The impact of lobular carcinoma in situ in association with invasive breast cancer on the rate of local recurrence in patients with early-stage breast cancer treated with breast-conserving therapy

2006 ◽  
Vol 66 (2) ◽  
pp. 365-371 ◽  
Author(s):  
Shruti Jolly ◽  
Larry L. Kestin ◽  
Neal S. Goldstein ◽  
Frank A. Vicini
Keyword(s):  
Breast Cancer ◽  
Local Recurrence ◽  
Invasive Breast Cancer ◽  
Carcinoma In Situ ◽  
Early Stage ◽  
Lobular Carcinoma ◽  
Breast Conserving Therapy ◽  
Lobular Carcinoma In Situ ◽  
The Impact

scholarly journals Associations of race and ethnicity with risk of developing invasive breast cancer after lobular carcinoma in situ

2019 ◽  
Vol 21 (1) ◽  
Author(s):  
Vanessa Dania ◽  
Ying Liu ◽  
Foluso Ademuyiwa ◽  
Jason D. Weber ◽  
Graham A. Colditz
Keyword(s):  
Breast Cancer ◽  
Black Women ◽  
Racial Differences ◽  
Invasive Breast Cancer ◽  
Hormone Receptor ◽  
Carcinoma In Situ ◽  
White Women ◽  
Lobular Carcinoma ◽  
Lobular Carcinoma In Situ

Abstract Background Lobular carcinoma in situ (LCIS) of the breast is a risk factor of developing invasive breast cancer. We evaluated the racial differences in the risks of subsequent invasive breast cancer following LCIS. Methods We utilized data from the Surveillance, Epidemiology, and End Results registries to identify 18,835 women diagnosed with LCIS from 1990 to 2015. Cox proportional hazards regression was used to estimate race/ethnicity-associated hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) of subsequent invasive breast cancer. Results During a median follow-up of 90 months, 1567 patients developed invasive breast cancer. The 10-year incidence was 7.9% for Asians, 8.2% for Hispanics, 9.3% for whites, and 11.2% for blacks (P = 0.046). Compared to white women, black women had significantly elevated risks of subsequent invasive breast cancer (HR 1.33; 95% CI 1.11, 1.59), and invasive cancer in the ipsilateral breast (HR 1.37; 95% CI 1.08, 1.72) and in the contralateral breast (HR 1.33; 95% CI 1.00, 1.76). Black women had significantly higher risks of invasive subtypes negative for both estrogen receptor and progesterone receptor (HR 1.86; 95% CI 1.14, 3.03) and invasive subtypes positive for one or both of receptors (HR 1.30; 95% CI 1.07, 1.59). The risk of subsequent invasive breast cancer was comparable in Asian women and Hispanic women compared with white women. Conclusions Black women had a significantly higher risk of developing invasive breast cancer, including both hormone receptor-positive and hormone receptor-negative subtypes, after LCIS compared with white counterparts. It provides an opportunity to address health disparities.

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