The effects of hypoxic preconditioning on white matter damage following hypoxic‐ischaemic injury in the neonatal rat brain

2014 ◽  
Vol 37 (1) ◽  
pp. 69-75 ◽  
Author(s):  
Eurwin Suryana ◽  
Nicole M. Jones
Keyword(s):  
White Matter ◽  
Rat Brain ◽  
Hypoxic Preconditioning ◽  
Neonatal Rat ◽  
White Matter Damage ◽  
Ischaemic Injury ◽  
Neonatal Rat Brain

scholarly journals 17β-estradiol protects against hypoxic/ischemic white matter damage in the neonatal rat brain

2009 ◽  
Vol 87 (9) ◽  
pp. 2078-2086 ◽  
Author(s):  
Bettina Gerstner ◽  
Joan Lee ◽  
Tara M. DeSilva ◽  
Frances E. Jensen ◽  
Joseph J. Volpe ◽  
...  
Keyword(s):  
White Matter ◽  
Rat Brain ◽  
Neonatal Rat ◽  
White Matter Damage ◽  
17Β Estradiol ◽  
Neonatal Rat Brain

Expression of SIRT3 in various glial cell types in the periventricular white matter in the neonatal rat brain after hypoxia

2018 ◽  
Vol 52 ◽  
pp. 1-8 ◽  
Author(s):  
Xiu-Hua Li ◽  
Shun-Jin Liu ◽  
Xiao-Yu Liu ◽  
Hai-Yu Zhao ◽  
Mao-Geng Yang ◽  
...  
Keyword(s):  
White Matter ◽  
Rat Brain ◽  
Glial Cell ◽  
Cell Types ◽  
Neonatal Rat ◽  
Periventricular White Matter ◽  
Neonatal Rat Brain

scholarly journals Hypoxic Preconditioning Induces Changes in HIF-1 Target Genes in Neonatal Rat Brain

2001 ◽  
Vol 21 (9) ◽  
pp. 1105-1114 ◽  
Author(s):  
Nicole M. Jones ◽  
Marcelle Bergeron
Keyword(s):  
Gene Expression ◽  
Rat Brain ◽  
Target Genes ◽  
Hypoxia Inducible Factor ◽  
Hypoxic Preconditioning ◽  
Neonatal Rat ◽  
Glucose Transporter 1 ◽  
Glut 1 ◽  
Hypoxia Inducible Factor 1 ◽  
Neonatal Rat Brain

Hypoxic preconditioning induces tolerance to hypoxic-ischemic injury in neonatal rat brain and is associated with changes in gene expression. Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that is strongly induced by hypoxia or the hypoxia-mimetic compound cobalt chloride (CoCl2). Hypoxia-inducible factor-1 modulates the expression of several target genes including the glycolytic enzymes, glucose transporter-1 (GLUT-1), and erythropoietin. Recently, HIF-1 expression was shown to increase after hypoxic and CoCl2 preconditioning in newborn rat brain. To study the involvement of HIF-1 target genes in neonatal hypoxia-induced ischemic tolerance, the authors examined the brains of newborn rats after exposure to hypoxia (8% O2 for 3 hours) or injection of CoCl2 (60 mg/kg). Preconditioning with hypoxia or CoCl2 24 hours before hypoxia-ischemia afforded a 96% and 76% brain protection, respectively, compared with littermate control animals. Hypoxic preconditioning increased the expression of GLUT-1 mRNA and protein, and of aldolase, phosphofructokinase, and lactate dehydrogenase proteins but not mRNA. This suggests that the modulation of glucose transport and glycolysis by hypoxia may contribute to the development of hypoxia-induced tolerance. In contrast, preconditioning with CoCl2 did not produce any change in HIF-1 target gene expression suggesting that different molecular mechanisms may be involved in the induction of tolerance by hypoxia and CoCl2 in newborn brain.

α-Phenyl-n-tert-butyl-nitrone reduces lipopolysaccharide-induced white matter injury in the neonatal rat brain

2008 ◽  
Vol 68 (3) ◽  
pp. 365-378 ◽  
Author(s):  
Lir-Wan Fan ◽  
Helen J. Mitchell ◽  
Lu-Tai Tien ◽  
Baoying Zheng ◽  
Yi Pang ◽  
...  
Keyword(s):  
White Matter ◽  
Rat Brain ◽  
White Matter Injury ◽  
Neonatal Rat ◽  
Tert Butyl ◽  
Neonatal Rat Brain
Sign in / Sign up

Export Citation Format

Share Document