scholarly journals Suboptimal maternal diets alter mu opioid receptor and dopamine type 1 receptor binding but exert no effect on dopamine transporters in the offspring brain

2016 ◽  
Vol 64 (1) ◽  
pp. 21-28 ◽  
Author(s):  
Panayotis K. Thanos ◽  
Jianmin Zhuo ◽  
Lisa Robison ◽  
Ronald Kim ◽  
Mala Ananth ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Receptor Binding ◽  
Mu Opioid Receptor ◽  
Dopamine Transporters ◽  
Mu Opioid

Opioid receptors in the accessory optic system of the rat: Effects of monocular enucleation

1990 ◽  
Vol 5 (5) ◽  
pp. 497-506 ◽  
Author(s):  
R.A. Giolli ◽  
R.H.I. Blanks ◽  
Y. Torigoe ◽  
R.J. Clarke ◽  
J.H. Fallon ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Opioid Receptors ◽  
Receptor Binding ◽  
Mu Opioid Receptor ◽  
Mu Opioid Receptors ◽  
Mu Opioid ◽  
Mu Receptor ◽  
Monocular Enucleation ◽  
Mu Receptors ◽  
Opioid Receptor Binding

AbstractThe presence and concentrations of each of the three subtypes of opioid receptors (mu, kappa, and delta) has been studied in the accessory optic nuclei (dorsal, lateral, and medial terminal nuclei and the interstitial nucleus of the superior fasciculus, posterior fibers: DTN, LTN, MTN, and inSFp) in normal young rats with radioligands directed towards each opioid receptor subtype. The changes in mu opioid receptors have also been investigated in monocularly enucleated rats in which one eye was removed and the rats sacrificed at postoperative day (PO) 2, 3, 5, 7, 14, and 30. As the MTN is the only accessory optic nucleus of the rat large enough for semiquantitative evaluation, the mu receptor population of the MTN has been subjected to optical microdensitometric analysis.All four of the accessory optic nuclei (AOS nuclei) are found to contain exceedingly high levels of mu opioid receptor binding with the selective radioligand [3H]-[D-Ala, MePhe4, Gly-ol5] (DAGO), low levels of kappa opioid receptor binding using the radioligand [3H]-[ethylketocyclazocine] (EKC) together with the competing agents [D-Pro4]-morphiceptin and [D-Ser2, Thr6]-Leu-enkephalin, and an absence of delta opioid receptor binding with the radioligand [3H]-[D-A1a2, D-Leu5]-enkephalin (DADLE) combined with the competing agent [D-Pro4]-morphiceptin. Monocular enucleation, as studied on the mu opioid receptor population with this experimental approach, results in virtually a complete loss of mu opioid receptors throughout all four of the contralaterally located AOS nuclei, including both dorsal and ventral subdivisions of the medial terminal nucleus (MTNd, v). Kappa and delta receptors are very few (kappa receptors) or are lacking (delta receptors) in the AOS nuclei, and for this reason, the effects of monocular enucleation on these two opioid receptor subtypes have not been investigated. Monocular enucleation also produces a significant lowering in mu receptor binding in other primary optic nuclei (the lateral geniculate nuclei, nucleus of the optic tract, and superficial layers of the superior colliculus) and in the pars principalis of the medial geniculate nucleus (description of changes in mu receptors in non-accessory optic primary optic nuclei will be considered elsewhere).Microdensitometric study of the MTNd, v shows that the decreased binding of mu receptors in this nucleus is barely detectable (about 6%) at PO2 and rises to 6–15% at PO3. At PO5 receptor loss reaches approximately 62%, whereas at PO7 it is about 81% complete. At PO14 and PO30, the mu receptor loss is nearly complete at around 93%. Mu receptor loss involves all of the AOS nuclei contralateral, but none ipsilateral, to ocular enucleation, an observation entirely consistent with the overwhelmingly crossed (about 97%) nature of the retinofugal projection to the rat accessory optic nuclei. These opioid receptors represent a prominent feature in the AOS and other primary optic nuclei of the rat. Their role in visuomotor control remains uncertain but probably involves the fine-tuning of information concerned with compensatory eye movements.

Association between GCH1 SNPs and mu-opioid receptor binding potential in healthy participants

2010 ◽  
Vol 11 (4) ◽  
pp. S30
Author(s):  
C. Campbell ◽  
H. Kuwabara ◽  
M. Simango ◽  
J. Campbell ◽  
J. Haythornthwaite ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Receptor Binding ◽  
Mu Opioid Receptor ◽  
Binding Potential ◽  
Mu Opioid ◽  
Healthy Participants ◽  
Opioid Receptor Binding

Cannabinoid Receptor Type 1 and mu-Opioid Receptor Polymorphisms Are Associated With Cyclic Vomiting Syndrome

2017 ◽  
Vol 112 (6) ◽  
pp. 933-939 ◽  
Author(s):  
Andrzej Wasilewski ◽  
Urszula Lewandowska ◽  
Paula Mosinska ◽  
Cezary Watala ◽  
Martin Storr ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Cannabinoid Receptor ◽  
Mu Opioid Receptor ◽  
Receptor Type ◽  
Cyclic Vomiting Syndrome ◽  
Mu Opioid ◽  
Cannabinoid Receptor Type 1 ◽  
Cyclic Vomiting

Chronic opioid antagonist administration upregulates mu opioid receptor binding without altering mu opioid receptor mRNA levels

1995 ◽  
Vol 33 (2) ◽  
pp. 351-355 ◽  
Author(s):  
Ellen M. Unterwald ◽  
Joshua M. Rubenfeld ◽  
Yasuo Imai ◽  
Jia-Bei Wang ◽  
George R. Uhl ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Receptor Binding ◽  
Mu Opioid Receptor ◽  
Opioid Antagonist ◽  
Mrna Levels ◽  
Mu Opioid ◽  
Receptor Mrna ◽  
Opioid Receptor Binding

scholarly journals Mu Opioid Receptor Binding Correlates with Nicotine Dependence and Reward in Smokers

PLoS ONE ◽  
2014 ◽  
Vol 9 (12) ◽  
pp. e113694 ◽  
Author(s):  
Hiroto Kuwabara ◽  
Stephen J. Heishman ◽  
James R. Brasic ◽  
Carlo Contoreggi ◽  
Nicola Cascella ◽  
...  
Keyword(s):  
Nicotine Dependence ◽  
Opioid Receptor ◽  
Receptor Binding ◽  
Mu Opioid Receptor ◽  
Mu Opioid ◽  
Opioid Receptor Binding

scholarly journals Acute systemic administration of morphine selectively increases mu opioid receptor binding in the rat brain

Neuropeptides ◽  
1984 ◽  
Vol 5 (1-3) ◽  
pp. 117-120 ◽  
Author(s):  
James W. Lewis ◽  
Michael E. Lewis ◽  
Deborah J. Loomus ◽  
Huda Akil
Keyword(s):  
Rat Brain ◽  
Opioid Receptor ◽  
Receptor Binding ◽  
Mu Opioid Receptor ◽  
Systemic Administration ◽  
Mu Opioid ◽  
Opioid Receptor Binding
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