scholarly journals Hypoxia–ischemia causes persistent movement deficits in a perinatal rabbit model of cerebral palsy: assessed by a new swim test

2009 ◽  
Vol 27 (6) ◽  
pp. 549-557 ◽  
Author(s):  
Matthew Derrick ◽  
Alexander Drobyshevsky ◽  
Xinhai Ji ◽  
Lina Chen ◽  
Yirong Yang ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Rabbit Model ◽  
Swim Test ◽  
Hypoxia Ischemia

scholarly journals Magnitude of [11C]PK11195 Binding Is Related to Severity of Motor Deficits in a Rabbit Model of Cerebral Palsy Induced by Intrauterine Endotoxin Exposure

2011 ◽  
Vol 33 (3-4) ◽  
pp. 231-240 ◽  
Author(s):  
Sujatha Kannan ◽  
Fadoua Saadani-Makki ◽  
Bindu Balakrishnan ◽  
Pulak Chakraborty ◽  
James Janisse ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Rabbit Model ◽  
Motor Deficits ◽  
Endotoxin Exposure

scholarly journals Maternal Inflammation Results in Altered Tryptophan Metabolism in Rabbit Placenta and Fetal Brain

2017 ◽  
Vol 39 (5) ◽  
pp. 399-412 ◽  
Author(s):  
Monica Williams ◽  
Zhi Zhang ◽  
Elizabeth Nance ◽  
Julia L. Drewes ◽  
Wojciech G. Lesniak ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Microglial Activation ◽  
Rabbit Model ◽  
Fetal Brain ◽  
Kynurenine Pathway ◽  
Tryptophan Metabolism ◽  
Maternal Inflammation ◽  
Newborn Brain ◽  
Tryptophan Pathway ◽  
Tryptophan Metabolites

Maternal inflammation has been linked to neurodevelopmental and neuropsychiatric disorders such as cerebral palsy, schizophrenia, and autism. We had previously shown that intrauterine inflammation resulted in a decrease in serotonin, one of the tryptophan metabolites, and a decrease in serotonin fibers in the sensory cortex of newborns in a rabbit model of cerebral palsy. In this study, we hypothesized that maternal inflammation results in alterations in tryptophan pathway enzymes and metabolites in the placenta and fetal brain. We found that intrauterine endotoxin administration at gestational day 28 (G28) resulted in a significant upregulation of indoleamine 2,3-dioxygenase (IDO) in both the placenta and fetal brain at G29 (24 h after treatment). This endotoxin-mediated IDO induction was also associated with intense microglial activation, an increase in interferon gamma expression, and increases in kynurenine and the kynurenine pathway metabolites kynurenine acid and quinolinic acid, as well as a significant decrease in 5-hydroxyindole acetic acid (a precursor of serotonin) levels in the periventricular region of the fetal brain. These results indicate that maternal inflammation shunts tryptophan metabolism away from the serotonin to the kynurenine pathway, which may lead to excitotoxic injury along with impaired development of serotonin-mediated thalamocortical fibers in the newborn brain. These findings provide new targets for prevention and treatment of maternal inflammation-induced fetal and neonatal brain injury leading to neurodevelopmental disorders such as cerebral palsy and autism.

Human Umbilical Cord Mesenchymal Stem Cells Efficiently Improve Neurobehavioral Status and Alleviate Brain Injury in Hypoxia/Ischemia-Induced Cerebral Palsy Rat Model Via Down-Regulating the Nogoa/Ngr/Rho Pathway

2021 ◽  
Author(s):  
Yaoling Luo ◽  
Zhengyi He ◽  
Minhong Zhang ◽  
Zhengwei Zou ◽  
Lincai Li ◽  
...  
Keyword(s):  
Stem Cells ◽  
Nervous System ◽  
Mesenchymal Stem Cells ◽  
Cerebral Palsy ◽  
Brain Injury ◽  
Umbilical Cord ◽  
Rat Model ◽  
Human Umbilical Cord ◽  
Hypoxia Ischemia ◽  
Brain Tissues

