scholarly journals Magnesium sulphate induces preconditioning in preterm rodent models of cerebral hypoxia‐ischemia

2018 ◽  
Vol 70 (1) ◽  
pp. 56-66 ◽  
Author(s):  
Gabriella Koning ◽  
Ellinor Lyngfelt ◽  
Pernilla Svedin ◽  
Anna‐Lena Leverin ◽  
Masako Jinnai ◽  
...  
Keyword(s):  
Magnesium Sulphate ◽  
Cerebral Hypoxia ◽  
Rodent Models ◽  
Hypoxia Ischemia

scholarly journals n‐3 Fatty Acids Are Neuroprotective After Cerebral Hypoxia‐Ischemia In Rodent Models

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
JILL J WILLIAMS ◽  
Nicolas Bazan ◽  
Vadim S Ten ◽  
Susan J Vannucci ◽  
Christopher Mastropietro ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Cerebral Hypoxia ◽  
Rodent Models ◽  
Hypoxia Ischemia

scholarly journals Evaluation of 2-[18F]fluoroacetate Kinetics in Rodent Models of Cerebral Hypoxia–Ischemia

2014 ◽  
Vol 34 (5) ◽  
pp. 836-844 ◽  
Author(s):  
Yu Ouyang ◽  
Jeff N Tinianow ◽  
Simon R Cherry ◽  
Jan Marik
Keyword(s):  
Whole Blood ◽  
Tricarboxylic Acid Cycle ◽  
Input Function ◽  
Cerebral Hypoxia ◽  
Rodent Models ◽  
Function Estimation ◽  
Hypoxia Ischemia ◽  
Elevated Lesion ◽  
Necessary And Sufficient

Glia account for 90% of human brain cells and have a significant role in brain homeostasis. Thus, specific in vivo imaging markers of glial metabolism are potentially valuable. In the brain, 2-fluoroacetate is selectively taken up by glial cells and becomes metabolically trapped in the tricarboxylic acid cycle. Recent work in rodent brain injury models demonstrated elevated lesion uptake of 2-[18F]fluoroacetate ([18F]FACE), suggesting possible use for specifically imaging glial metabolism. To assess this hypothesis, we evaluated [18F]FACE kinetics in rodent models of cerebral hypoxia-ischemia at 3 and 24 hours post insult. Lesion uptake was significantly higher at 30 minutes post injection ( P<0.05). An image-based method for input function estimation using cardiac blood was validated. Analysis of whole blood showed no significant metabolites and plasma activity concentrations of ˜50% that of whole blood. Kinetic models describing [18F]FACE uptake were developed and quantitatively compared. Elevated [18F]FACE uptake was found to be driven primarily by K1/k2 rather than k3, but changes in the latter were detectable. The two-tissue irreversible uptake model (2T3k) was found to be necessary and sufficient for modeling [18F]FACE uptake. We conclude that kinetic modeling of [18F]FACE uptake represents a potentially useful tool for interrogation of glial metabolism.

scholarly journals Therapeutic Benefits of Delayed Lithium Administration in the Neonatal Rat after Cerebral Hypoxia-Ischemia

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e107192 ◽  
Author(s):  
Cuicui Xie ◽  
Kai Zhou ◽  
Xiaoyang Wang ◽  
Klas Blomgren ◽  
Changlian Zhu
Keyword(s):  
Neonatal Rat ◽  
Cerebral Hypoxia ◽  
Therapeutic Benefits ◽  
Hypoxia Ischemia

Cerebral hypoxia-ischemia and middle cerebral artery occlusion induce expression of the cannabinoid CB2 receptor in the brain

2007 ◽  
Vol 412 (2) ◽  
pp. 114-117 ◽  
Author(s):  
John C. Ashton ◽  
Rosanna M.A. Rahman ◽  
Shiva M. Nair ◽  
Brad A. Sutherland ◽  
Michelle Glass ◽  
...  
Keyword(s):  
Middle Cerebral Artery ◽  
Middle Cerebral Artery Occlusion ◽  
Cerebral Artery ◽  
Artery Occlusion ◽  
Cerebral Hypoxia ◽  
Cb2 Receptor ◽  
Hypoxia Ischemia ◽  
Cerebral Artery Occlusion ◽  
The Brain

scholarly journals NMNAT3 is protective against the effects of neonatal cerebral hypoxia-ischemia

2017 ◽  
Vol 4 (10) ◽  
pp. 722-738 ◽  
Author(s):  
Rafael Galindo ◽  
Marianne Banks Greenberg ◽  
Toshiyuki Araki ◽  
Yo Sasaki ◽  
Nehali Mehta ◽  
...  
Keyword(s):  
Cerebral Hypoxia ◽  
Hypoxia Ischemia

Detection of Free Radicals in Cerebral Tissue and their Relation to Cerebral Hypoxia/Ischemia

1988 ◽  
pp. 321-335
Author(s):  
Shigeki Imaizumi ◽  
Teiji Tominaga ◽  
Hiroshi Uenohara ◽  
Hiroyuki Kinouchi ◽  
Takashi Yoshimoto ◽  
...  
Keyword(s):  
Free Radicals ◽  
Cerebral Hypoxia ◽  
Cerebral Tissue ◽  
Hypoxia Ischemia

Neuroprotective Effect of Long-term MgSO4 Administration After Cerebral Hypoxia-Ischemia in Newborn Rats Is Related to the Severity of Brain Damage

2007 ◽  
Vol 14 (7) ◽  
pp. 667-677 ◽  
Author(s):  
Evangelia Spandou ◽  
Vassiliki Soubasi ◽  
Stamatia Papoutsopoulou ◽  
Persefoni Augoustides-Savvopoulou ◽  
Theodoros Loizidis ◽  
...  
Keyword(s):  
Brain Damage ◽  
Neuroprotective Effect ◽  
Cerebral Hypoxia ◽  
Newborn Rats ◽  
Hypoxia Ischemia
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