Low‐intensity physical training recovers object recognition memory impairment in rats after early‐life induced Status epilepticus

2013 ◽  
Vol 31 (3) ◽  
pp. 196-201 ◽  
Author(s):  
Sandro Daniel Córdova ◽  
Cássio Morais Loss ◽  
Diogo Losch Oliveira
2012 ◽  
Vol 1466 ◽  
pp. 82-90 ◽  
Author(s):  
Vânia K.M. Moojen ◽  
Marcela Damiani-Neves ◽  
Daniela V. Bavaresco ◽  
Bruna B. Pescador ◽  
Clarissa M. Comim ◽  
...  

Author(s):  
Wellington Almeida ◽  
Heloísa Deola Confortim ◽  
Bruna Ferrary Deniz ◽  
Patrícia Maidana Miguel ◽  
Milene Cardoso Vieira ◽  
...  

2016 ◽  
Vol 311 ◽  
pp. 384-391 ◽  
Author(s):  
Dong Hyun Kim ◽  
Seong-Min Choi ◽  
Jihoon Jho ◽  
Man-Seok Park ◽  
Jisu Kang ◽  
...  

2021 ◽  
Vol 15 ◽  
Author(s):  
Joanne E. Fil ◽  
Sangyun Joung ◽  
Courtney A. Hayes ◽  
Ryan N. Dilger

IntroductionOver the last 40 years, the domestic pig has emerged as a prominent preclinical model as this species shares similarities with humans with regard to immunity, gastrointestinal physiology, and neurodevelopment. Artificial rearing of pigs provides a number of advantages over conventional rearing (i.e., true maternal care), including careful control of nutrient intake and environment conditions. Yet there remains a gap in knowledge when comparing brain development between sow-reared and artificially reared domestic pigs. Thus, our research sought to model brain development and assess recognition memory in a longitudinal manner by directly comparing rearing environments.MethodsForty-four intact (i.e., not castrated) male pigs were artificially reared or sow-reared from postnatal day 2 until postnatal week 4. After postnatal week 4, all pigs were housed in a group setting within the same environment until postnatal week 24. Magnetic resonance imaging was conducted on pigs at 8 longitudinal time-points to model developmental trajectories of brain macrostructural and microstructural outcomes. Additionally, pigs behavior were tested using the novel object recognition task at postnatal weeks 4 and 8.ResultsThroughout the 24-week study, no differences between rearing groups were noted in weekly body weights, average growth and feed intake patterns, or feed efficiency. Whole brain, gray matter, white matter, and cerebrospinal fluid growth patterns also did not differ between pigs assigned to different early-life rearing environments. Moreover, minimal differences in regional absolute volumes and fractional anisotropy developmental trajectories were identified, though artificially reared pigs exhibited higher initial rates of myelination in multiple brain regions compared with sow-reared pigs. Furthermore, behavioral assessment at both PNW 4 and 8 suggested little influence of rearing environment on recognition memory, however, an age-dependent increase in object recognition memory was observed in the sow-reared group.ConclusionOur findings suggest that early-life rearing environment influences the rate of development in some brain regions but has little influence on overall brain growth and object recognition memory and exploratory behaviors in the domestic pig. Artificial rearing may promote maturation in certain brain areas but does not appear to elicit long-term effects in outcomes including brain structure or object recognition memory.


2021 ◽  
Vol 187 ◽  
pp. 108493
Author(s):  
Gerardo Ramirez-Mejia ◽  
Elvi Gil-Lievana ◽  
Oscar Urrego-Morales ◽  
Ernesto Soto-Reyes ◽  
Federico Bermúdez-Rattoni

2010 ◽  
Vol 207 (1) ◽  
pp. 44-50 ◽  
Author(s):  
Patricia Jurado-Berbel ◽  
David Costa-Miserachs ◽  
Meritxell Torras-Garcia ◽  
Margalida Coll-Andreu ◽  
Isabel Portell-Cortés

2012 ◽  
Vol 88 (4) ◽  
pp. 385-391 ◽  
Author(s):  
Luciana Estefani Drumond ◽  
Flávio Afonso Gonçalves Mourão ◽  
Hércules Ribeiro Leite ◽  
Renata Viana Abreu ◽  
Helton José Reis ◽  
...  

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