Diagnosis of lung cancer based on direct-infusion electrospray mass spectrometry of blood plasma metabolites

2012 ◽  
Vol 309 ◽  
pp. 200-205 ◽  
Author(s):  
Petr G. Lokhov ◽  
Oleg N. Kharybin ◽  
Alexander I. Archakov
Keyword(s):  
Mass Spectrometry ◽  
Lung Cancer ◽  
Blood Plasma ◽  
Electrospray Mass Spectrometry ◽  
Plasma Metabolites ◽  
Direct Infusion ◽  
Diagnosis Of Lung Cancer

Ambient mass spectrometry for the molecular diagnosis of lung cancer

The Analyst ◽  
2020 ◽  
Vol 145 (2) ◽  
pp. 313-320 ◽  
Author(s):  
Haiyan Lu ◽  
Hua Zhang ◽  
Yiping Wei ◽  
Huanwen Chen
Keyword(s):  
Mass Spectrometry ◽  
Lung Cancer ◽  
Molecular Diagnosis ◽  
Ambient Mass Spectrometry ◽  
Diagnosis Of Lung Cancer ◽  
Improved Accuracy ◽  
Bulk Tissue

Lipids, metabolites and proteins in a bulk tissue were sequentially detected by iEESI-MS for improved accuracy in cancer differentiation.

scholarly journals Use of Direct-Infusion Electrospray Mass Spectrometry To Guide Empirical Development of Improved Conditions for Expression of Secondary Metabolites from Actinomycetes

2001 ◽  
Vol 67 (1) ◽  
pp. 377-386 ◽  
Author(s):  
James A. Zahn ◽  
Richard E. Higgs ◽  
Matthew D. Hilton
Keyword(s):  
Mass Spectrometry ◽  
Solid State ◽  
Secondary Metabolites ◽  
High Performance ◽  
Electrospray Mass Spectrometry ◽  
Solid Phase ◽  
Productivity Index ◽  
Direct Infusion ◽  
Major Barrier ◽  
Fermentation Conditions

ABSTRACT A major barrier in the discovery of new secondary metabolites from microorganisms is the difficulty of distinguishing the minor fraction of productive cultures from the majority of unproductive cultures and growth conditions. In this study, a rapid, direct-infusion electrospray mass spectrometry (ES-MS) technique was used to identify chemical differences that occurred in the expression of secondary metabolites by 44 actinomycetes cultivated under six different fermentation conditions. Samples from actinomycete fermentations were prepared by solid-phase extraction, analyzed by ES-MS, and ranked according to a chemical productivity index based on the total number and relative intensity of ions present in each sample. The actinomycete cultures were tested for chemical productivity following treatments that included nutritional manipulations, autoregulator additions, and different agitation speeds and incubation temperatures. Evaluation of the ES-MS data from submerged and solid-state fermentations by pairedt test analyses showed that solid-state growth significantly altered the chemical profiles of extracts from 75% of the actinomycetes evaluated. Parallel analysis of the same extracts by high-performance liquid chromatography–ES-MS–evaporative light scattering showed that the chemical differences detected by the ES-MS method were associated with growth condition-dependent changes in the yield of secondary metabolites. Our results indicate that the high-throughput ES-MS method is useful for identification of fermentation conditions that enhance expression of secondary metabolites from actinomycetes.

Metabolomic fingerprinting of serum samples based on direct infusion mass spectrometry for lung cancer diagnosis

2017 ◽  
Author(s):  
Byron Enrique Urizar Catalan ◽  
Belén Callejón Leblic ◽  
Victoria Ignacio Barrios ◽  
Eva Vázquez Gandullo ◽  
Rocio Baya Arenas ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Lung Cancer ◽  
Cancer Diagnosis ◽  
Direct Infusion ◽  
Serum Samples ◽  
Direct Infusion Mass Spectrometry ◽  
Lung Cancer Diagnosis ◽  
Metabolomic Fingerprinting

An optimized protocol for metabolome analysis in yeast using direct infusion electrospray mass spectrometry

2003 ◽  
Vol 62 (6) ◽  
pp. 929-937 ◽  
Author(s):  
Juan I Castrillo ◽  
Andrew Hayes ◽  
Shabaz Mohammed ◽  
Simon J Gaskell ◽  
Stephen G Oliver
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Mass Spectrometry ◽  
Direct Infusion ◽  
Metabolome Analysis ◽  
Optimized Protocol

Abstract 1733: Development of a novel blood plasma protein test for diagnosis of lung cancer

2012 ◽  
Author(s):  
Robert T. Streeper ◽  
Elzbieta Izbicka ◽  
Armando Diaz ◽  
David Campos ◽  
Christopher Louden ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Blood Plasma ◽  
Plasma Protein ◽  
Blood Plasma Protein ◽  
Diagnosis Of Lung Cancer

Blood plasma metabolites and the risk of developing lung cancer in Russia

2013 ◽  
Vol 22 (4) ◽  
pp. 335-341 ◽  
Author(s):  
Petr G. Lokhov ◽  
Oxana P. Trifonova ◽  
Dmitry L. Maslov ◽  
Alexander I. Archakov
Keyword(s):  
Lung Cancer ◽  
Blood Plasma ◽  
Plasma Metabolites

Determination of zoledronic acid in human urine and blood plasma using liquid chromatography/electrospray mass spectrometry

2011 ◽  
Vol 879 (22) ◽  
pp. 2073-2080 ◽  
Author(s):  
Katrin Veldboer ◽  
Torsten Vielhaber ◽  
Helmut Ahrens ◽  
Jendrik Hardes ◽  
Arne Streitbürger ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Zoledronic Acid ◽  
Blood Plasma ◽  
Human Urine ◽  
Electrospray Mass Spectrometry
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