′-Deoxycytidine and Histone Deacetylase Inhibitors in Head-and-Neck Squamous Cell Carcinoma

2009 ◽  
Vol 73 (3) ◽  
pp. 904-912 ◽  
Author(s):  
Harlinde De Schutter ◽  
Marlies Kimpe ◽  
Sofie Isebaert ◽  
Sandra Nuyts
Keyword(s):  
Squamous Cell Carcinoma ◽  
Radiation Dose ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Histone Deacetylase ◽  
Squamous Cell ◽  
Histone Deacetylase Inhibitors ◽  
Neck Squamous Cell Carcinoma ◽  
Dose Enhancement ◽  
Systematic Assessment

scholarly journals Examining adjuvant radiation dose in head and neck squamous cell carcinoma

Head & Neck ◽  
2019 ◽  
Vol 41 (7) ◽  
pp. 2133-2142 ◽  
Author(s):  
Vladimir Avkshtol ◽  
Elizabeth A. Handorf ◽  
John A. Ridge ◽  
Brooke K. Leachman ◽  
Jeffrey C. Liu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Radiation Dose ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Adjuvant Radiation

scholarly journals Patterns of recurrence after low-dose postoperative radiotherapy for head and neck squamous cell carcinoma

2021 ◽  
Vol 33 (1) ◽  
Author(s):  
Wataru Makino ◽  
Joichi Heianna ◽  
Kazuki Ishikawa ◽  
Takeaki Kusada ◽  
Hitoshi Maemoto ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
High Risk ◽  
Radiation Dose ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Postoperative Radiotherapy ◽  
Neck Squamous Cell Carcinoma ◽  
Oral Cavity Carcinoma ◽  
Risk Patients

Abstract Background Postoperative chemoradiotherapy is recommended for patients with head and neck squamous cell carcinoma with positive margins or extracapsular extension at high risk of recurrence. However, high-dose radiotherapy in the head and neck region often causes severe acute and late radiation-related adversities. In our institution, the radiation dose has been relatively lower than that used in Western countries to reduce radiation-related toxicities. Therefore, in this study, we examined the treatment outcomes of low-dose postoperative chemoradiotherapy. Methods The outcomes of 90 consecutive head and neck squamous cell carcinoma patients who received postoperative radiotherapy between June 2009 and December 2016 were retrospectively analyzed. All patients received postoperative three-dimensional conformal radiotherapy with or without concurrent systemic chemotherapy. The median patient age was 65 years. Concurrent chemoradiotherapy was administered at a total dose of 50.4 Gy in 28 fractions (daily fraction, 1.8 Gy). High-risk patients received 10.8 Gy of boost irradiation in six fractions. For radiotherapy alone, the irradiation dose was up to 54 Gy in 30 fractions and 64.8 Gy in 36 fractions for high-risk patients to increase the treatment intensity. Results The median follow-up period was 40.5 months. The 3-year locoregional control and overall survival rates were 67.5% and 82.7%, respectively. A significantly higher proportion of patients with oral cavity carcinoma experienced locoregional failure (p = 0.004). The acute adverse events were mild, and the only late adverse event was grade 3 dysphagia (n = 3). Conclusion This study suggests that de-escalation of the postoperative radiation dose can potentially reduce the severe adverse events of irradiation in patients while ensuring its effectiveness. In patients with oral cavity carcinoma, it might be necessary to increase the radiation dose.

scholarly journals Alteration of cancer stem cell-like phenotype by histone deacetylase inhibitors in squamous cell carcinoma of the head and neck

2013 ◽  
Vol 104 (11) ◽  
pp. 1468-1475 ◽  
Author(s):  
Kazuaki Chikamatsu ◽  
Hiroki Ishii ◽  
Takaaki Murata ◽  
Koichi Sakakura ◽  
Masato Shino ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Histone Deacetylase ◽  
Squamous Cell ◽  
Histone Deacetylase Inhibitors
Sign in / Sign up

Export Citation Format

Share Document