New findings in the identification of adult vitamin D deficiency osteomalacia: Results from a large-scale study

2014 ◽  
Vol 7 ◽  
pp. 45-56 ◽  
Author(s):  
Rachel Ives ◽  
Megan Brickley
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Large Scale ◽  
Large Scale Study ◽  
New Findings

scholarly journals Vitamin D: new aspects of application, effective doses. The current state of the problem

2021 ◽  
Vol 17 (1) ◽  
pp. 38-42
Author(s):  
I.V. Pankiv
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Large Scale ◽  
Randomized Clinical Trials ◽  
Adult Population ◽  
Daily Intake ◽  
Age Related ◽  
The Status ◽  
Low Efficiency ◽  
Age Related Cognitive Decline

In addition to the classic role of vitamin D in maintaining the normal state of the musculoskeletal system in the last decade, there is evidence that reduced serum concentrations of 25(OH)D are associated with a number of extraskeletal diseases (diabetes mellitus, hypertension, thyroid diseases, age-related cognitive decline, dysfunction of the immune and reproductive systems, etc.). Prevention of these diseases is achieved with significantly higher concentrations of 25(OH)D in the serum than those necessary to maintain normal bone tissue, regulate absorption and maintain calcium homeostasis. To ensure the concentration of the circulating form of vitamin D — 25(OH)D in the serum at a level that ensures optimal functioning, you need a higher consumption of this vitamin. Decreased blood concentration of vitamin D (< 30 ng/ml) is observed in 92 % of the adult population of Ukraine, regardless of the season. The causes of vitamin D deficiency are the low efficiency of its endogenous synthesis in the skin due to insufficient insolation and inadequate intake of this vitamin with food. Due to the half-life of vitamin D of about two months, periodic weekly or monthly intake of total doses of cholecalciferol provides the same values in the serum as daily intake. The review of the lite­rature considers the importance of vitamin D deficiency and deficiency in disorders of many systems of the human body and the development of various pathological conditions, which justifies the wider use of methods to correct the status of vitamin D. Despite the need for large-scale randomized clinical trials to determine the use of vitamin D, now there is no doubt that the normalization of the level of 25(OH)D in the serum is required at all age stages of ontogenesis.

Frequency of Vitamin D deficiency in Coronary artery disease patients following up in tertiary care cardiac center in Lahore

2021 ◽  
Vol 15 (10) ◽  
pp. 2559-2560
Author(s):  
Attaullah Khan Niazi ◽  
Muhammed Muneeb ◽  
Kanza Sana Umer ◽  
Ammar Hameed Khan ◽  
Kiran Manzar ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Vitamin D ◽  
Coronary Artery ◽  
Vitamin D Deficiency ◽  
Large Scale ◽  
Demographic Data ◽  
Tertiary Care ◽  
Cross Sectional ◽  
Artery Disease ◽  
Cardiac Center

Aim: To find out frequency of Vit. D deficiency in Coronary artery disease following up in tertiary care cardiac center Method: It is Purposive Cross-sectional study, Duration study period of two months in which 228 patients attended out clinic and underwent admission at department of cardiology & cardiovascular surgery, Data collection tool (a struc-tured questionnaire) consists of demographic data, Vitamin d3 level, details of medications and co-angulation factors, ECG findings and expected Echocardiogram findings Result: The subjects were severely deficient in vitamin D and its levels were inversely correlated with most of the com-ponents of metabolic syndrome. A Vitamin D deficiency is stirring the Pakistan rural population regardless of their age, gender, and the results of this study’s result have showed that this vitamin D deficiency is crucial in Pakistan. However, large scale studies are required to verify our findings. Keywords: Cardiovascular disease, Vitamin D. deficiency, Coronary artery disease, Malnutrition

scholarly journals Vitamin D and colon cancer

2012 ◽  
Vol 19 (3) ◽  
pp. R51-R71 ◽  
Author(s):  
Fábio Pereira ◽  
María Jesús Larriba ◽  
Alberto Muñoz
Keyword(s):  
Colon Cancer ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Large Scale ◽  
Molecular Genetic ◽  
Experimental Studies ◽  
Human Colon ◽  
Cell Phenotype ◽  
Bone Biology ◽  
Dihydroxyvitamin D

