[P2.47]: Dissection of specific genetic signals from a background of tissue repair and inflammatory response noise during optic nerve regeneration in Danio rerio

2008 ◽  
Vol 26 (8) ◽  
pp. 882-882
Author(s):  
K.E. Saul ◽  
J.R. Koke ◽  
D.M. Garcia
Keyword(s):  
Optic Nerve ◽  
Inflammatory Response ◽  
Nerve Regeneration ◽  
Danio Rerio ◽  
Tissue Repair ◽  
Optic Nerve Regeneration

scholarly journals Lipidomics dataset of Danio rerio optic nerve regeneration model

Data in Brief ◽  
2021 ◽  
pp. 107260
Author(s):  
Jennifer Arcuri ◽  
Matthew B. Veldman ◽  
Sanjoy K. Bhattacharya
Keyword(s):  
Optic Nerve ◽  
Nerve Regeneration ◽  
Danio Rerio ◽  
Optic Nerve Regeneration

scholarly journals Prior Exposure to Immunosuppressors Sensitizes Retinal Microglia and Accelerates Optic Nerve Regeneration in Zebrafish

2019 ◽  
Vol 2019 ◽  
pp. 1-16 ◽  
Author(s):  
Ilse Bollaerts ◽  
Jessie Van houcke ◽  
An Beckers ◽  
Kim Lemmens ◽  
Sophie Vanhunsel ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Inflammatory Response ◽  
Nerve Regeneration ◽  
Nerve Injury ◽  
Molecular Mechanisms ◽  
Strong Positive Correlation ◽  
Cns Injury ◽  
Adult Zebrafish ◽  
Optic Nerve Regeneration ◽  
Retinal Microglia

As adult mammals lack the capacity to replace or repair damaged neurons, degeneration and trauma (and subsequent dysfunction) of the central nervous system (CNS) seriously constrains the patient’s life quality. Recent work has shown that appropriate modulation of acute neuroinflammation upon CNS injury can trigger a regenerative response; yet, the underlying cellular and molecular mechanisms remain largely elusive. In contrast to mammals, zebrafish retain high regenerative capacities into adulthood and thus form a powerful model to study the contribution of neuroinflammation to successful regeneration. Here, we used pharmacological immunosuppression methods to study the role of microglia/macrophages during optic nerve regeneration in adult zebrafish. We first demonstrated that systemic immunosuppression with dexamethasone (dex) impedes regeneration after optic nerve injury. Secondly, and strikingly, local intravitreal application of dex or clodronate liposomes prior to injury was found to sensitize retinal microglia. Consequently, we observed an exaggerated inflammatory response to subsequent optic nerve damage, along with enhanced tectal reinnervation. In conclusion, we found a strong positive correlation between the acute inflammatory response in the retina and the regenerative capacity of the optic nerve in adult zebrafish subjected to nerve injury.

Müller glia–myeloid cell crosstalk accelerates optic nerve regeneration in the adult zebrafish

Glia ◽  
2021 ◽  
Author(s):  
Annelies Van Dyck ◽  
Ilse Bollaerts ◽  
An Beckers ◽  
Sophie Vanhunsel ◽  
Nynke Glorian ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Nerve Regeneration ◽  
Myeloid Cell ◽  
Muller Glia ◽  
Müller Glia ◽  
Adult Zebrafish ◽  
Optic Nerve Regeneration ◽  
Cell Crosstalk

A vulnerable period of colchicine toxicity during goldfish optic nerve regeneration

1999 ◽  
Vol 842 (1) ◽  
pp. 62-72 ◽  
Author(s):  
Joseph A Dybowski ◽  
Anne M Heacock ◽  
Bernard W Agranoff
Keyword(s):  
Optic Nerve ◽  
Nerve Regeneration ◽  
Optic Nerve Regeneration ◽  
Vulnerable Period

scholarly journals zRICH, a protein induced during optic nerve regeneration in zebrafish, promotes neuritogenesis and interacts with tubulin

2012 ◽  
Vol 1474 ◽  
pp. 29-39 ◽  
Author(s):  
Satya S. Pathi ◽  
Soumia Jose ◽  
Suman Govindaraju ◽  
Juan A. Conde ◽  
Hannah E. Romo ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Nerve Regeneration ◽  
Optic Nerve Regeneration

scholarly journals Successful optic nerve regeneration in the senescent zebrafish despite age-related decline of cell intrinsic and extrinsic response processes

2017 ◽  
Vol 60 ◽  
pp. 1-10 ◽  
Author(s):  
Jessie Van houcke ◽  
Ilse Bollaerts ◽  
Emiel Geeraerts ◽  
Benjamin Davis ◽  
An Beckers ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Nerve Regeneration ◽  
Optic Nerve Regeneration ◽  
Age Related

scholarly journals Translational profiling of retinal ganglion cell optic nerve regeneration in Xenopus laevis

2017 ◽  
Vol 426 (2) ◽  
pp. 360-373 ◽  
Author(s):  
G.B. Whitworth ◽  
B.C. Misaghi ◽  
D.M. Rosenthal ◽  
E.A. Mills ◽  
D.J. Heinen ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Xenopus Laevis ◽  
Ganglion Cell ◽  
Nerve Regeneration ◽  
Retinal Ganglion Cell ◽  
Retinal Ganglion ◽  
Optic Nerve Regeneration

Spreading of hemiretinal projections in the ipsilateral tectum following unilateral enucleation: a study of optic nerve regeneration in Xenopus with one compound eye

Development ◽  
1981 ◽  
Vol 61 (1) ◽  
pp. 259-276
Author(s):  
Charles Straznicky ◽  
David Tay
Keyword(s):  
Optic Nerve ◽  
Nerve Regeneration ◽  
Compound Eye ◽  
Rapid Expansion ◽  
Compound Eyes ◽  
Optic Nerve Regeneration ◽  
Xenopus Embryos ◽  
Retinotectal Projections ◽  
Optic Fibre

Right compound eyes were formed in Xenopus embryos at stages 32–33 by the fusion of two nasal (NN), two ventral (VV) or two temporal (TT) halves. Shortly after metamorphosis the optic nerve from the compound eye was sectioned and the left intact eye removed. The retinotectal projections from the compound eye to the contralateral and ipsilateral tecta were studied by [3H]proline autoradiography and electrophysiological mapping between 6 weeks and 5 months after the postmetamorphic surgery. The results showed that NN and VV eyes projected to the entire extent of both tecta. In contrast, optic fibre projection from TT eyes, although more extensive than the normal temporal hemiretinal projection, failed to cover the caudomedial portion of the tecta. The visuotectal projections in all three combinations corresponded to typical reduplicated maps to be expected from such compound eyes, where each of the hemiretinae projected across the contralateral and ipsilateral tecta in an overlapping fashion. The rapid expansion of the hemiretinal projections of the compound eyes in the ipsilateral tectum following the removal of the resident optic fibre projection suggests that tectal markers may be carried and deployed by the incoming optic fibres themselves.

scholarly journals gRICH68 and gRICH70 Are 2′,3′-Cyclic-nucleotide 3′-Phosphodiesterases Induced during Goldfish Optic Nerve Regeneration

1997 ◽  
Vol 272 (17) ◽  
pp. 11479-11486 ◽  
Author(s):  
Rafael P. Ballestero ◽  
George R. Wilmot ◽  
Bernard W. Agranoff ◽  
Michael D. Uhler
Keyword(s):  
Optic Nerve ◽  
Nerve Regeneration ◽  
Cyclic Nucleotide ◽  
Optic Nerve Regeneration
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