Prenatal undernutrition increases the febrile response to lipopolysaccharides in adulthood in male rats

2015 ◽  
Vol 44 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Takeshi Iwasa ◽  
Toshiya Matsuzaki ◽  
Altankhuu Tungalagsuvd ◽  
Munkhsaikhan Munkhzaya ◽  
Akira Kuwahara ◽  
...  
Keyword(s):  
Male Rats ◽  
Febrile Response ◽  
Prenatal Undernutrition

scholarly journals Prenatal undernutrition disrupted the sexual maturation, but not the sexual behavior, in male rats

2017 ◽  
Vol 16 (4) ◽  
pp. 325-329 ◽  
Author(s):  
Toshiya Matsuzaki ◽  
Munkhsaikhan Munkhzaya ◽  
Altankhuu Tungalagsuvd ◽  
Yiliyasi Mayila ◽  
Takeshi Iwasa ◽  
...  
Keyword(s):  
Sexual Behavior ◽  
Sexual Maturation ◽  
Male Rats ◽  
Prenatal Undernutrition

scholarly journals “Biphasic” fevers often consist of more than two phases

1998 ◽  
Vol 275 (1) ◽  
pp. R323-R331 ◽  
Author(s):  
Andrej A. Romanovsky ◽  
Christopher T. Simons ◽  
Vladimir A. Kulchitsky
Keyword(s):  
Phase Plane ◽  
Rate Of Change ◽  
Male Rats ◽  
Saline Control ◽  
Common Belief ◽  
Febrile Response ◽  
E Coli ◽  
General Law ◽  
Triphasic Pattern ◽  
Phenol Extract

This paper disproves the common belief that all doses of lipopolysaccharide (LPS) that are commonly referred to as biphasic fever inducing (≥2 μg/kg) cause truly biphasic responses. A catheter was implanted into the right jugular vein of several strains of adult male rats, and the animals were habituated to the experimental conditions. At an ambient temperature of 30.0°C, loosely restrained animals were injected with a 10 μg/kg dose of LPS (various preparations), and their colonic (Tc) and tail skin temperatures were monitored (from ≥1 h before to ≥7 h after the injection). The results are presented as time graphs and phase-plane plots; in the latter case the rate of change of Tc is plotted against Tc. In experiment 1 the intravenous injection of LPS (from Escherichia coli 0111:B4, phenol extract) into the rats (Bkl:Wistar) induced a triphasic febrile response, as is obvious from time graphs of Tc (3 peaks), time graphs of effector activity (3 waves of tail skin vasoconstriction), and phase-plane plots (3 complete loops); the injection of saline (control) induced no Tc changes. We analyzed whether the triphasic pattern was due to some peculiarities of the experimental design, i.e., the pyrogen preparation used ( experiment 2) or the rat strain tested ( experiment 3) or whether this pattern reflects a more general law. In experiment 2 we used the same (phenol) preparation of different LPS (from Shigella flexneri 1A and Salmonella typhosa) and a different preparation (TCA extract) of the same LPS ( E. coli). Regardless of the LPS used, rats of the Bkl:Wistar strain responded to the 10 μg/kg dose with the triphasic fever. In experiment 3, rats of other strains [Bkl:Sprague-Dawley and Sim:(LE)fBR(Black-hooded)] were tested. Again, all animals responded to the 10 μg/kg dose of E. coli LPS (phenol extract) with the triphasic fever. Because all fevers caused by four different LPS preparations in three rat strains were triphasic, the triphasic pattern is likely to constitute an intrinsic characteristic of the febrile response.

Fever in rats during normal and dehydrated conditions

1986 ◽  
Vol 61 (6) ◽  
pp. 2060-2066 ◽  
Author(s):  
A. Morimoto ◽  
T. Ono ◽  
T. Watanabe ◽  
N. Murakami
Keyword(s):  
Intravenous Injection ◽  
The Other ◽  
Female Rats ◽  
Male Rats ◽  
Normal Female ◽  
Endogenous Pyrogen ◽  
Febrile Response ◽  
Physiological Mechanisms ◽  
Intravenous Injections ◽  
Biphasic Pattern

