scholarly journals Sacubitril/valsartan averts post-myocardial infarction ventricular remodeling and preserves heart function

2019 ◽  
Vol 22 ◽  
pp. 218-219
Author(s):  
Adrija Hajra ◽  
Aditi Ujjawal ◽  
Karan Sud ◽  
Sandipan Chakraborty ◽  
Dhrubajyoti Bandyopadhyay
Keyword(s):  
Myocardial Infarction ◽  
Ventricular Remodeling ◽  
Heart Function ◽  
Post Myocardial Infarction

scholarly journals Aliskiren and valsartan mediate left ventricular remodeling post-myocardial infarction in mice through MMP-9 effects

2014 ◽  
Vol 72 ◽  
pp. 326-335 ◽  
Author(s):  
Trevi A. Ramirez ◽  
Rugmani Padmanabhan Iyer ◽  
Omid Ghasemi ◽  
Elizabeth F. Lopez ◽  
Daniel B. Levin ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Ventricular Remodeling ◽  
Left Ventricular Remodeling ◽  
Left Ventricular ◽  
Post Myocardial Infarction

scholarly journals Effects of Combination of Proliferative Agents and Erythropoietin on Left Ventricular Remodeling Post-Myocardial Infarction

2011 ◽  
Vol 4 (3) ◽  
pp. 168-174 ◽  
Author(s):  
Rosemeire M. Kanashiro-Takeuchi ◽  
Lauro M. Takeuchi ◽  
Konstantinos Hatzistergos ◽  
Henry Quevedo ◽  
Sarah M. Selem ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Ventricular Remodeling ◽  
Left Ventricular Remodeling ◽  
Left Ventricular ◽  
Post Myocardial Infarction

scholarly journals Plasma Circulating Extracellular RNAs in Left Ventricular Remodeling Post-Myocardial Infarction

EBioMedicine ◽  
2018 ◽  
Vol 32 ◽  
pp. 172-181 ◽  
Author(s):  
Kirsty M. Danielson ◽  
Ravi Shah ◽  
Ashish Yeri ◽  
Xiaojun Liu ◽  
Fernando Camacho Garcia ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Ventricular Remodeling ◽  
Left Ventricular Remodeling ◽  
Left Ventricular ◽  
Post Myocardial Infarction

Abstract 17357: Direct Cardiac Reprogramming Using Combinatorial Modified mRNA

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Keerat Kaur ◽  
Asharee Mahmoud ◽  
Hanna Girard ◽  
Ann Anu Kurian ◽  
Magdalena Zak ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Gene Delivery ◽  
High Efficiency ◽  
De Novo ◽  
Heart Function ◽  
Lineage Tracing ◽  
Dominant Negative ◽  
Post Myocardial Infarction ◽  
Transduction Efficiency

Introduction: Despite various clinical modalities, ischemic heart disease remains among the leading causes of mortality and morbidity worldwide. The elemental problem is the immense loss of cardiomyocytes (CMs) post-myocardial infarction (MI). Reprogramming non- cardiomyocytes (non-CMs) into cardiomyocyte (CM)-like cells in vivo is a promising strategy for cardiac regeneration: however, the traditional viral delivery method hampered its application into clinical settings due to low and erratic transduction efficiency. Methods: We used a modified mRNA (modRNA) gene delivery platform to deliver different stoichiometry of cardiac-reprogramming genes (Gata4, Mef2c, Tbx5 and Hand2) together with reprogramming helper genes (Dominant Negative (DN)-TGFβ, DN- Wnt8a and Acid ceramidase (AC)), named 7G, to induce direct cardiac reprogramming post myocardial infarction (MI). Results: Here, we identified 7G modRNA cocktail as an important regulator ofthe cardiac reprogramming. Cardiac transfection with 7G modRNA doubled cardiac reprogramming efficiency (57%) in comparison to Gata4, Mef2C and Tbx5 (GMT) alone (28%) in vitro . By inducing MI in our lineage tracing model, we showed that one-time delivery of the 7G-modRNA cocktail reprogrammed ~25% of the non-CMs in the scar area to CM- like cells. Furthermore, 7G modRNA treated mice showed significantly improved cardiac function, longer survival, reduced scar size and greater capillary density than control mice 28 days post-MI. We attributed the improvement in heart function post modRNA delivery of 7G or 7G with increased Hand2 ratio (7G-GMT Hx2) to significant upregulation of 15 key angiogenic factors without any signs of angioma or edema. Conclusions: 7G or 7G GMT HX2 modRNA cocktails boosts de novo CM-like cells and promotes cardiovascular regeneration post-MI. Thus, we highlight that this gene delivery approach not only has high efficiency but also high margin of safety for translation to clinics.

scholarly journals P2Y12 antagonists and cardiac repair post-myocardial infarction: global and regional heart function analysis and molecular assessments in pigs

2018 ◽  
Vol 114 (14) ◽  
pp. 1860-1870 ◽  
Author(s):  
Gemma Vilahur ◽  
Manuel Gutiérrez ◽  
Laura Casani ◽  
Carmen Lambert ◽  
Guiomar Mendieta ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Function Analysis ◽  
Heart Function ◽  
Cardiac Repair ◽  
Post Myocardial Infarction ◽  
P2y12 Antagonists
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