Effects of prenatal chronic mild stress exposure on hippocampal cell proliferation, expression of GSK‐3α, β and NR2B in adult offspring during fear extinction in rats

2014 ◽  
Vol 35 (1) ◽  
pp. 16-24 ◽  
Author(s):  
Min Li ◽  
Xiaobai Li ◽  
Xinxin Zhang ◽  
Jintao Ren ◽  
Han Jiang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Chronic Mild Stress ◽  
Fear Extinction ◽  
Adult Offspring ◽  
Mild Stress ◽  
Stress Exposure ◽  
Hippocampal Cell

Maternal trans fat intake during pregnancy or lactation impairs memory and alters BDNF and TrkB levels in the hippocampus of adult offspring exposed to chronic mild stress

2017 ◽  
Vol 169 ◽  
pp. 114-123 ◽  
Author(s):  
Camila Simonetti Pase ◽  
Karine Roversi ◽  
Katiane Roversi ◽  
Luciana Taschetto Vey ◽  
Verônica Tironi Dias ◽  
...  
Keyword(s):  
Chronic Mild Stress ◽  
Adult Offspring ◽  
Mild Stress ◽  
Fat Intake ◽  
Trans Fat

Hippocampal low-frequency stimulation and chronic mild stress similarly disrupt fear extinction memory in rats

2008 ◽  
Vol 89 (4) ◽  
pp. 560-566 ◽  
Author(s):  
René Garcia ◽  
Guillaume Spennato ◽  
Linda Nilsson-Todd ◽  
Jean-Luc Moreau ◽  
Olivier Deschaux
Keyword(s):  
Low Frequency ◽  
Chronic Mild Stress ◽  
Fear Extinction ◽  
Mild Stress ◽  
Low Frequency Stimulation ◽  
Frequency Stimulation ◽  
Extinction Memory

scholarly journals Hypothermia after chronic mild stress exposure in rats with a history of postnatal maternal separations

2013 ◽  
Vol 31 (2) ◽  
pp. 252-264 ◽  
Author(s):  
Jelena Mrdalj ◽  
Åse Lundegaard Mattson ◽  
Robert Murison ◽  
Finn Konow Jellestad ◽  
Anne Marita Milde ◽  
...  
Keyword(s):  
Chronic Mild Stress ◽  
Mild Stress ◽  
Stress Exposure ◽  
History Of

scholarly journals Agomelatine reverses the decrease in hippocampal cell survival induced by chronic mild stress

2011 ◽  
Vol 218 (1) ◽  
pp. 121-128 ◽  
Author(s):  
Girstautė Dagytė ◽  
Ilaria Crescente ◽  
Folkert Postema ◽  
Laure Seguin ◽  
Cecilia Gabriel ◽  
...  
Keyword(s):  
Cell Survival ◽  
Chronic Mild Stress ◽  
Mild Stress ◽  
Hippocampal Cell

P.2.d.023 Agomelatine reverses the decrease in hippocampal cell survival induced by chronic mild stress

2011 ◽  
Vol 21 ◽  
pp. S414-S415
Author(s):  
E. Mocaër ◽  
G. Dagyté ◽  
I. Crescente ◽  
F. Postema ◽  
L. Seguin ◽  
...  
Keyword(s):  
Cell Survival ◽  
Chronic Mild Stress ◽  
Mild Stress ◽  
Hippocampal Cell

Modulation of Monoaminergic Systems by Antidepressants in the Frontal Cortex of Rats After Chronic Mild Stress Exposure

2019 ◽  
Vol 56 (11) ◽  
pp. 7522-7533 ◽  
Author(s):  
David Martín-Hernández ◽  
Marta P. Pereira ◽  
Hiram Tendilla-Beltrán ◽  
José L. M. Madrigal ◽  
Borja García-Bueno ◽  
...  
Keyword(s):  
Frontal Cortex ◽  
Chronic Mild Stress ◽  
Mild Stress ◽  
Stress Exposure

scholarly journals Effect of lurasidone treatment on chronic mild stress-induced behavioural deficits in male rats: The potential role for glucocorticoid receptor signalling

2020 ◽  
Vol 34 (4) ◽  
pp. 420-428 ◽  
Author(s):  
Francesca Calabrese ◽  
Paola Brivio ◽  
Giulia Sbrini ◽  
Piotr Gruca ◽  
Magdalena Lason ◽  
...  
Keyword(s):  
Glucocorticoid Receptors ◽  
Nuclear Translocation ◽  
Dorsal Hippocampus ◽  
Chronic Mild Stress ◽  
Male Rats ◽  
Mild Stress ◽  
Stress Exposure ◽  
Object Recognition Test ◽  
Protein Levels ◽  
Male Wistar Rats

Background: Stress represents one of the main precipitating factors for psychiatric diseases, characterised by an altered function of glucocorticoid receptors (GR), known to play a role in mood and cognitive function. We investigated the ability of the antipsychotic lurasidone to modulate the involvement of genomic and non-genomic GR signalling in the behavioural alterations due to chronic stress exposure Methods: Male Wistar rats were exposed to seven weeks of chronic mild stress (CMS) and treated with lurasidone (3 mg/kg/day) starting from the second week of stress for more five weeks. Gene expression and protein analyses were conducted in dorsal hippocampus. Results: Seven weeks of CMS induced anhedonia and cognitive impairment, which were normalised by lurasidone. At molecular level, CMS rats showed an increase of GR protein levels by 60% ( p<0.001 vs. CTRL/VEH) in the membrane compartment, which was paralleled by an up-regulation of phosphoSINAPSYN Ia/b by 88% ( p<0.01 vs. CTRL/VEH) and of the mitochondrial marker Cox3 by 21% ( p<0.05 vs. CTRL/VEH). Moreover, while exposure to the novel object recognition test increased the nuclear translocation of GRs by 96% ( p<0.01 vs. CTRL/VEH/Naïve) and their transcriptional activity in non-stressed rats, such mechanisms were impaired in CMS rats. Interestingly, the genomic and non-genomic alterations of GR, induced by CMS, were normalised by lurasidone. Conclusion: Our results further support the role of glucocorticoid signalling in the dysfunction associated with stress exposure. We provide novel insights on the mechanism of lurasidone, suggesting its effectiveness on different domains associated with psychiatric disorders.

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