The most active vitamin D metabolite, 1α,25-dihydroxyvitamin D3(1,25(OH)2D3), is a pleiotropic hormone with wide regulatory actions. Classically, vitamin D deficiency was known to alter calcium and phosphate metabolism and bone biology. In addition, recent epidemiological and experimental studies support the association of vitamin D deficiency with a large variety of human diseases, and particularly with the high risk of colorectal cancer. By regulating the expression of many genes via several mechanisms, 1,25(OH)2D3induces differentiation, controls the detoxification metabolism and cell phenotype, sensitises cells to apoptosis and inhibits the proliferation of cultured human colon carcinoma cells. Consistently, 1,25(OH)2D3and several of its analogues decrease intestinal tumourigenesis in animal models. Molecular, genetic and clinical data in humans are scarce but they suggest that vitamin D is protective against colon cancer. Clearly, the available evidence warrants new, well-designed, large-scale trials to clarify the role of vitamin D in the prevention and/or therapy of this important neoplasia.

scholarly journals Evidence Regarding Vitamin D and Risk of COVID-19 and Its Severity

Nutrients ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3361 ◽  
Author(s):  
Joseph Mercola ◽  
William B. Grant ◽  
Carol L. Wagner
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Skin Color ◽  
Large Scale ◽  
Therapeutic Window ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Vitamin D Supplements ◽  
Tract Infections ◽  
Endothelial Integrity

Vitamin D deficiency co-exists in patients with COVID-19. At this time, dark skin color, increased age, the presence of pre-existing illnesses and vitamin D deficiency are features of severe COVID disease. Of these, only vitamin D deficiency is modifiable. Through its interactions with a multitude of cells, vitamin D may have several ways to reduce the risk of acute respiratory tract infections and COVID-19: reducing the survival and replication of viruses, reducing risk of inflammatory cytokine production, increasing angiotensin-converting enzyme 2 concentrations, and maintaining endothelial integrity. Fourteen observational studies offer evidence that serum 25-hydroxyvitamin D concentrations are inversely correlated with the incidence or severity of COVID-19. The evidence to date generally satisfies Hill’s criteria for causality in a biological system, namely, strength of association, consistency, temporality, biological gradient, plausibility (e.g., mechanisms), and coherence, although experimental verification is lacking. Thus, the evidence seems strong enough that people and physicians can use or recommend vitamin D supplements to prevent or treat COVID-19 in light of their safety and wide therapeutic window. In view of public health policy, however, results of large-scale vitamin D randomized controlled trials are required and are currently in progress.

Study of Vitamin D Deficiency in Adolescent Females (10-18 years old) In Cairo

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
R M Botros ◽  
Y M Eid ◽  
B M Mostafa ◽  
Y H E Elmeligy
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Large Scale ◽  
Age Groups ◽  
Sun Exposure ◽  
Adolescent Females ◽  
Contributing Factors ◽  
Significant Difference ◽  
High Prevalence ◽  
Deficient Group

