Using molecular signals controlling embryonic development to direct the differentiation of corticospinal motor neurons

2012 ◽  
Vol 30 (8) ◽  
pp. 658-658
Keyword(s):  
Embryonic Development ◽  
Motor Neurons ◽  
Corticospinal Motor Neurons ◽  
Molecular Signals

scholarly journals Poor Corticospinal Motor Neuron Health Is Associated with Increased Symptom Severity in the Acute Phase Following Repetitive Mild TBI and Predicts Early ALS Onset in Genetically Predisposed Rodents

2021 ◽  
Vol 11 (2) ◽  
pp. 160
Author(s):  
Mor R. Alkaslasi ◽  
Noell E. Cho ◽  
Navpreet K. Dhillon ◽  
Oksana Shelest ◽  
Patricia S. Haro-Lopez ◽  
...  
Keyword(s):  
Risk Factor ◽  
Motor Neuron ◽  
Motor Neurons ◽  
Disease Onset ◽  
Poor Health ◽  
Disease Symptoms ◽  
Established Risk Factor ◽  
Early Injury ◽  
Corticospinal Motor Neurons ◽  
Lateral Sclerosis

Traumatic brain injury (TBI) is a well-established risk factor for several neurodegenerative disorders including Alzheimer’s disease and Parkinson’s disease, however, a link between TBI and amyotrophic lateral sclerosis (ALS) has not been clearly elucidated. Using the SOD1G93A rat model known to recapitulate the human ALS condition, we found that exposure to mild, repetitive TBI lead ALS rats to experience earlier disease onset and shortened survival relative to their sham counterparts. Importantly, increased severity of early injury symptoms prior to the onset of ALS disease symptoms was linked to poor health of corticospinal motor neurons and predicted worsened outcome later in life. Whereas ALS rats with only mild behavioral injury deficits exhibited no observable changes in corticospinal motor neuron health and did not present with early onset or shortened survival, those with more severe injury-related deficits exhibited alterations in corticospinal motor neuron health and presented with significantly earlier onset and shortened lifespan. While these studies do not imply that TBI causes ALS, we provide experimental evidence that head injury is a risk factor for earlier disease onset in a genetically predisposed ALS population and is associated with poor health of corticospinal motor neurons.

scholarly journals Corticospinal Motor Neurons Are Susceptible to Increased ER Stress and Display Profound Degeneration in the Absence of UCHL1 Function

2015 ◽  
Vol 25 (11) ◽  
pp. 4259-4272 ◽  
Author(s):  
Javier H. Jara ◽  
Barış Genç ◽  
Gregory A. Cox ◽  
Martha C. Bohn ◽  
Raymond P. Roos ◽  
...  
Keyword(s):  
Er Stress ◽  
Motor Neurons ◽  
Corticospinal Motor Neurons

IGF-I specifically enhances axon outgrowth of corticospinal motor neurons

2006 ◽  
Vol 9 (11) ◽  
pp. 1371-1381 ◽  
Author(s):  
P Hande Özdinler ◽  
Jeffrey D Macklis
Keyword(s):  
Motor Neurons ◽  
Axon Outgrowth ◽  
Igf I ◽  
Corticospinal Motor Neurons

scholarly journals Corticospinal Motor Neurons and Related Subcerebral Projection Neurons Undergo Early and Specific Neurodegeneration in hSOD1G93A Transgenic ALS Mice

2011 ◽  
Vol 31 (11) ◽  
pp. 4166-4177 ◽  
Author(s):  
P. H. Ozdinler ◽  
S. Benn ◽  
T. H. Yamamoto ◽  
M. Guzel ◽  
R. H. Brown ◽  
...  
Keyword(s):  
Motor Neurons ◽  
Projection Neurons ◽  
Corticospinal Motor Neurons
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