The effect of endogenous pyrogen (EP, from rabbit) and endotoxin (Salmonella typhosa) on rectal temperature (Tre) was investigated in normal and dehydrated rats of both sexes. Intraperitoneal injection of either EP or endotoxin did not affect body temperature. In addition, no changes in Tre were observed when endotoxin was injected intravenously in normally hydrated male rats, but significant falls in Tre occurred in normal female rats. However, intravenous injection of EP produced fever in both sexes, but females generally showed smaller responses. A second intravenous injection of endotoxin, given 3 days after the first injection, always produced fever in normally hydrated rats. The pattern of this febrile response was monophasic. In contrast to the response in normal rats, intravenous endotoxin produced significant fevers with a biphasic pattern in dehydrated rats of either sex, but the febrile responses of male rats were greater than those of female rats. On the other hand, there were no significant differences between febrile responses to intravenous EP exhibited by normal and dehydrated animals. These results show that rats of both sexes possess physiological mechanisms capable of producing a fever following intravenous injections of EP.

Prenatal undernutrition decreases the anorectic response to septic doses of lipopolysaccharides in adulthood in male rats

2018 ◽  
Vol 69 (1) ◽  
pp. 39-43
Author(s):  
Takeshi Iwasa ◽  
Toshiya Matsuzaki ◽  
Kiyohito Yano ◽  
Yiliyasi Mayila ◽  
Minoru Irahara
Keyword(s):  
Male Rats ◽  
Prenatal Undernutrition

Vagal CCK and 5-HT3receptors are unlikely to mediate LPS or IL-1β-induced fever

2000 ◽  
Vol 279 (3) ◽  
pp. R960-R965 ◽  
Author(s):  
S. M. Martin ◽  
B. C. Wilson ◽  
X. Chen ◽  
Y. Takahashi ◽  
P. Poulin ◽  
...  
Keyword(s):  
Body Temperature ◽  
Vagus Nerve ◽  
Adult Male ◽  
Vagal Afferents ◽  
Interleukin 1Β ◽  
Male Rats ◽  
Febrile Response ◽  
Immune Mediators ◽  
Data Support

Previous studies suggested that peripheral immune mediators may involve intermediates acting on the vagus nerve, such as CCK or serotonin (5-HT). We have therefore investigated a possible role for vagal CCK-A and 5-HT3receptors in the febrile response after intraperitoneal human recombinant interleukin-1β (IL-1β) or lipopolysaccharide (LPS). Unanesthetized, adult male rats instrumented with abdominal thermistors were given intraperitoneal CCK-8 sulfate (100 or 150 μg/kg) or 2-methyl-5-hydroxytryptamine maleate (4 mg/kg). In other experiments, rats were treated with either antagonists to the 5-HT3 receptor (ondansetron HCl; 100 μg/kg) or the CCK-A receptor (L-364,718, 100 or 200 μg/kg) in combination with LPS or IL-1β. CCK administration caused a short-lived hypothermia, but interference with the action of endogenous CCK at CCK-A receptors was without effect on IL-1β- or LPS-induced fever. Neither activation of 5-HT3 receptors nor blockade of 5-HT3 receptors affected body temperature or LPS fever. Taken together, our data support the idea that vagal afferents responsive to pyrogenic cytokines may be different from those responsive to CCK or 5-HT.

Interleukin-1 receptor antagonist as a modulator of gender differences in the febrile response to lipopolysaccharide in rats

2007 ◽  
Vol 292 (4) ◽  
pp. R1667-R1674 ◽  
Author(s):  
H. Ashdown ◽  
S. Poole ◽  
P. Boksa ◽  
G. N. Luheshi
Keyword(s):  
Receptor Antagonist ◽  
Plasma Levels ◽  
Physiological State ◽  
Interleukin 1 ◽  
Female Rats ◽  
Male Rats ◽  
Mrna Levels ◽  
Febrile Response ◽  
Interleukin 1 Receptor Antagonist ◽  
Near Term

