scholarly journals Seroprevalence of antibodies to influenza A/H1N1/2009 among transmission risk groups after the second wave in Mexico, by a virus-free ELISA method

2011 ◽  
Vol 15 (11) ◽  
pp. e781-e786 ◽  
Author(s):  
Leticia Elizondo-Montemayor ◽  
Mario M. Alvarez ◽  
Martín Hernández-Torre ◽  
Patricia A. Ugalde-Casas ◽  
Lorena Lam-Franco ◽  
...  
Keyword(s):  
Influenza A ◽  
Risk Groups ◽  
Transmission Risk ◽  
Elisa Method ◽  
Influenza A H1n1 ◽  
Second Wave

scholarly journals Effectiveness of MF59™ Adjuvanted Influenza A(H1N1)pdm09 Vaccine in Risk Groups in the Netherlands

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e63156 ◽  
Author(s):  
Leonoor Wijnans ◽  
Jeanne Dieleman ◽  
Bettie Voordouw ◽  
Miriam Sturkenboom
Keyword(s):  
The Netherlands ◽  
Influenza A ◽  
Risk Groups ◽  
Influenza A H1n1

scholarly journals The use of pharmacological protocols during the Covid-19 crisis - a déjà vu of the 2009 A/H1N1 pandemic experience

2020 ◽  
Vol 3 ◽  
Author(s):  
Wladimir Jimenez Alonso ◽  
Cynthia Schuck-Paim ◽  
Veronique Diez Vicera
Keyword(s):  
Influenza A ◽  
Treatment Options ◽  
Risk Groups ◽  
Time Frame ◽  
Conclusive Evidence ◽  
World Health ◽  
Controlled Trials ◽  
Special Importance ◽  
H1n1 Pandemic ◽  
Influenza A H1n1

Only one decade ago, the World Health Organization declared the outbreak of a novel influenza A (H1N1) virus a worldwide pandemic. Then, just as in today’s Covid-19 crisis, treatment options were the center of debate, one of which is of special importance to the current pandemic: the existence of pharmacological treatments that, although available and potentially effective, are approached with reluctance due to concerns around side effects, the development of resistance and lack of conclusive evidence of effectiveness from randomized-controlled trials. History has proven that reluctance to use antivirals during the 2009 A/H1N1 pandemic was unwise, as those countries that restricted their use to at-risk groups and to patients with advanced disease experienced higher mortality. Those same antiviral are now routinely used for seasonal influenza. We revisit this forgotten lesson as a means of weighing in on the debate over the use of new treatments with promising outcomes as observed in clinical practice, but lacking strong evidence from controlled trials, which require a time frame incompatible with that available in unfolding public health emergencies triggered by novel pathogens.

scholarly journals Specific Recognition of Influenza A/H1N1/2009 Antibodies in Human Serum: A Simple Virus-Free ELISA Method

PLoS ONE ◽  
2010 ◽  
Vol 5 (4) ◽  
pp. e10176 ◽  
Author(s):  
Mario M. Alvarez ◽  
Felipe López-Pacheco ◽  
José M. Aguilar-Yañez ◽  
Roberto Portillo-Lara ◽  
Gonzalo I. Mendoza-Ochoa ◽  
...  
Keyword(s):  
Human Serum ◽  
Influenza A ◽  
Elisa Method ◽  
Specific Recognition ◽  
Influenza A H1n1

scholarly journals Trends in influenza vaccination behaviours – results from the CoPanFlu cohort, France, 2006 to 2011

2013 ◽  
Vol 18 (45) ◽  
Author(s):  
A L Caille-Brillet ◽  
J Raude ◽  
N Lapidus ◽  
X De Lamballerie ◽  
F Carrat ◽  
...  
Keyword(s):  
Risk Factors ◽  
Influenza Vaccination ◽  
Pandemic Influenza ◽  
Influenza A ◽  
Seasonal Influenza ◽  
General Trend ◽  
Vaccine Coverage ◽  
Risk Groups ◽  
Influenza A H1n1 ◽  
Negative Effect

Controversies over the effectiveness and safety of the pandemic influenza A(H1N1)pdm09 vaccine in 2009/10 may have altered the influenza vaccination coverage in France after the pandemic season. The purpose of this study was to determine whether the pandemic affected seasonal influenza vaccination behaviours in the general population by analysing vaccination behaviours from 2006/07 to 2011/12 among the 1,451 subjects of the Cohort for Pandemic Influenza (CoPanFlu) France. We found that vaccination behaviours in 2010/11 and 2011/12 significantly differed from behaviours before the pandemic, with the notable exception of the targeted risk groups for seasonal influenza-related complications. Among the population with no risk factors, the post-pandemic influenza vaccine coverage decreased, with people aged 15 to 24 years and 45 to 64 years being most likely to abandon vaccination. Therefore, this study documents a moderate negative effect of the 2009/10 pandemic episode on vaccination behaviours in the French metropolitan population that was apparent also in the following two seasons. Moreover, it does not exclude that the general trend of reduced vaccination has also affected certain targeted groups at high risk for complications.

scholarly journals Seroprevalence to Influenza A(H1N1) 2009 Virus—Where Are We?

