MiR‐194 is involved in morphogenesis of spiral ganglion neurons in inner ear by rearranging actin cytoskeleton via targeting RhoB

2017 ◽  
Vol 63 (1) ◽  
pp. 16-26 ◽  
Author(s):  
Jintao Du ◽  
Xuemei Zhang ◽  
Hui Cao ◽  
Di Jiang ◽  
Xianren Wang ◽  
...  
Keyword(s):  
Actin Cytoskeleton ◽  
Inner Ear ◽  
Spiral Ganglion ◽  
Spiral Ganglion Neurons ◽  
Ganglion Neurons

Substance P inhibits potassium and calcium currents in inner ear spiral ganglion neurons

2004 ◽  
Vol 1012 (1-2) ◽  
pp. 82-92 ◽  
Author(s):  
Wei Sun ◽  
Da-Lian Ding ◽  
Ping Wang ◽  
Jianhe Sun ◽  
Xiaojie Jin ◽  
...  
Keyword(s):  
Substance P ◽  
Inner Ear ◽  
Spiral Ganglion ◽  
Calcium Currents ◽  
Spiral Ganglion Neurons ◽  
Ganglion Neurons

scholarly journals ROR1 is essential for proper innervation of auditory hair cells and hearing in humans and mice

2016 ◽  
Vol 113 (21) ◽  
pp. 5993-5998 ◽  
Author(s):  
Oscar Diaz-Horta ◽  
Clemer Abad ◽  
Levent Sennaroglu ◽  
Joseph Foster ◽  
Alexandra DeSmidt ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Inner Ear ◽  
Hair Cells ◽  
Spiral Ganglion ◽  
Auditory Neuropathy ◽  
Mutant Mice ◽  
Spiral Ganglion Neurons ◽  
Type I ◽  
Auditory Hair Cells ◽  
Ganglion Neurons

Hair cells of the inner ear, the mechanosensory receptors, convert sound waves into neural signals that are passed to the brain via the auditory nerve. Little is known about the molecular mechanisms that govern the development of hair cell–neuronal connections. We ascertained a family with autosomal recessive deafness associated with a common cavity inner ear malformation and auditory neuropathy. Via whole-exome sequencing, we identified a variant (c.2207G>C, p.R736T) in ROR1 (receptor tyrosine kinase-like orphan receptor 1), cosegregating with deafness in the family and absent in ethnicity-matched controls. ROR1 is a tyrosine kinase-like receptor localized at the plasma membrane. At the cellular level, the mutation prevents the protein from reaching the cellular membrane. In the presence of WNT5A, a known ROR1 ligand, the mutated ROR1 fails to activate NF-κB. Ror1 is expressed in the inner ear during development at embryonic and postnatal stages. We demonstrate that Ror1 mutant mice are severely deaf, with preserved otoacoustic emissions. Anatomically, mutant mice display malformed cochleae. Axons of spiral ganglion neurons show fasciculation defects. Type I neurons show impaired synapses with inner hair cells, and type II neurons display aberrant projections through the cochlear sensory epithelium. We conclude that Ror1 is crucial for spiral ganglion neurons to innervate auditory hair cells. Impairment of ROR1 function largely affects development of the inner ear and hearing in humans and mice.

scholarly journals Inhibition of MMP-2 but not MMP-9 Influences Inner Ear Spiral Ganglion Neurons In Vitro

2014 ◽  
Vol 34 (7) ◽  
pp. 1011-1021 ◽  
Author(s):  
Michael Sung ◽  
Eric Wei ◽  
Eduardo Chavez ◽  
Neha Jain ◽  
Soledad Levano ◽  
...  
Keyword(s):  
Inner Ear ◽  
Spiral Ganglion ◽  
Spiral Ganglion Neurons ◽  
Ganglion Neurons
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