Febrile responses to bacterial pathogens are attenuated near term of pregnancy in several mammalian species. It is unknown, however, whether this reflects a fundamental physiological adaptation of female rats or whether it is specific to pregnancy. The aims of this study therefore were 1) to determine whether febrile responses to the bacterial endotoxin lipopolysaccharide (LPS) are attenuated in female vs. male rats and, if so, to identify possible mechanisms involved in modulating this and 2) to assess whether plasma concentrations of the anti-inflammatory cytokine, interleukin-1 receptor antagonist (IL-1ra), an important regulator of fever, are dependent on the physiological state of the female and could therefore be involved in modulating febrile responses. We found febrile responses were attenuated in cycling female vs. male rats and also in near-term pregnant dams vs. cycling females after intraperitoneal injection of LPS (0.05 mg/kg). Plasma levels of IL-1ra were significantly greater in female rats after injection of LPS, particularly during pregnancy, than in males. This was accompanied by attenuated levels of hypothalamic IL-1β and cyclooxygenase-2 mRNA, two key mediators of the febrile response, in female rats. Furthermore, increasing plasma levels of IL-1ra in male rats by intraperitoneal administration of the recombinant antagonist attenuated hypothalamic mRNA levels of these mediators after LPS. These data suggest that there is a fundamental difference in febrile response to LPS between the genders that is likely regulated by IL-1ra. This may be an important mechanism that protects the developing fetus from potentially deleterious consequences of maternal fever during pregnancy.

scholarly journals Castration fails to prevent prenatally programmed hypertension in male rats

2010 ◽  
Vol 298 (4) ◽  
pp. R1111-R1116 ◽  
Author(s):  
Lori L. Woods ◽  
Terry K. Morgan ◽  
John A. Resko
Keyword(s):  
Blood Pressure ◽  
Renal Plasma Flow ◽  
Female Offspring ◽  
Male Offspring ◽  
Male Rats ◽  
Baseline Blood Pressure ◽  
Intact Male ◽  
Protein Excretion ◽  
Prenatal Undernutrition

Male offspring of rats that were modestly protein restricted during pregnancy become hypertensive as adults, whereas their female littermates remain normotensive. The purpose of this study was to determine the role of testosterone in promoting this sexual dimorphism of prenatally programmed hypertension. Rats were fed either a normal (19% protein, NP) or modestly protein-restricted (8.5% protein, LP) diet throughout pregnancy. Male offspring either remained intact or were castrated (CAS) at 30 days of age. Female offspring remained intact. At ∼22 wk of age, the offspring were chronically instrumented for measurement of mean arterial pressure and renal function. Intact male LP offspring were hypertensive compared with male NP offspring (138 ± 2 vs. 130 ± 2 mmHg, P < 0.007), whereas female LP offspring were normotensive (123 ± 1 vs. 122 ± 2 mmHg in NP females). In CAS males, blood pressure in both diet groups was not different from that in intact males of the same group (138 ± 3 mmHg in LP CAS males, and 131 ± 2 mmHg in NP CAS males). Glomerular filtration rate and effective renal plasma flow were also not significantly affected by castration. However, castration significantly reduced protein excretion in LP males to levels not different from those in NP CAS and intact males. Renal histopathology scores showed a similar pattern. Thus removal of androgens by castration failed to provide any protective effect against the hypertension programmed by maternal protein restriction. Castration also failed to abolish the sex difference in blood pressure in both diet groups. These findings suggest that the lifelong presence of normal levels of testicular hormones does not play a major role either in maintaining baseline blood pressure higher in males than in females, or in promoting further elevations in blood pressure in males due to prenatal undernutrition. However, androgens such as testosterone may promote renal injury in LP males.

Influence of prenatal undernutrition on the effects of clozapine and aripiprazole in the adult male rats: Relevance to a neurodevelopmental origin of schizophrenia?

2011 ◽  
Vol 667 (1-3) ◽  
pp. 402-409 ◽  
Author(s):  
Johann Guillemot ◽  
Marie-Amélie Lukaszewski ◽  
Valérie Montel ◽  
Fabien Delahaye ◽  
Sylvain Mayeur ◽  
...  
Keyword(s):  
Adult Male ◽  
Male Rats ◽  
Prenatal Undernutrition

Prenatal undernutrition attenuates fasting‐induced reproductive dysfunction in pre‐pubertal male rats

2018 ◽  
Vol 71 (1) ◽  
pp. 30-33 ◽  
Author(s):  
Takeshi Iwasa ◽  
Toshiya Matsuzaki ◽  
Kiyohito Yano ◽  
Yiliyasi Mayila ◽  
Minoru Irahara
Keyword(s):  
Male Rats ◽  
Reproductive Dysfunction ◽  
Prenatal Undernutrition
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