2011 ◽  
Vol 18 (8) ◽  
pp. 1205-1212 ◽  
Author(s):  
Eeva Broberg ◽  
Angus Nicoll ◽  
Andrew Amato-Gauci
Keyword(s):  
Influenza A ◽  
Age Groups ◽  
Risk Groups ◽  
The Elderly ◽  
Current Data ◽  
Lessons Learned ◽  
H1n1 Pandemic ◽  
Influenza A H1n1 ◽  
Before And After ◽  
Vaccination Campaigns

ABSTRACTAge-specific seroprevalences for influenza virus make important contributions to estimating the burden of infection and determining the vulnerable populations. It is especially difficult to know the true clinical attack rates of the 2009 influenza A(H1N1) pandemic; however, we can estimate infection rates through analyses of seroprevalences based on national studies from different continents and countries with different demographics. After the 2009 influenza A(H1N1) pandemic, seroprevalence studies found 5 to 60% of populations across different continents and age groups having antibodies against the A(H1N1) 2009 virus. The seropositivity was highest in children and teenagers (20 to 60%) as well as in the elderly older than 80 years (20 to 40%). Preexisting cross-reactive antibodies against the virus were present mostly in sera of older people (born before 1950) who could have encountered viruses descended from the 1918 pandemic viruses. Experience with the 2009 pandemic indicates how essential early and timely serology data against the emerging virus can be for informing decisions on use of antivirals and vaccination campaigns, especially in regard to risk groups. The objectives of this review were to summarize the current data available on seroprevalence before and after the 2009 influenza A(H1N1) pandemic and the lessons learned for future pandemic preparedness.

scholarly journals Estimating the impact of the 2009 influenza A(H1N1) pandemic on mortality in the elderly in Navarre, Spain

2010 ◽  
Vol 15 (5) ◽  
Author(s):  
J Castilla ◽  
J Etxeberria ◽  
E Ardanaz ◽  
Y Floristán ◽  
R López Escudero ◽  
...  
Keyword(s):  
Pandemic Influenza ◽  
Influenza A ◽  
Excess Mortality ◽  
Seasonal Influenza ◽  
The Elderly ◽  
Significant Excess ◽  
Influenza A H1n1 ◽  
The Mean ◽  
The Impact ◽  
Second Wave

We analysed mortality among people aged 65 years or older in Navarre, Spain in 2009 and compared it with the mean for the same period of time in the previous three years. In the pandemic weeks 24 to 52 2009 we observed 4.9% more deaths than expected (p=0.0268). Excess mortality occurred during the circulation of seasonal influenza (8.0%, p=0.0367) and the first wave of pandemic influenza (9.9%, p=0.0079). In the second wave of pandemic influenza there was a non-significant excess of deaths (5.2%, p=0.1166). Surveillance of laboratory-confirmed severe influenza cases detected only one death in this age group.

scholarly journals Risk groups and other target groups – preliminary ECDC guidance for developing influenza vaccination recommendations for the season 2010-11

2010 ◽  
Vol 15 (12) ◽  
Author(s):  
H Nokleby ◽  
A Nicoll
Keyword(s):  
Influenza Vaccination ◽  
Influenza A ◽  
Seasonal Influenza ◽  
H1n1 Virus ◽  
Risk Groups ◽  
Evidence Based ◽  
Target Groups ◽  
Rigorous Approach ◽  
Vaccination Recommendations ◽  
Influenza A H1n1

Providing guidance on risk and target groups for seasonal influenza immunisation is difficult for the 2010-11 season since there is no experience with the new influenza A(H1N1) virus in its seasonal form. Arguments exist for offering immunisation to people with chronic illness and older people, and also for other risk and target groups including pregnant women. A more rigorous approach is being developed to produce annual evidence-based guidance on risk and target groups for influenza vaccination.

scholarly journals Changing socio-economic and ethnic disparities in influenza/A/H1N1 infection early in the 2009 UK epidemic: a descriptive analysis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
James D. Munday ◽  
Richard Pebody ◽  
Katherine E. Atkins ◽  
Albert Jan van Hoek
Keyword(s):  
Ethnic Minority ◽  
Influenza A ◽  
Minority Groups ◽  
Descriptive Analysis ◽  
Ethnic Disparities ◽  
Transmission Risk ◽  
Suspected Case ◽  
Ethnic Minority Groups ◽  
Asian Ethnicity ◽  
Influenza A H1n1