Abstract Background Vitamin D deficiency is a common problem among Egyptian females across all age groups, for whom contributing factors include inadequate sun exposure possibly related to cultural/social factors, and insufficient dietary calcium, wearing a sunscreen reduces vitamin D synthesis in the skin by more than 95%. Not only environmental factors, such as sun exposure and nutrition, but also genetic and possibly also epigenetic factors are determinants of serum 25(OH) D. Aim We sought to determine the frequency of occurrence of vit D deficiency in Egyptian adolescent females aged 10-18 years in Cairo. Methods Study was conducted on 90 healthy adult females aged (10-18) years and classified them into: Sufficient group: with vitamin D level &gt;30ng/ml, (40%) of participants. Mild deficient group: with vitamin D level between 21-29ng/ml (14.44%) of participants. Moderate deficient group: with vitamin D level between 10-20ng/ml (11.11%) of participants. Severe deficient group: with vitamin D level &lt;10ng/ml (34.44%) of participants. Results Our study showed a high prevalence of low vitamin D level among healthy adolescent females aged (10-18) years old. There were a significant difference On comparing vitamin D status groups as regard vitamin D rich food intake, duration of sun exposure and height for age (p &lt; 0.001), (p &lt; 0.001) and (p = 0.012) respectively. There were significant difference on comparing vit D status groups with s.Ca, PTH and Alk.Ph (p &lt; 0.001). Conclusion Vitamin D deficiency became endemic in Egypt. Large-scale studies are needed to properly evaluate the size of the problem.

scholarly journals Treatment with Vitamin D3 in Vitamin D Deficient Adolescents: A Pilot Study

2020 ◽  
Vol 7 ◽  
pp. 2333794X2097624
Author(s):  
Mohan Kumaratne ◽  
Franck Vigneron ◽  
Jasmine Cisneros
Keyword(s):  
Vitamin D ◽  
Pilot Study ◽  
Vitamin D Deficiency ◽  
Vitamin D3 ◽  
Large Scale ◽  
Optimal Dose ◽  
Epidemiological Studies ◽  
Case Control Studies ◽  
Vitamin D Levels ◽  
The Usa

Multiple epidemiological studies have shown that vitamin D deficiency is highly prevalent amongst adolescents in the USA. However, recommendations regarding the treatment of vitamin D deficiency in healthy adolescents are not well defined. We carried out a prospective pilot study, to determine whether treatment with 2000 international units of vitamin D3 daily for 3 months, would normalize the vitamin D levels in vitamin D deficient adolescents. Following treatment there was a 56.02% increase in the vitamin D levels from the mean baseline values and 80.39% of the subjects normalized their vitamin D levels. There were no adverse effects associated with this intervention. This study offers complementary guidelines to the existing recommendations from the American Academy of Pediatrics on the optimal dose and duration of vitamin D3 therapy in vitamin D deficient, but otherwise healthy adolescents. Further prospective, large scale, case control studies are indicated to validate our results.

scholarly journals Association of Vitamin D Deficiency with Hepatitis B and C Virus Infection

2021 ◽  
pp. 10-14
Author(s):  
Darshan Kumar ◽  
Muhammad Umar Khan ◽  
Syed Mohammad Kashif ◽  
Majid Ahmed Shaikh ◽  
Zunaira Nawaz ◽  
...  
Keyword(s):  
Vitamin D ◽  
Hepatitis C ◽  
Virus Infection ◽  
Hepatitis B ◽  
Vitamin D Deficiency ◽  
Large Scale ◽  
Hbv Dna ◽  
Hcv Rna ◽  
Serological Tests ◽  
Vitamin D Levels

Objective: To evaluate the association of vitamin D deficiency with hepatitis B and C virus Infection. Study Design: This is a prospective study. Setting: Study carried out at Medicine department Civil Hospital Karachi, from March, 2018 to December, 2019. Materials and Methods:  266 Participants of the study included patients with active hepatitis B or hepatitis C infection visiting OPD of the hospital. Vitamin D levels of 14-30 ng/ml have been described as insufficient and levels <14 ng/ml are labelled as deficient. Vitamin D level of >30 nm/ml have been defined as sufficient according to our study. Diagnosis of Hepatitis B is confirmed by HBV DNA and HBsAg serum levels and of Hepatitis C by HCV RNA levels. Results: We received 70.6% (n=266) males and 29.3% females. After serological tests 34.9% (n=93) patients were positive for HBV DNA whereas 47.7% (n=127) patients were positive for HCV DNA. Coinfection with hepatitis B and C was present in 17.2% (n=46) of patients. Amongst total 266 participants 54.31% patients have been vitamin D deficient and 32.7% have insufficient vitamin D levels. Conclusion: Genetic and metabolic factors linked to hepatitis B and C with vitamin D deficiency should be studied on large scale. In our study patients infected with HBV and HCV have been vitamin D deficient, supplementation needs to be added to the treatment regimen.

