Caffeic acid phenethyl ester (CAPE) attenuates cerebral vasospasm after experimental subarachnoidal haemorrhage by increasing brain nitric oxide levels

2006 ◽  
Vol 24 (1) ◽  
pp. 9-14 ◽  
Author(s):  
M. Arif Aladag ◽  
Yusuf Turkoz ◽  
Cemal Ozcan ◽  
Engin Sahna ◽  
Hakan Parlakpınar ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Caffeic Acid ◽  
Cerebral Vasospasm ◽  
Caffeic Acid Phenethyl Ester ◽  
Subarachnoidal Haemorrhage ◽  
Brain Nitric Oxide

Melatonin Ameliorates Cerebral Vasospasm After Experimental Subarachnoidal Haemorrhage Correcting Imbalance of Nitric Oxide Levels in Rats

2009 ◽  
Vol 34 (11) ◽  
pp. 1935-1944 ◽  
Author(s):  
M. A. Aladag ◽  
Y. Turkoz ◽  
H. Parlakpinar ◽  
H. Ozen ◽  
M. Egri ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cerebral Vasospasm ◽  
Subarachnoidal Haemorrhage

Caffeic acid phenethyl ester inhibits nitric oxide synthase gene expression and enzyme activity

2002 ◽  
Vol 175 (1) ◽  
pp. 53-61 ◽  
Author(s):  
Yun Seon Song ◽  
Eun-Hee Park ◽  
Gang Min Hur ◽  
Young Sue Ryu ◽  
Yong Sup Lee ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nitric Oxide ◽  
Enzyme Activity ◽  
Nitric Oxide Synthase ◽  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester ◽  
Oxide Synthase

Protective role of caffeic acid phenethyl ester and erdosteine on activities of purine-catabolizing enzymes and level of nitric oxide in red blood cells of isoniazid-administered rats*

2008 ◽  
Vol 24 (8) ◽  
pp. 519-524 ◽  
Author(s):  
HR Yilmaz ◽  
E Uz ◽  
O Gökalp ◽  
N Özçelik ◽  
E Çiçek ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Red Blood Cells ◽  
Caffeic Acid ◽  
Blood Cells ◽  
Tap Water ◽  
Treated Group ◽  
Caffeic Acid Phenethyl Ester ◽  
Male Rats ◽  
Control Group

The aim of this experimental study was to investigate the possible role of nitric oxide (NO) and the activities of adenosine deaminase (ADA) and xanthine oxidase (XO) in the pathogenesis of isoniazid (INH)-induced oxidative damage in red blood cells (RBCs), and also to show the effect of caffeic acid phenethyl ester (CAPE) and erdosteine, antioxidants, in decreasing this toxicity. A total of 25 adult male rats were divided into four experimental groups as follows: control group ( n = 7), INH-treated group ( n = 6), INH + CAPE–treated group ( n = 6), and INH + erdosteine–treated group ( n = 6). INH, INH-CAPE, and INH-erdosteine–treated groups were treated orally with INH 50 mg/kg daily and with the tap water for 15 days. Control group was given only tap water. CAPE was intraperitoneally injected for 15 days at a dose of 10 μmol/kg. Erdosteine was treated orally for 15 days at a dose of 10 mg/kg/day. The injection of INH led to a significant increase in the activities of ADA, XO, and NO levels in RBCs of rats. Co-treatment with CAPE caused a significant decrease in the activities of ADA and XO and the levels of NO in RBCs. In addition, co-treatment with erdosteine caused a significant decrease in the activities of ADA and XO and the levels of NO in RBCs. The results of this study showed that ADA, XO, and NO may play an important role in the pathogenesis of INH-induced oxidative stress in RBCs. CAPE and erdosteine may have protective potential in this process and they may become a promising drug in the prevention of this undesired side effect of INH.

The activities of liver adenosine deaminase, xanthine oxidase, catalase, superoxide dismutase enzymes and the levels of malondialdehyde and nitric oxide after cisplatin toxicity in rats: protective effect of caffeic acid phenethyl ester

2005 ◽  
Vol 21 (1-2) ◽  
pp. 67-73 ◽  
Author(s):  
H Ramazan Yilmaz ◽  
Sadik Sogut ◽  
Birsen Ozyurt ◽  
Fikret Ozugurlu ◽  
Semsettin Sahin ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Superoxide Dismutase ◽  
Xanthine Oxidase ◽  
Adenosine Deaminase ◽  
Caffeic Acid ◽  
Liver Tissue ◽  
Caffeic Acid Phenethyl Ester ◽  
Control Group ◽  
Albino Rats ◽  
Significant Change

The aim of this experimental study was to investigate the effects of caffeic acid phenethyl ester (CAPE), an antioxidant agent, on cisplatin-induced hepatotoxicity through adenosine deaminase (AD), xanthine oxidase (XO), catalase (CAT), superoxide dismutase (SOD) activities and malondialdehyde (MDA) and nitric oxide (NO) levels in liver tissue of rats. Wistar albino rats were divided into three groups: control group (n-6), cisplatin group (n-9) and CAPE+cisplatin group (n-8). All the chemicals used were applied intraperitoneally. Spectrophotometric methods were used to determine the activities of the above-mentioned enzymes in the liver tissue. NO level and XO activity were found to be increased in the cisplatin group compared to the control group. NO level was found to be decreased in the cisplatin+CAPE group in comparison with the cisplatin group. There was no significant change in the activity of XO between the cisplatin and cisplatin+CAPE groups. The activity of SOD was lower in the cisplatin group than both the control and cisplatin+CAPE groups. There was no significant change in the activity of CAT between the control and cisplatin groups. CAT activity was increased in the cisplatin+CAPE group compared to the cisplatin group. The AD activity and MDA level remained unchanged in all groups. The results obtained suggested that CAPE significantly attenuated the hepatotoxicity as an indirect target of cisplatin in an animal model of cisplatin-induced nephrotoxicity.

Testicular nitric oxide levels after unilateral testicular torsion/detorsion in rats pretreated with caffeic acid phenethyl ester

2000 ◽  
Vol 28 (6) ◽  
pp. 360-363 ◽  
Author(s):  
Uğur Koltuksuz ◽  
M. Kemal Irmak ◽  
Abdurrahman Karaman ◽  
Efkan Uz ◽  
Ahmet Var ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Caffeic Acid ◽  
Testicular Torsion ◽  
Caffeic Acid Phenethyl Ester
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