Abstract Background: Cerebral palsy (CP) is a brain injury disease, which is a global public health issue with an estimated prevalence of 2‰—4‰ and imposes a substantial health burden on many countries. At present, there is no ideal treatment available and most of them will still suffer adverse outcomes. Human umbilical cord mesenchymal stem cells(HUCMSCs) application in many fields of medicine, which can promote nervous system regeneration and inhibit neuroinflammation. The regeneration of central nervous system(CNS) is related to the nervous regeneration inhibitors. NogoA/NgR/Rho pathway is very important to the nerve growth, CP injury is inevitably accompanied by the regeneration and repair of neurons and axons. so we hypothesized that NogoA/NgR/Rho pathway is involved in when using the HUCMSCs to treatment cerebral palsy.Purpose: In this study, we might clarify the NogoA/NgR/Rho pathway functional role in mediating HUCMSCs to improve neurobehavioral status and alleviate brain injury in hypoxia/ischemia-induced CP rat model.Methods: The CP rat model was established by ligating the left common carotid artery and anoxia for 2.5 h, and HUCMSCs were intravenous injected to the modeled rats. The neurobehavioral situation and brain pathological injury in CP rats were determined via a series of assays. The mRNA and protein expression of NogoA、NgR、RhoA、Rac-1、Cdc42 in brain tissue of rats in each group was detected by RT-qPCR and western blot analysis. Results: The CP rats exhibited obvious motor function abnormalities, pathological damage and a lot of brain nerve cell apoptosis. Compared with CP+PBS group and CP group rats, HUCMSCs transplantation can significantly improve the neurobehavioral situation, attenuated brain pathological injury, inhibit apoptosis of brain nerve cells and the activation of astrocytes in CP rats. The expression of NogoA、NgR、RhoA relative mRNA and protein in brain tissues of rats in the CP+PBS group and CP group rats were significantly lower than those of in the sham+PBS and CP+HUCMSCs group. The expression of Rac-1、Cdc42 relative mRNA and protein in brain tissues of rats in the sham and CP+HUCMSCs group was significantly higher than those of in CP+PBS group and CP group rats. Conclusion: This study confirmed that HUCMSCs can efficiently improve neurobehavioral status and alleviate brain injury in hypoxia/ischemia-induced cerebral palsy rat model via down-regulating the NogoA/NgR/Rho pathway.

scholarly journals Rodent Hypoxia–Ischemia Models for Cerebral Palsy Research: A Systematic Review

2016 ◽  
Vol 7 ◽  
Author(s):  
Prakasham Rumajogee ◽  
Tatiana Bregman ◽  
Steven P. Miller ◽  
Jerome Y. Yager ◽  
Michael G. Fehlings
Keyword(s):  
Systematic Review ◽  
Cerebral Palsy ◽  
Hypoxia Ischemia

scholarly journals Elevated spinal monoamine neurotransmitters after antenatal hypoxia-ischemia in rabbit cerebral palsy model

2015 ◽  
Vol 132 (4) ◽  
pp. 394-402 ◽  
Author(s):  
Alexander Drobyshevsky ◽  
Silvia Honda Takada ◽  
Kehuan Luo ◽  
Matthew Derrick ◽  
Lei Yu ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Monoamine Neurotransmitters ◽  
Antenatal Hypoxia ◽  
Hypoxia Ischemia

scholarly journals Altered Motoneuron Properties Contribute to Motor Deficits in a Rabbit Hypoxia-Ischemia Model of Cerebral Palsy

2020 ◽  
Vol 14 ◽  
Author(s):  
Preston R. Steele ◽  
Clarissa Fantin Cavarsan ◽  
Lisa Dowaliby ◽  
Megan Westefeld ◽  
N. Katenka ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Motor Deficits ◽  
Hypoxia Ischemia

scholarly journals Intrauterine administration of endotoxin leads to motor deficits in a rabbit model: a link between prenatal infection and cerebral palsy

2008 ◽  
Vol 199 (6) ◽  
pp. 651.e1-651.e7 ◽  
Author(s):  
Fadoua Saadani-Makki ◽  
Sujatha Kannan ◽  
Xin Lu ◽  
James Janisse ◽  
Elizabeth Dawe ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Rabbit Model ◽  
Motor Deficits ◽  
Prenatal Infection
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