scholarly journals Isolated Vitamin D Deficiency Is Not Associated with Nonthyroidal Illness Syndrome, but with Thyroid Autoimmunity

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Muyesser Sayki Arslan ◽  
Oya Topaloglu ◽  
Bekir Ucan ◽  
Melia Karakose ◽  
Basak Karbek ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Large Scale ◽  
Thyroid Autoimmunity ◽  
Inverse Correlation ◽  
Thyroid Function Test ◽  
Nonthyroidal Illness ◽  
Thyroid Autoantibody ◽  
The Difference ◽  
Test Result

Aim. This study aimed to compare thyroid functions, thyroid autoantibodies, and the existence of nonthyroidal illness syndrome (NTIS) according to vitamin D level.Materials and Methods. The study included age- and BMI-matched healthy volunteers with and without vitamin D deficiency. In addition, the nonthyroidal illness syndrome status was evaluated.Results. Anti-TPO positivity was significantly more common in those with severe and moderate vitamin D deficiency, as compared to those with a normal 25(OH)D level. Furthermore, TSH levels were significantly lower in those with severe and moderate vitamin D deficiency than in those with a normal 25(OH)D level. In addition, there was a significant weak inverse correlation between anti-TPO positivity and the 25(OH)D level and a positive correlation between the TSH level and 25(OH)D level. Only 1 thyroid function test result was compatible with NTIS among the participants with moderate vitamin D deficiency; therefore the difference was not significant.Conclusions. The prevalence of thyroid autoantibody positivity was higher in those with severe and moderate vitamin D deficiency than in those with a normal 25(OH)D level. Additional large-scale studies must be conducted to determine if vitamin D deficiency plays a causal role in the pathogenesis of Hashimoto’s thyroiditis and NTIS.

scholarly journals Vitamin D deficiency in Russia: the first results of a registered, non-interventional study of the frequency of vitamin D deficiency and insufficiency in various geographic regions of the country

2021 ◽  
Vol 67 (2) ◽  
pp. 84-92
Author(s):  
V. A. Avdeeva ◽  
L. A. Suplotova ◽  
E. A. Pigarova ◽  
L. Y. Rozhinskaya ◽  
E. A. Troshina
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Russian Federation ◽  
Large Scale ◽  
Epidemiological Studies ◽  
Cross Sectional ◽  
First Results ◽  
Wide Scale ◽  
The Russian Federation

BACKGROUND. In Russian Federation, there are no large-scale cross-sectional multicenter epidemiological studies assessing the prevalence of vitamin D deficiency and insufficiency in different geographical latitudes. Insufficient solar insolation and inadequate vitamin D content in food dictate the need to study the epidemiological structure of low vitamin D status in Russia.AIM. To assess the incidence of vitamin D deficiency and insufficiency among the population living in the regions of the Russian Federation located at latitudes from 45 ° to 70 °.MATERIALS AND METHODS. The first stage of the Russian multicenter non-interventional registry study using the «crosssectional» method was carried out from March 2020 to May 2020.RESULTS. In regions that represent a geographically representative sample of regions of the Russian Federation with a high risk of developing low levels of vitamin D, it’s deficiency was noted in 55.96%, and the level of deficiency and insufficiency was recorded in 84.01%.CONCLUSION. Close attention to the wide scale of the problem of vitamin D deficiency and insufficiency in the Russian Federation will contribute to the progressive formation of various educational and preventive programs necessary to strengthen health and improve the quality of life of the population.

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