Abstract Background Higher incidence of and risk of hospitalisation and death from Influenza A(H1N1)pdm09 during the 2009 pandemic was reported in ethnic minority groups in many high-income settings including in the United Kingdom (UK). Many of these studies rely on geographical and temporal aggregation of cases and can be difficult to interpret due to the spatial and temporal factors in outbreak spread. Further, it can be challenging to distinguish between disparities in health outcomes caused by variation in transmission risk or disease severity. Methods We used anonymised laboratory confirmed and suspected case data, classified by ethnicity and deprivation status, to evaluate how disparities in risk between socio-economic and ethnic groups vary over the early stages of the 2009 Influenza A(H1N1)pdm09 epidemic in Birmingham and London, two key cities in the emergence of the UK epidemic. We evaluated the relative risk of infection in key ethnic minority groups and by national and city level deprivation rank. Results We calculated higher incidence in more deprived areas and in people of South Asian ethnicity in both Birmingham and London, although the magnitude of these disparities reduced with time. The clearest disparities existed in school-aged children in Birmingham, where the most deprived fifth of the population was 2.8 times more likely to be infected than the most affluent fifth of the population. Conclusions Our analysis shows that although disparities in reported cases were present in the early phase of the Influenza A(H1N1)pdm09 outbreak in both Birmingham and London, they vary substantially depending on the period over which they are measured. Further, the development of disparities suggest that clustering of social groups play a key part as the outbreak appears to move from one ethnic and socio-demographic group to another. Finally, high incidence and large disparities between children indicate that they may hold an important role in driving inequalities.

scholarly journals The 2018-19 influenza season in Afghanistan: Epidemiology and Virology

2020 ◽  
Author(s):  
Mohammad Nadir Sahak ◽  
Fatima Arifi ◽  
Aspen A Hammond ◽  
Henry J Laurenson-Schafer ◽  
Sayed Ataullah Saeedzai ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Influenza Vaccination ◽  
Influenza A ◽  
Seasonal Influenza ◽  
Risk Groups ◽  
Influenza Surveillance ◽  
Limited Information ◽  
Severe Acute Respiratory Infection ◽  
Influenza A H1n1 ◽  
Hospital Visits

Abstract Objective This paper aims to provide information on epidemiology and virology of seasonal influenza for the 2018-19 season, and build upon limited information for developing influenza vaccination policy for risk groups in Afghanistan. Methods This paper is based on a retrospective analysis of Afghanistan influenza surveillance data, both from influenza-like illness (ILI) and severe acute respiratory infection (SARI) cases during the 2018-19 season. The data for 2018-19 has also been compared to the data of the previous two seasons (2016-2017 and 2017-2018). Results During the 2018-19 season, a total number of 10,604 ILI and 5,261 SARI cases were reported to the national influenza sentinel surveillance system. From week 48 2018 to week 14 2019, a total of 713 ILI specimens were tested for influenza virus, and 10.7% were positive with majority influenza A(H1N1)pdm09 virus (57%). Similarly, a total of 1,004 SARI specimens were tested for influenza virus during this period, and 11% were positive for influenza with the majority caused by influenza A(H1N1) pdm09. Almost two-thirds (62%) of the ILI-influenza positive cases and 46% SARI-influenza positive cases aged less than five years. Also, over 50 years old patient was reported to have the second-highest proportion of SARI associated influenza (30%). Conclusion The findings indicate that the seasonal influenza virus results in considerable hospital visits, admissions, and deaths in Afghanistan. The data from this study will inform and guide policymakers in developing national influenza vaccination policies.

Impact of the 2009 Influenza A (H1N1) Pandemic on Healthcare Workers at a Tertiary Care Center in New York City

2013 ◽  
Vol 34 (8) ◽  
pp. 825-831 ◽  
Author(s):  
Nahid Bhadelia ◽  
Rajiv Sonti ◽  
Jennifer Wright McCarthy ◽  
Jaclyn Vorenkamp ◽  
Haomiao Jia ◽  
...  
Keyword(s):  
New York ◽  
New York City ◽  
York City ◽  
Healthcare Workers ◽  
Influenza A ◽  
Care Center ◽  
Tertiary Care ◽  
Tertiary Care Center ◽  
Influenza A H1n1 ◽  
Second Wave

Background and Objective.Assessing the impact of 2009 influenza A (H1N1) on healthcare workers (HCWs) is important for pandemic planning.Methods.We retrospectively analyzed employee health records of HCWs at a tertiary care center in New York City with influenza-like illnesses (ILI) and confirmed influenza from March 31, 2009, to February 28, 2010. We evaluated HCWs' clinical presentations during the first and second wave of the pandemic, staff absenteeism, exposures among HCWs, and association between high-risk occupational exposures to respiratory secretions and infection.Results.During the pandemic, 40% (141/352) of HCWs with ILI tested positive for influenza, representing a 1% attack rate among our 13,066 employees. HCWs with influenza were more likely to have fever, cough, and tachycardia. When compared with the second wave, cases in the first wave were sicker and at higher risk of exposure to patients' respiratory secretions (P = .049). HCWs with ILI- with and without confirmed influenza-missed on average 4.7 and 2.7 work days, respectively (P = .001). Among HCWs asked about working while ill, 65% (153/235) reported they did so (mean, 2 days).Conclusions.HCWs in the first wave had more severe ILI than those in the second wave and were more likely to be exposed to patients' respiratory secretions. HCWs with ILI often worked while ill. Timely strategies to educate and support HCWs were critical to managing this population during the pandemic.

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