scholarly journals The clinically available NMDA receptor antagonist, memantine, exhibits relative safety in the developing rat brain

2011 ◽  
Vol 29 (7) ◽  
pp. 767-773 ◽  
Author(s):  
Simon M. Manning ◽  
Griffin Boll ◽  
Erin Fitzgerald ◽  
Debra B. Selip ◽  
Joseph J. Volpe ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Receptor Antagonist ◽  
Rat Brain ◽  
Nmda Receptor Antagonist ◽  
Relative Safety ◽  
Developing Rat

scholarly journals Mitochondrial superoxide production and MnSOD activity following exposure to an agonist and antagonists of ionotropic receptors in rat brain

2005 ◽  
Vol 57 (1) ◽  
pp. 1-10
Author(s):  
Lidija Radenovic ◽  
Vesna Selakovic
Keyword(s):  
Nmda Receptor ◽  
Receptor Antagonist ◽  
Rat Brain ◽  
Nmda Receptor Antagonist ◽  
Superoxide Production ◽  
Kainate Receptors ◽  
Glutamate Antagonists ◽  
Time Dynamics ◽  
Mitochondrial Superoxide ◽  
Intrahippocampal Injection

The involvement of NMDA and AMPA/kainate receptors in the induction of superoxide production in the rat brain was examined after intrahippocampal injection of kainate, a non-NMDA receptor agonist; kainate plus CNQX, a selective AMPA/kainate receptor antagonist; or kainate plus APV, a selective NMDA receptor antagonist. The measurements took place at different times in the ipsi- and contralateral hippocampus, forebrain cortex, striatum, and cerebellum homogenates. The used glutamate antagonists both ensured sufficient neuroprotection in the sense of lowering superoxide production and raising MnSOD levels, but in the mechanisms and time dynamics of their effects were different. Our findings suggest that NMDA and AMPA/kainate receptors are differentially involved in superoxide production. <br><br><font color="red"><b> This article has been retracted. Link to the retraction <u><a href="http://dx.doi.org/10.2298/ABS150318026E">10.2298/ABS150318026E</a><u></b></font>

Effect of eliprodil, an NMDA receptor antagonist acting at the polyamine modulatory site, on local cerebral glucose use in the rat brain

1994 ◽  
Vol 664 (1-2) ◽  
pp. 41-48 ◽  
Author(s):  
A. Cudennec ◽  
D. Duverger ◽  
J. Benavides ◽  
B. Scatton ◽  
J.P. Nowicki
Keyword(s):  
Nmda Receptor ◽  
Receptor Antagonist ◽  
Rat Brain ◽  
Nmda Receptor Antagonist

Characterisation of the binding of [3H]FR115427, a novel non-competitive NMDA receptor antagonist, to rat brain membranes

1993 ◽  
Vol 247 (3) ◽  
pp. 319-324 ◽  
Author(s):  
Helen J. Sherriffs ◽  
Kiyoharu Shirakawa ◽  
John S. Kelly ◽  
Henry J. Olverman ◽  
Atsushi Kuno ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Receptor Antagonist ◽  
Rat Brain ◽  
Nmda Receptor Antagonist ◽  
Brain Membranes ◽  
Rat Brain Membranes
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